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Background SARS-CoV-2 infects cells via angiotensin-converting enzyme 2 (ACE2). ACE2 levels are high in the thyroid gland. Although the thyroid gland can be directly infected in COVID-19 patients, the hypothalamic-pituitary-thyroid axis is also affected. Therefore, changes in thyroid function occur in COVID-19 patients. This study aimed to examine the effect of thyroid function tests on the prognosis of COVID-19. Methodology A total of 146 patients who were diagnosed with COVID-19 and treated in the intensive care unit between August and November 2021 and who had no previous history of thyroid disease were included in the study. Demographic information, laboratory tests, and thyroid hormone levels during hospitalization and discharge patterns were evaluated. The patients were divided into two groups: group I included those who were discharged after recovery, and group II included those who did not respond to treatment and died. Results When the fT3 and fT4 levels of the patients were compared, the hormone levels decreased as the clinical severity of the disease increased. The amount of decrease in hormone levels was mostly seen in group II. In the recovered patient group, the amount of hormone decreased was less. The difference between fT3 and ft4 values between the groups was found to be statistically significant (P = 0.015 and P = 0.004). In addition, the difference between the groups' C-reactive protein (CRP), D-dimer, and ferritin values was statistically significant (P = 0.036, P = 0.022, and P < 0.000, respectively). There was no statistically significant difference between the groups in terms of demographic characteristics (P > 0.05). Conclusions Thyroid hormone changes were found to be an important prognostic parameter affecting disease severity and mortality in COVID-19 patients and can be used to predict mortality.
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OBJECTIVE: The frontal QRS-T angle (fQRS-T) is associated with myocardial ischemia and ventricular arrhythmias. On the other hand, acute pulmonary embolism (APE) is a major risk factor for cardiac adverse events. This research aimed to determine whether the fQRS-T, a marker of ventricular heterogeneity, can be used to predict successful thrombolytic therapy in patients with APE. METHODS: This was a retrospective observational study. Patients diagnosed with APE and hospitalized in the intensive care unit between 2020 and 2022 were included in the research. A total of 136 individuals with APEs were enrolled in this research. The patients were divided into two groups: thrombolytic-treated (n=64) and non-treated (moderate to severe risk, n=72). An ECG was conducted for each patient, and echocardiography was performed. RESULTS: The mean age of the thrombolytic group was 58.2±17.6 years, with 35 females (55.1% of the group) and 29 males (44.9%). The non-thrombolytic group had a mean age of 63.1±16.2, with 41 females (56.5%) and 31 males (43.5%). Respiratory rate, heart rate, and fQRS-T were higher in the thrombolytic group, and oxygen saturation ratio and systolic and diastolic blood pressure were higher in the non-thrombolytic group (p=0.006, p<0.001, p=0.021; p<0.001, p=0.015, p<0.001, respectively). In the thrombolytic therapy group, comparing pre- and post-treatment ECG data revealed a statistically significant change in the fQRS-T value (p=0.019). CONCLUSION: The fQRS-T may provide important clues for the successful treatment of APEs.
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OBJECTIVE: The purpose of this study was to compare the effect of body posture and apnea severity on the tone, stiffness, and elasticity of upper airway muscles in awake patients with obstructive sleep apnea syndrome (OSAS). METHODS: Eighty adult patients with OSAS from the Sleep Laboratory of the Bitlis State Hospital between April and December 2021 were included in the study. The tone, stiffness, and elasticity of the genioglossus and accessory muscles (sternocleidomastoid, masseter) were measured while the patients were awake, sitting upright, and in supine posture. According to polysomnography results and the Apnea-Hypopnea Index, patients were classified as mild, moderate, or severe OSAS. RESULTS: There were 56 male (70%) and 24 female (30%) patients (age 45.0 ± 11.0 years). Tone of genioglossus, masseter, and sternocleidomastoid muscles were higher in supine than in sitting posture (all P < .05). There was no difference in elasticity scores of the bilateral genioglossus muscle in sitting and supine posture (P > .05). The elasticity scores of the sternocleidomastoid and masseter muscles were higher in sitting (all P < .05). An interaction effect of postural change and apnea severity was observed on stiffness scores of the genioglossus muscle (P < .05). CONCLUSION: Results showed that the genioglossus muscle and accessory muscles take on the inspiratory load that develops with postural strain, regardless of the severity of apnea, in awake patients with OSAS. For participants measured in this study, accessory muscles supported respiration by increasing their elasticity.