RESUMEN
Malnutrition continues to be a major health burden in developing countries. Flow cytometric estimation of the apoptotic marker CD95 in peripheral neutrophils, lymphocytes and monocytes was done for 18 infants with non-oedematous protein energy malnutrition (PEM) and 12 oedematous ones, on hospital admission and after supervised nutritional rehabilitation, and compared with 12 matched controls. CD95 counts in the 3 types of white blood cells were significantly higher in PEM infants and showed improvement after nutritional rehabilitation yet not reaching the control values. Enhanced apoptosis in the leukocytes of peripheral blood of PEM patients may be a marker of increased infection and immune disturbances. This derangement reverses upon proper nutritional rehabilitation.
Asunto(s)
Biomarcadores/análisis , Trastornos de la Nutrición del Lactante/sangre , Leucocitos/química , Desnutrición Proteico-Calórica/sangre , Receptor fas/análisis , Apoptosis/inmunología , Estudios de Casos y Controles , Egipto , Femenino , Citometría de Flujo , Humanos , Lactante , Trastornos de la Nutrición del Lactante/diagnóstico , Trastornos de la Nutrición del Lactante/inmunología , Trastornos de la Nutrición del Lactante/rehabilitación , Recuento de Leucocitos , Leucocitos/inmunología , Linfocitos/química , Masculino , Monocitos/química , Evaluación Nutricional , Estado Nutricional , Valor Predictivo de las Pruebas , Pronóstico , Desnutrición Proteico-Calórica/diagnóstico , Desnutrición Proteico-Calórica/inmunología , Desnutrición Proteico-Calórica/rehabilitación , Estadísticas no Paramétricas , Receptor fas/inmunologíaRESUMEN
Malnutrition continues to be a major health burden in developing countries. Flow cytometric estimation of the apoptotic marker CD95 in peripheral neutrophils, lymphocytes and monocytes was done for 18 infants with non-oedematous protein energy malnutrition [PEM] and 12 oedematous ones, on hospital admission and after supervised nutritional rehabilitation, and compared with 12 matched controls. CD95 counts in the 3 types of white blood cells were significantly higher in PEM infants and showed improvement after nutritional rehabilitation yet not reaching the control values. Enhanced apoptosis in the leukocytes of peripheral blood of PEM patients may be a marker of increased infection and immune disturbances. This derangement reverses upon proper nutritional rehabilitation
