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Biophys J ; 104(9): 1867-74, 2013 May 07.
Artículo en Inglés | MEDLINE | ID: mdl-23663829

RESUMEN

This article investigates the dynamics of an important bacterial pathogen, Xylella fastidiosa, within artificial plant xylem. The bacterium is the causative agent of a variety of diseases that strike fruit-bearing plants including Pierce's disease of grapevine. Biofilm colonization within microfluidic chambers was visualized in a laboratory setting, showing robust, regular spatial patterning. We also develop a mathematical model, based on a multiphase approach that is able to capture the spacing of the pattern and points to the role of the exopolymeric substance as the main source of control of the pattern dynamics. We concentrate on estimating the attachment/detachment processes within the chamber because these are two mechanisms that have the potential to be engineered by applying various chemicals to prevent or treat the disease.


Asunto(s)
Biopelículas/crecimiento & desarrollo , Microfluídica , Xylella/fisiología , Modelos Biológicos , Vitis/microbiología , Xilema/microbiología
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