RESUMEN
The role of natural selection in the evolution of human populations from Northeastern Eurasia was studied. Selection for the regions-specific haplogroup C was demonstrated.
Asunto(s)
Indio Americano o Nativo de Alaska , Pueblo Asiatico , ADN Mitocondrial/genética , Selección Genética , Regiones Árticas , Citocromos b/genética , Haplotipos , Humanos , Mutación , NADH Deshidrogenasa/genética , América del Norte , Filogenia , Polimorfismo Genético , SiberiaRESUMEN
The mtDNA variation has been studied in representatives of the Russkoe Ust'e (n = 30), Kolyma (n = 31), and Markovo (n = 26) ethnic subgroups originating from Russian military men, hunters, and fishers who married local Yukaghir women and settled at the Arctic Ocean coast and on the Anadyr' River more than 350 years ago. The mtDNA haplotypes characteristic of indigenous Siberian peoples have been demonstrated to form the basis of the mitochondrial gene pool of long-term Russian resident populations of the region. Only one of 30 identified haplotypes belonging to 11 haplogroups (H2a) is characteristic of European populations. The C and D haplogroups are the most diverse. The analysis has revealed the characteristics of the population structure of the long-term Russian resident populations and allowed them to be interpreted in terms of recent historical and environmental processes.
Asunto(s)
ADN Mitocondrial/genética , Población Blanca/genética , Regiones Árticas , Etnicidad/genética , Femenino , Flujo Génico , Haplotipos , Humanos , Masculino , Mutación , Filogenia , SiberiaRESUMEN
Based on the mtDNA first hypervariable segment sequence variation data, statistical analysis of the diversity in Yukaghirs in comparison with the other indigenous populations of Siberia, was carried out. The level of the Yukaghir mtDNA gene diversity (GD) constituted 0.920, which was only slightly different from the corresponding estimate for the other Siberian populations. Integral estimates of the genetic structure of Siberian populations (k, S, theta(s), and pi) are presented. Phylogenetic analysis, performed using the neighbor-joining method, showed that the Siberian populations clustered irrespectively to their language affiliation. Negative F(s) values found in Yukaghirs pointed to the possible influence of adaptive selection.