RESUMEN
Children with HIV-1 infection and poor growth have a significant increase in the risk of death. We studied the effects of protease inhibitors on the height and weight of 27 HIV-1-infected children and found that in our small pilot study, protease inhibitor therapy had a positive effect on the heights of HIV-1-infected children. Accelerated height velocity was sustained for at least 18 to 20 months.
Asunto(s)
Estatura/efectos de los fármacos , Peso Corporal/efectos de los fármacos , Trastornos del Crecimiento/prevención & control , Infecciones por VIH/tratamiento farmacológico , Inhibidores de Proteasas/farmacología , Adolescente , Fármacos Anti-VIH/uso terapéutico , Niño , Preescolar , Quimioterapia Combinada , Femenino , Trastornos del Crecimiento/etiología , Infecciones por VIH/complicaciones , Infecciones por VIH/inmunología , Humanos , Lactante , Masculino , Proyectos Piloto , Inhibidores de Proteasas/uso terapéutico , Estudios Retrospectivos , Carga ViralAsunto(s)
Inhibidores de la Proteasa del VIH/uso terapéutico , Síndrome de Emaciación por VIH/tratamiento farmacológico , Hormona de Crecimiento Humana/uso terapéutico , Adolescente , Estatura , Síndrome de Emaciación por VIH/metabolismo , VIH-1 , Humanos , Masculino , Inhibidores de la Transcriptasa Inversa/uso terapéutico , Resultado del Tratamiento , Aumento de PesoRESUMEN
This article presents current knowledge about common childhood thyroid gland disorders. Included are congenital and acquired hypothyroidism, hyperthyroidism, disorders due to iodine deficiency, tumors and miscellaneous conditions. The significance of early diagnosis by screening and institution of treatment of congenital hypothyroidism is emphasized. Etiology, pathogenesis, clinical signs and symptoms, diagnosis and treatment are discussed.
Asunto(s)
Enfermedades de la Tiroides/diagnóstico , Enfermedades de la Tiroides/terapia , Niño , Preescolar , Femenino , Enfermedad de Graves/diagnóstico , Enfermedad de Graves/terapia , Humanos , Hipotiroidismo/diagnóstico , Hipotiroidismo/terapia , Masculino , Pronóstico , Neoplasias de la Tiroides/diagnóstico , Neoplasias de la Tiroides/terapia , Tiroiditis/diagnóstico , Tiroiditis/terapiaRESUMEN
Neonatal meningitis is associated with significant neurologic sequelae. Previous studies from our laboratory and others demonstrated electroencephalography (EEG) to be a useful tool in predicting long-term neurologic outcome in at-risk neonates. We, therefore, retrospectively studied 29 infants with culture-proved neonatal meningitis who died in the neonatal period or survived to follow-up at a mean of 34.4 months. Seventy-five EEGs were obtained during the acute phase of infection; the degree of EEG background abnormality proved to be an accurate predictor of outcome. Infants who had normal or mildly abnormal backgrounds had normal outcomes, whereas those with markedly abnormal EEGs died or manifested severe neurologic sequelae at follow-up. When the EEG was considered with the presence or absence of seizures and the level of consciousness, an accurate prediction of neurologic outcome was obtained in 27 infants (93%). Although the EEG patterns were generally nonspecific, some abnormalities, such as positive rolandic sharp waves, persistent hemispheric or focal voltage attenuation, suggested more specific pathology (i.e., deep white matter necrosis, large-vessel infarction and abscess, respectively). EEG was also valuable for the recognition of subtle and subclinical seizures. Therefore, we conclude that EEG is a valuable tool for predicting the long-term prognoses of infants with neonatal meningitis.