1.
Bioorg Med Chem Lett
; 20(3): 1137-40, 2010 Feb 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-20022494
RESUMEN
Inhibition of rho kinase (ROCK) has been recognized as an important target for a number of diseases, including glaucoma. Herein we report SAR development around two hits from a kinase library that led to the discovery of the ROCK inhibitor compound 38. In vitro and in vivo analysis of this compound, including its effects in a monkey model of glaucoma will be discussed.