RESUMEN
INTRODUCTION: The effectiveness of bowel cleansing is a key element for high-quality colonoscopy. Recently, a 1â¯L polyethylene glycol plus ascorbate (PEG-ASC) solution has been introduced, but effectiveness and safety of this preparation have not been assessed in IBD patients. This study aims to evaluate effectiveness and safety of 1â¯L PEG-ASC solution in patients with IBD compared to controls. METHODS: We retrospectively analysed prospectively collected data on a cohort of 411 patients performing a colonoscopy after preparation with 1â¯L PEG-ASC, consecutively enrolled in 5 Italian centres. RESULTS: Overall, 185/411 (45%) were patients with IBD and 226/411 (55%) served as controls. A significantly higher cleansing success was achieved in IBD patients (92.9% vs 85.4%, pâ¯=â¯0.02). The multiple regression model showed that presence of IBD (OR=2.514, 95%CI=1.165-5.426; Pâ¯=â¯0.019), lower age (OR=0.981, 95%CI=0.967-0.996; Pâ¯=â¯0.014), split preparation (OR=2.430, 95%CI=1.076-5.492; Pâ¯=â¯0.033), absence of diabetes (OR=2.848, 95%CI=1.228-6.605; Pâ¯=â¯0.015), and of chronic constipation (OR=3.350, 95%CI=1.429-7.852; Pâ¯=â¯0.005), were independently associated with cleansing success. The number of treatment-emergent adverse events (TEAEs) (51â¯vs 62%, pâ¯=â¯0.821), and of patients with TEAEs (22.2% vs 21.2%, pâ¯=â¯0.821), were similar in IBD patients and in controls, respectively. CONCLUSIONS: Results from this study support the effectiveness and safety of 1â¯L PEG-ASC solution in IBD patients, which may improve the definition of endoscopic outcomes both in Crohn's disease and ulcerative colitis.
