1.
Org Lett
; 23(12): 4575-4578, 2021 06 18.
Artículo
en Inglés
| MEDLINE
| ID: mdl-34085522
RESUMEN
Synthesis of the octacyclic ring system of citrofulvicin is described in nine steps from readily available starting materials. Blocking undesired intramolecular cyclization of a reactive ß-diketone intermediate by transient incorporation of a dithiolane ring led to the formation of the requisite 1-hydroxy-2,4,6-trioxaadamantane ring system of citrofulvicin.