Tamarind genus chemical composition and biological activities.

Tamarindus indica L., the sole species in the genus Tamarind, which is a member of the subfamily Caesalpiniaceae in the family Leguminosae (Fabaceae), is extensively dispersed in many tropical and subtropical regions. This plant's Arabic name, Tamr Al-Hindi, is the basis for its English name, Tamarind. In traditional medicine, this genus has played a major role since the time of the ancient Egyptians. Folkloric medicine has traditionally used Tamarind to treat a variety of conditions, including diabetes mellitus, fever, malaria, ulcers, diarrhoea, dysentery and wounds. The primary bioactive components of this species, which have a variety of biological functions, have been identified as flavonoids, phenolic contents, sterols, triterpenes, fatty acids, sugars and other substances. Genus Tamarind has been shown to have anti-inflammatory, analgesic, anti-pyretic, antibacterial, hypolipidemic, anti-diabetic, hepatoprotective, anti-ulcerogenic and antioxidant properties. This article provides an overview of the identified chemicals from T. indica together with their stated biological activities.

Exploring the anti-obesity bioactive compounds of Thymelaea hirsuta and Ziziphus spina-christi through integration of lipase inhibition screening and molecular docking analysis.

Activity-guided fractionation of the ethanolic extracts of Thymelaea hirsuta and Ziziphus spina-christi furnished eight compounds with pancreatic lipase inhibitory activity. Six compounds were isolated from the chloroform fraction of T. hirsuta. It is worth mentioning that this is the first report for the isolation of 5,7,4'-trihydroxy-8-methoxycarbonyl flavanol (2), daphnodorin G-3''-methyl ether (4) and daphnodorin G (5) from genus Thymelaea. Moreover, daphnoretin (1), neochamaejasmin A (3) and daphnodorin B (6) were also isolated from the chloroform fraction of the same plant. On the other hand, quercetin 3-O-α-l-rhamnopyranosyl-(1 → 2)-[α-l-rhamnopyranosyl-(1 → 6)]-ß-d-galactopyranoside (7) and 3-O-[α-l-fucopyranosyl-(1 → 2)-ß-d-glucopyranosyl-(1 → 3)-α-l-arabinopyranosyl] jujubogenin (christinin A) (8) were isolated from the n-butanol fraction of Z. spina-christi. Structure elucidation of the isolated compounds was carried out by detailed analysis of 1D and 2D spectral data. These compounds showed percentage inhibitions of 72% (1), 52% (2), 61.8% (3), 39% (4), 69.5% (5), 3.5% (6), 68% (7) and 75% (8) at the concentration of 250 µM and XP-G scores of lipase inhibition were 11.40 (1), 8.71 (2), 6.13 (3), 8.23 (4), 6.22 (5), 9.76 (6), 14.66 (7) and 12.00 (8). This is the first report of the isolation of lipase inhibitors from both plants T. hirsuta and Z. spina-christi. In addition to that, this might result in presenting the biscoumarin, daphnoretin, and the dammarane saponin, christinin A, as potent lipase inhibitors.

Phytochemical and pharmacological appraisal of the aerial parts of Lotus corniculatus L. growing in Egypt.

Lotus corniculatus L. (Fabaceae) is widely grown in Egypt. It has a great history of folkloric medicinal uses. All fractions of aerial parts of L. corniculatus L. showed significant antioxidant and immunostimulant activities and could strongly induce lymphoproliferation. However, the light petrol fraction had antifungal activity against C. neoformans with IC50 value (<8 µg/mL) and exhibited strongest in-vitro antiprotozoal activity against protozoan parasites belonging to the genera Trypanosoma with IC50 value (0.98 µg/mL) and Plasmodium (with 100% inhibition using a sample concentration of 15866.7 ng/mL). This is the first study of the immunostimulant and antiprotozoal activities of genus Lotus. By this approach, it was possible to isolate eight compounds (-)-7,2'-dihydroxy-4'-methoxyisoflavan (vestitol) (1), kaempferol (2), kaempferol 3-O-α-L-rhamnoside (afzelin) (3), kaempferol 3, 7-O-α-L-dirhamnoside (kaempferitin) (4), kaempferol-3-O-[ß-D-xylopyranosyl (1″'→2″)-ß-D-galactopyranoside] (5), 3-O-[ß-D-glucuronopyranosyl] soyasapogenol B (6), kaempferol-3-O-[ß-D-xylopyranosyl (1″'→2″)-ß-D-galactopyranoside]-7-O-α-L-rhamnopyranoside (7) and 3-O-[α-L-rhamnopyranosyl (1″'→2″)-ß-D-galactopyranosyl-(1″→2')-ß-D-glucuronopyranosyl] soyasapogenol B (soyasaponin І) (8).