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1.
Phytochem Anal ; 19(6): 487-92, 2008.
Artículo en Inglés | MEDLINE | ID: mdl-18446772

RESUMEN

A HPLC-MS fingerprint method has been developed based on the consistent chromatographic features of the major chemical constituents among 10 batches of Hedyotis diffusa Willd. Chromatographic separation was conducted on a Hypersil-Keystone Hypurity C(18) column using methanol:water:acetic acid as the mobile phase. Major compounds, including oleanolic acid, ursolic acid and ferulic acid, were analysed by HPLC-MS. Their analysis was ascertained by comparison with data derived from the standard compounds. The HPLC-MS fingerprint was successfully applied to analyse and differentiate samples from different geographical origins, or processing methods. H. diffusa was well distinguished from Hedyotis chrysotricha by HPLC-MS. Therefore the establishment of fingerprint of H. diffusa is critical in assessing and controlling its overall quality.


Asunto(s)
Medicamentos Herbarios Chinos/análisis , Hedyotis/química , Cromatografía Líquida de Alta Presión/métodos , Espectrometría de Masas , Reproducibilidad de los Resultados
2.
J Ethnopharmacol ; 110(2): 352-5, 2007 Mar 21.
Artículo en Inglés | MEDLINE | ID: mdl-17052876

RESUMEN

Radix Astragali extract (RAE) is obtained from Astragalus membranaceus. It consists of Astragalus polysaccharide and Astragalus membranaceus saponins. In the study, we observed the subchronic toxicity of RAE in Sprague-Dawley rats and beagle dogs to evaluate the safety dosage range in clinical application. These subjects were daily administered of RAE by intra-peritoneum or vein for three consecutive months. General index were observed such as food-intake, behavior, body weight, hematological parameters, etc. Body weight, the weight of principal organ and hematology index are normal in experimental groups and control groups. The hematological biochemistry examination and histopathology examination of experimental groups are similar to control groups. In conclusion, our studies clearly demonstrated that RAE was safe without any distinct toxicity and side effects, the safety dosage range is 5.7-39.9g/kg for rats and 2.85-19.95g/kg for beagle dogs, which is equal to 70 or 35 times of that of human (0.57g/kg, say, average BW 70kg), respectively.


Asunto(s)
Astragalus propinquus/toxicidad , Conducta Animal/efectos de los fármacos , Medicamentos Herbarios Chinos/toxicidad , Animales , Astragalus propinquus/química , Peso Corporal/efectos de los fármacos , Perros , Relación Dosis-Respuesta a Droga , Medicamentos Herbarios Chinos/administración & dosificación , Ingestión de Alimentos/efectos de los fármacos , Tamaño de los Órganos/efectos de los fármacos , Raíces de Plantas/toxicidad , Plantas Medicinales/toxicidad , Polisacáridos/aislamiento & purificación , Polisacáridos/toxicidad , Ratas , Ratas Sprague-Dawley , Saponinas/aislamiento & purificación , Saponinas/toxicidad , Especificidad de la Especie
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