1.
Trends Endocrinol Metab
; 33(10): 665-667, 2022 10.
Artículo
en Inglés
| MEDLINE
| ID: mdl-35953432
RESUMEN
Hexokinase (HK)-1 mitochondrial-binding mechanisms and consequential physiological relevance remain unclear. Recently, De Jesus et al. studied myeloid cells with HK1 carrying mutated mitochondrial-binding domains (MBDs) and provided evidence that HK1 localization controls glucose metabolic fate. Increases in cytosolic HK1 may also contribute to the inflammation associated with diabetes and aging.