[Non-Hodgkin's lymphoma and pustular psoriasis: a case report]. / Lymphome malin non hodgkinien et psoriasis pustuleux : à propos d'un cas.

Psoriasis has been hypothesized to be associated with lymphoma. Several studies demonstrated an epidemiological relationship between these two entities. Patients with psoriasis are at increased risk for developing lymphoproliferative malignancies. This risk can be also the consequence of immunosuppressive therapies (methotrexate or cyclosporine). We report a 65-year-old man who presented with diffuse erythematous plaques with pustular or squamous borders. Histopathologic evaluation concluded to a pustular psoriasis. We discover simultaneously a stage 4 bone marrow B lymphoma of low grade of malignancy. This case report highlights the relationships between psoriasis and lymphoma.

[Unilateral erythema nodosum and homolateral cutaneous leishmaniasis]. / Erythème noueux unilatéral associé à une leishmaniose cutanée homolatérale.

OBJECTIVE: The authors wanted to report an uncommon etiology of erythema nodosum. CASE REPORT: A 45-year-old woman presented with numerous encrusted nodular lesions on the left leg and arm. Leishmania was identified after a parasitological examination. Subcutaneous erythematous nodules developed later on the same leg. Erythema nodosum was diagnosed with a biopsy of the nodules. The patient was treated with systemic meglumine 60 mg/kg per day for 13 days. All lesions improved under treatment. DISCUSSION: This was the first reported case of unilateral erythema nodosum with cutaneous leishmaniasis. Clinical and laboratory exams were in the range of normal and led the authors to exclude common causes of erythema nodosum. Subcutaneous nodules occurred before the beginning of treatment with meglumine. Thus, drug allergy (previously reported) was excluded as an etiology of EN.

[Management of severe psoriasis: about 50 cases]. / Modalites therapeutiques dans les formes severes de psoriasis: a propos de 50 cas.

BACKGROUND: With its varied clinical presentation, psoriasis is actually considered as a public health care problem. Severe psoriasis remains difficult to treat. METHODS: Our study was retrospective involving 50 patient with severe psoriasis treated in the dermatology unit of military hospital of Tunis from January 1990 to December 2003. Aim of our study was to evaluate actual different therapeutic attitudes and new treatments in case of severe psoriasis. RESULTS: During the 14 years studied the frequency of severe psoriasis was about 19.5%. Extended psoriasis was noticed on 64% of the patients. Arthropatic psoriasis was found on only 6% of the patients. Erythrodermic psoriasis, pustular psoriasis and palmoplantar psoriatic keratoderma were equally noticed in 10% of the patients. PUVA-therapy was firstly prescribed on 96.6% of the patients with extended psoriasis, bettering was noticed on 71% of all them during the 3 first cures. From the 20 patients that have received acitretin, 65% have noticed improvement. Méthotrexate and Re-PUVA was secondarily used (only for the cases of psoriasic arthritis amd méthotrexate) on respectively 18% and 10% of the patients. All our patients reported worsening on thems quality of life. CONCLUSION: Cyclosporin is more and more used initially in cases of rebellious psoriasis. Actually therapeutic hope leans on biological therapies.