RESUMEN
INTRODUCTION: We aimed to analyze the association of nitrotyrosine (N-TYR) levels and long-term survival in an ongoing coronary heart disease (CHD) prospective cohort, the Acute Coronary Syndrome Registry Strategy (ERICO study). METHODS: N-TYR levels collected during acute and subacute phase from onset of acute coronary syndrome (ACS) symptoms (myocardial infarction and unstable angina) were evaluated in 342 patients. We calculated case-fatality rates (180-days, 1â¯year, 2â¯years and 4â¯years) and survival analyses up to 4â¯years using Kaplan-Meier curves and Cox regression with respective cumulative hazard ratios (95% confidence interval; 95%CI), according to N-TYR tertiles up to 4â¯years of follow-up. Models are presented as crude, age and sex-adjusted and further adjusted for lipids and other confounders. RESULTS: Overall, median level of N-TYR was 208.33â¯nmol/l (range: 3.09 to 1500â¯nmol/l), regardless ACS subtype. During follow-up of 4â¯years, we observed 44 (12.9%) deaths. Overall survival rate was 298 (87.1%) (Survival days: 1353, 95%CI: 1320-1387â¯days). N-TYR levels did not associate with mortality / survival rates up to 4â¯years. CONCLUSIONS: No relationship was found between N-TYR levels and mortality rates after ACS during 4-year follow-up in the ERICO study.
Asunto(s)
Síndrome Coronario Agudo/diagnóstico , Enfermedad Coronaria/diagnóstico , Tirosina/análogos & derivados , Síndrome Coronario Agudo/mortalidad , Anciano , Biomarcadores/sangre , Enfermedad Coronaria/mortalidad , Femenino , Humanos , Estimación de Kaplan-Meier , Masculino , Persona de Mediana Edad , Pronóstico , Estudios Prospectivos , Factores de Riesgo , Tasa de Supervivencia , Factores de Tiempo , Tirosina/sangreRESUMEN
AIM: We aimed to analyze the influence of myeloperoxidase (MPO) activity on mortality in the Acute Coronary Syndrome Registry Strategy (ERICO) study. METHODS: MPO activity levels were evaluated in 342 patients. We performed survival analyses using Kaplan-Meier curves and Cox regression with respective hazard ratios, 95% CI, according to MPO tertiles distribution up to 7 years of follow-up. RESULTS: Higher MPO activity levels were seen in men, smokers, diabetics and those who were taking aspirin. MPO activity levels were neither significant in relation to mortality nor to survival rates up to seven years. CONCLUSION: We found no relationship between elevated levels of MPO activity post-acute coronary syndrome and mortality up to 7-years of follow-up in the ERICO study.