[Diagnosis and treatment of psychogenic dizziness in patients with arterial hypertension].

OBJECTIVE: To analyze the prevalence, methods of diagnosis and treatment of psychogenic dizziness in patients with arterial hypertension and evaluate the efficacy of treatment with noophen and betahistin. MATERIAL AND METHODS: Fifty-eight patients were studied. Patients of the main group received noophen and patients of the comparison group were treated with betahistin. Treatment efficacy was assessed on days 1 and 60 by the scores on VAS, HARS, MFI-20 scales. RESULTS AND CONCLUSION: The prevalence of psychogenic dizziness in patients with arterial hypertension was 47%. Noophen in dose 500 mg/day significantly (p<0.001) reduced the severity of dizziness, anxiety, asthenia, and headache compared to baseline and to the efficacy of betahistin as well. The drug showed good tolerability.

[A role of treatment of autonomic syndrome in patients with tension-type headache].

UNLABELLED: The study aims to evaluate the effect of correction of psycho-vegetative violations anxiolitikami on the frequency and intensity of headache. MATERIAL AND METHODS: the study included 50 women (average age - 37,4 years) with confirmed diagnosis: frequent episodic headache and chronic headache no factor abuses. Patients of the main group received ibuprofen to 200-400 mg/day for headaches in combination with tizanidine (2-4 mg/day) and anvifen 750 mg a day for 8 weeks. Patients in the comparison group received ibuprofen and tizanidine in the same mode, but did not take anvifen. RESULTS AND CONCLUSION: Evaluated the severity of headaches by visual analogue scale, the level of anxiety on the Hamilton depression rating scale, vegetative disorders on questionnaire ( Wayne), the quality of sleep before treatment and 60 days. In addition, 60 day therapy was conducted subjective assessment of the General state on a scale GGI. The conclusion about expediency of inclusion of, anvifen in the complex treatment of the condition.

Possible role and application of fMRI in the screening of release-active drugs.

Functional magnetic resonance imaging (fMRI) of the brain was applied for preclinical evaluation of the efficiency of Divaza preparation intended for the treatment of cerebrovascular disorders. Psychological testing (Stroop task) in the magnetic field of fMRI was performed before and after 12-week treatment course using a double blind placebo-controlled protocol. It was shown that standard psychological and neuropsychological protocols do not allow fully estimate the results of treatment, whereas fMRI targeted the pool of cerebral structures activated during task solution. In the treatment group (in contrast to placebo), active zones in these structures were found only during task solution. Thus, resolution capability of fMRI significantly extends the range of rational screening by identifying active zones and can radically change the procedure of selection and clinical trials.

[Efficiency of using the anxiolytic adaptol in the combination therapy of arterial hypertension in women].

AIM: To evaluate the effect of the anxiolytic adaptol on blood pressure (BP) level in its concurrent use with a fixed dose angiotensin-converting enzyme (ACE) inhibitor/diuretic combination on quality of life and on the correction of psychoautonomic disorders. SUBJECTS AND METHODS: The trial included women aged 40-60 years with the verified diagnosis of Stage 2B arterial hypertension (AH), risk 2, and a disease history of at least 5 years. A study group received a fixed dose ACE inhibitor/diuretic combination once daily and adaptol 500 mg twice daily for 2 months. A comparison group had only the fixed dose ACE inhibitor/diuretic combination once daily without adaptol. RESULTS: By the end of one-month therapy, a more pronounced statistically significant BP reduction was achieved in the study group receiving the ACE inhibitor/diuretic combination and adaptol than in the comparison group. The quality of life was improved in 6 of the 8 items in the study group and in 3 items in the comparison group. The total scores of psychoautonomic disorders decreased from 48.7 to 25.8 in the study group and from 47.8 to 38 in the comparison one. CONCLUSION: It is expedient to combine antihypertensive therapy and anxiolytics in female hypertensive patients with autonomic dystonic disorders.

[Possibilities of antioxidant therapy for asthenia and cognitive deficit in elderly patients with chronic brain ischemia].

AIM: To evaluate the effect of the antioxidant mexidol on the oxidant-antioxidant potential of low-density lipoprotein (LDL), asthenic and anxious symptoms, and cognitive function of neurodynamic type in elderly patients with chronic brain ischemia (CBI). SUBJECTS AND METHODS: Thirty women (mean age 66.7 years) with grade 1-2 dyscirculatory encephalopathy (DE) were examined. Trends for asthenic, anxious, and cognitive symptoms of neurodynamic type were estimated using the standard tests (MFI-20, Hamilton Anxiety Rating Scale, Schulte Tables, Wechsler test) on days 1, 15, and 60 of mexidol treatment (for 60 days). LDLs were isolated from blood by heparin precipitation. The baseline level of lipid peroxidation products was determined and the concentrations of fat-soluble antioxidants (a-tocopherol, retinol, beta-carotene, and xanthins) were examined in the isolated LDLs on days 1 and 5 of the study. RESULTS: A 60-day mexidol therapy cycle statistically significantly caused a reduction in asthenic and anxious symptoms in elderly patients with CBI and induced positive changes in the symptoms of cognitive neurodynamics. Assessing the specific features of the pharmacodynamics of the antioxidant mexidol used in the elderly patients for 15 days revealed a statistically significant positive effect on the oxidative potential of LDLs as a decreased predisposition to their antioxidative processes in vivo. The drug's effect in elevating the levels of a-tocopherol and beta-carotene was altered insignificantly (without statistically significant changes), which reflects the pharmacodynamic features of the drug in the elderly patients. CONCLUSION: The 60-day cycle of therapy with the antioxidant mexidol has a positive impact on asthenic and neurotic symptoms in the elderly patients with CBI. Mexidol is well tolerated and safe when used long.

[Means for improving polyclinic medical care for workers in railroad transportation]. / Puti sovershenstvovaniia poliklinicheskoi meditsinskoi pomoshchi rabotnikam zheleznodorozhnogo transporta.

The paper is concerned with an organizational, structural and functional model of the diagnostic center (DC) in the train, developed by the authors. The DC in the train is a new form of mobile specialized polyclinical aid to the population living in the area of railway stations. The purpose of the model is to draw nearer high-qualified counselling and diagnostic services and prophylactic aid to railway workers. The DC in the train was tried and introduced into western Siberia railway practice. The results of DC in the train establishment are described as is the efficacy of the automated system of early diagnosis of chronic noninfectious diseases, employed under DC conditions.