[Multiple sclerosis and melanoma]. / Rasseyannyi skleroz i melanoma.

Multiple sclerosis (MS) is a chronic autoimmune progressive demyelinating disease of the central nervous system, mainly in young people. The clinical picture of MS has a variety of neurological symptoms, which manifests itself during periods of exacerbation or progression and stabilizes at the moments of remission. The widespread introduction of new drugs with immunosuppressive and immunomodulatory mechanisms of action has led to the development of special risk management plans for monitoring patients during therapy and preventing adverse events and new comorbid conditions. This article presents a review of the literature and a case report on the combination of MS and melanoma in patients. Melanoma can rarely develop in patients treated with DMD, so it is necessary to introduce such a specialist in dermatology and venereology into a multidisciplinary team.

Wound healing activity of aqueous dispersion of fullerene C60 produced by "green technology".

In addition to exhibited antioxidant and anti-inflammatory activity, fullerene C60 is a promising wound healing agent. An important stage in the production of fullerene-based ointments is the stability of the aqueous fullerene dispersion (AFD) with minimum size of colloidal fullerene aggregates and sufficiently high concentration. To achieve these parameters tangential flow filtration of fullerene C60 was used ("green technology"). As estimated by small-angle neutron scattering and dynamic light scattering purified AFDs with narrow-size distribution nanoclusters have a size of 6 nm and are assembled into agglomerates which reach a size of 150 nm. The ability of the AFD to exhibit regenerative activity was studied using the animal wound model. This study shows for the first time that the fullerene-based composition stimulates the healing of wounds of various origins. We assume that the mechanism of the AFD wound-healing activity is associated with the aryl hydrocarbon receptor and macrophages activity.

[The problem of chronic tonsillitis as a priority area of scientific research of the Department of Otorhinolaryngology named after acad. B.S. Preobrazhensky]. / Problema khronicheskogo tonzillita kak prioritetnoe napravlenie nauchnykh issledovanii kafedry otorinolaringologii imeni akad. B.S. Preobrazhenskogo.

The article summarizes data on many years of versatile research on the problem of chronic tonsillitis, which were conducted at the Department of Otorhinolaryngology named after acad. B.S. Preobrazhensky Medical Faculty of the Russian National Research Medical University N.I. Pirogov. The research results are presented in the context of the history of the department and the formation of the problem of chronic tonsillitis.

[Chest pain and chronic heart failure as a manifestation of tertiary syphilis: clinical case].

In cardiological practice, there may be patients with chest pain and heart failure of a specific etiology, including an association with cardiovascular syphilis. This article describes a 49-year patient with chest pain, heart failure, and neurological symptoms associated with ongoing tertiary syphilis. The history included an antisyphilitic treatment 30 years before the current hospitalization. Further evaluation confirmed neuro- and cardiovascular syphilis with severe aortic regurgitation and syphilitic myocarditis. Tertiary syphilis is a rare but relevant challenge for various medical specialists, including cardiologists. This pathology requires increased medical alertness and interdisciplinary interaction for early diagnosis, effective and safe treatment, and improved prognosis.

[Study of certain electrophysical properties of adipose tissue in the postmortem period when working with a direct current source]. / Izuchenie nekotorykh elektrofizicheskikh svoistv zhirovoi tkani v posmertnom periode pri rabote s istochnikom postoyannogo toka.

Some features of changes in the electrophysical properties of adipose tissue of animal origin in the postmortem period when working with direct-current sources are considered. OBJECTIVE: Evaluate experimentally the possibilities of registering changes in the electro-physical properties of biological tissues using a direct current source when working with a specific resistance as well as to identify the possible recorded changes in biological tissues when a reverse electromotive force and polarization phenomena occur. At the first stage the fatty subcutaneous layer of a pig was used as samples of adipose tissue which is closely similar to human adipose tissue in composition. In total, during the period of the experimental study the 340 samples of pork fat from two different animals were prepared and used with a reliably unknown slaughter age. As a constant current source in the experiment it was used a system made on the basis of a standard alkaline battery with a declared nominal voltage of 9 V supplemented with necessary radio components. The changes were recorded daily with a digital multi-meter once a day for 10 days. At the end of the experiment the parameters of the electro-physical properties of biological samples were determined using an available direct current source. It was revealed and recorded a clear dynamics of changes in electrophysical parameters associated with the duration of material storage.

Association between Disturbances in Polyunsaturated Fatty Acid Metabolism and Development of Oxidative Stress during Experimental Diabetes Mellitus.

