Airline strategies during the pandemic: What worked?

An examination is conducted of airline strategies during the covid-19 pandemic using data from the United States. Our findings show that airlines pursued diverse strategies in terms of route entry and retention, pricing, and load factors. At the route level, a more detailed examination is conducted of the performance of a middle-seat blocking strategy designed to increase the safety of air travel. We show that this strategy (i.e., not making middle seats available to passengers) likely resulted in revenue losses for carriers, an estimated US $3,300 per flight. This revenue loss provides an indication as to why the middle seat blocking strategy was discontinued by all US airlines despite ongoing safety concerns.

The effects of air transport mobility and global connectivity on viral transmission: Lessons learned from Covid-19 and its variants.

We investigate the impact of air travel mobility and global connectivity on viral transmission by tracing the announced arrival time of COVID-19 and its major variants in countries around the world. We find that air travel intensity to a country, "effective distance" as measured by international air traffic, is generally a significant predictor for the announced viral arrival time. The level of healthcare infrastructure in a country is less important at predicting the initial transmission and detection time of a virus. A policy variable, notably the percentage reduction of total inbound seats in response to a viral outbreak, is largely ineffective at delaying viral transmission and discovery time. These findings suggest that air network connectivity is a major contributor to the speed of viral transmission. However, government attempts to delay viral transmission by reducing air network connectivity after the virus is first discovered are largely ineffective.

The management of breakthrough pain during labour.

There is a long history of attempts to alleviate the pain of childbirth, particularly in Asian and Middle Eastern civilisations. In the UK, it was the administration of chloroform to Queen Victoria by John Snow in 1853 that is widely credited with popularizing the idea that labour pain should and could be treated. Medical analgesia is now well established around the globe with a wealth of research evidence describing methods, efficacy and complications. In this article, we define 'primary breakthrough pain' as the moment when a woman first requests analgesia during labour. The management of this can include simple emotional support, inhaled analgesics, parenteral opioids and epidural analgesia. 'Secondary breakthrough pain' can be defined as the moment when previously used analgesia becomes ineffective. We concentrate our discussion of this phenomenon on the situation when epidural analgesia begins to fail. Only epidural analgesia offers the potential for complete analgesia, so when this effect is lost the recipient can experience significant distress and dissatisfaction. The best strategy to avert this problem is prevention by using the best techniques for epidural catheterisation and the most effective drug combinations. Even then, epidurals can lose their efficacy for a variety of reasons, and management is hampered by the fact that each rescue manoeuvre takes about 30 minutes to be effective. If the rescue protocol is too cautious, analgesia may not be successfully restored before delivery, leading to patient dissatisfaction. We therefore propose an aggressive response to epidural breakthrough pain using appropriate drug supplementation and, if necessary, the placement of a new epidural catheter. Combined spinal epidural techniques offer several advantages in this situation. The goal is to re-establish analgesia within 1 hour. The primary aim of pain management during labour and delivery is to provide the level of comfort determined as acceptable to each individual woman. Some require little or no analgesia, while others demand complete abolition of pain. Whatever the individual's personal point of breakthrough pain is, supporting clinicians should respond logically and rapidly to re-establish analgesia using locally agreed protocols. This approach will maximize patient satisfaction and hopefully increase the pleasure and satisfaction of childbirth.

Sedation and anaesthesia for transvaginal oocyte collection: an evaluation of practice in the UK.

BACKGROUND: The objective of the survey was to evaluate sedation and anaesthetic practice employed for oocyte collection in the different assisted conception units in the UK and whether the guidelines of safe sedation were adhered to. METHODS: A survey was carried out by means of a postal questionnaire sent out to the 100 reproductive medicine units of the UK, and 67 of the units responded. RESULTS: A response rate of 67% was achieved. Seventy-seven percent of responding units were part of hospitals with resuscitation facilities; 23% were free-standing without an in-house resuscitation team. Intravenous sedation was the preferred method of sedation for oocyte collection, being used in 62.4% of units. General anaesthesia was the primary method in 24.6% of units. A total of 47.4% of units used a medical member of the reproductive medicine team for administering sedation; 69% of cases were performed in a facility within the unit. One-hundred percent of respondents had oxygen, suction and tilting trolleys. It was reported that 23% of units were free standing, without cover from a resuscitation team. Sedation was performed by non-anaesthetic doctors in 46% and by nurses in 8.2%. In 69%, collections were performed outside of a general operating theatre environment. Also, 4.8% of units had no resuscitation trolley and 21.4% no defibrillator. CONCLUSION: Though most units complied with the guidelines of safe sedation and anaesthesia, gaps have been observed in the safe provision of sedation services for women undergoing oocyte retrieval in some units.

Testicular tumors in Carney's complex.

PURPOSE: Bilateral sex cord stromal testicular tumors are common in the syndrome of myxoma, spotty pigmentation and endocrine overactivity (Carney's complex). Large cell calcifying Sertoli cell tumor is the particular testicular tumor found in Carney's complex. A clinicopathological review of 26 patients is presented. MATERIALS AND METHODS: We report 2 cases of Carney's complex with testicular tumors. An additional 24 patients with Carney's complex and testicular tumors were identified by MEDLINE search and review of the literature. RESULTS: Bilateral testicular tumors were found in 16 patients (61%) with a familial occurrence in 10 (38%). A testicular mass was the most common presentation. The associated findings of Carney's complex included cardiac myxoma in 16 patients, skin myxoma in 16, skin pigmentation in 15, Cushing's syndrome in 8, acromegaly in 3 and schwannoma in 3. Excisional biopsy, surveillance, bilateral orchiectomy and unilateral orchiectomy were performed in 7, 4, 7 and 8 patients, respectively. CONCLUSIONS: No local tumor recurrence or metastasis has developed in patients with bilateral and/or multifocal testicular tumors. Excisional biopsy or surveillance only are treatment options for bilateral testicular tumors in Carney's complex.