We studied the effect of streptozotocin-induced diabetes mellitus on the level of glycemia and some other indices of lipid metabolism, including fatty acid metabolism and LPO intensity, during the development of diabetes mellitus in rats. Even at the early terms of diabetes development, hypertriglyceridemia and hypercholesterolemia were accompanied by changes in the blood content of fatty acid (at the expense of ω3 and ω6 fatty acids) that persisted throughout the observation period. Intensification of LPO against the background of suppressed activity of antioxidant enzymes and reduced level of ω3 fatty acids attested to the development of oxidative stress. These data attest to antioxidant property of ω3 fatty acids, which is seen from positive correlations between these fatty acids and activity of antioxidant enzymes.

Two-photon three-dimensional optical storage memory.

We describe the design and construction of ultrahigh capacity three-dimensional, 3D, optical storage devices that operate by two-photon absorption. The molecular systems and their properties that are used as two photon media for writing and one photon for accessing the stored information within the volume of the device are presented in some detail and the nonlinear two-photon absorption mechanism is briefly visited. The optical system and its components, which facilitated writing and reading, are also described and the bit density, bit error rate, store and access speeds, cycle times, and stability of the materials under various experimental conditions are also topics addressed in this review. The first ever storage of terabyte data in a removable storage disk is described in detail.

[Endocrine disturbances in circumscribed scleroderma].

AIM: To evaluate prevalence of endocrine pathology in patients with circumscribed scleroderma (CS), baseline immunopathological alterations in CS patients. MATERIAL AND METHODS: Circulating immune complexes were studied by the Digeon method in a total of 70 CS patients (female 52, 74.3%; male 18, 25.7%; age 16 to 70 years). RESULTS: Circulating immune complexes assay by Digeon detected evident immune imbalance characteristic for metabolic disturbances of the connective tissue and affection of the endocrine system. CONCLUSION: CS patients need a combined examination including endocrinological and immunological tests.

Photolysis of CBr4 and its transient solvent stabilized (CBr3+//Br-)solv ion pair.

In this paper we describe the mechanism of the photodissociation of CBr4 in various solvents. We have monitored and identified the intermediate species and determined the growth and decay rates of the excited states and metastable species formed during the photodissociation process by means of ultrafast time-resolved spectroscopy. On the basis of the experimental data presented in this paper, the observed transient spectra and species have been assigned to the stabilized solvated ion pair (CBr3+//Br-)solv.

Nonvolatile read-out molecular memory.

A versatile molecule is described that performs as a nondestructible read-out optical-storage molecular memory. This molecular memory is composed of two distinct molecules that are chemically bonded to each other to form a single molecule with unique properties. One component is a photochromic fulgimide, and the other is a strongly fluorescing oxazine dye. This composite molecule was specifically designed and synthesized to display, under specific conditions, both the photochromic functions of the first component and the fluorescence properties of the dye. To store information, the polar, closed form of the photochromic component is illuminated with 530-nm light, which converts it to the open, nonpolar form. The information is accessed by excitation at the 650-nm band of the oxazine dye component, causing the dye to fluoresce. However, the dye emits intense fluorescence under a nonpolar environment, which is attained only when the fulgimide component is in its open, nonpolar structure. The ultrafast kinetics, spectroscopy, and mechanism of the photoreaction of this molecule and its photoinduced intermediates have been measured, and fluorescence quantum yields and cross sections were determined.

Structures of bromoalkanes' photodissociation in solution by means of ultrafast extended x-ray absorption fine-structure spectroscopy.

The structures of initial and final products of bromoalkanes' photodisociation reaction in cyclohexane solution have been measured with a bond length accuracy of 0.02 A by means of ultrafast time-resolved extended x-ray absorption fine structure spectroscopy. The photoredaction mechanism is also discussed.

Experimental characterization of a two-photon memory.

We demonstrate the recording of 100 planes of digital images in a page-oriented two-photon memory and characterize the images in terms of signal-to-noise ratio and bit error rate. Possible error sources in the recording are discussed, and methods for compensating for some of these effects are presented. Looking at the distributions of the normalized bit intensities, we are able to estimate the minimum achievable bit error rate for this system.

Two-photon-induced photochromic reactions in spirobenzopyran-doped poly(methyl methacrylate) thin-film waveguides.

We present experimental results of photochromic reactions induced by single- and two-photon excitations in a poly(methyl methacrylate) thin film doped with spirobenzopyran. We also demonstrate the operation of a spirobenzopyran-doped poly(methyl methacrylate) planar waveguide, prepared by cast spinning the media onto fused-quartz slides. The following phenomena were shown to take place in this waveguide: single-twophoton coloring, f luorescing, and bleaching. The results indicate that such devices may be suitable for many applications, including optical waveguides, volume optical storage, and optical sensors.