RESUMEN
alpha-Heterocyclic alpha-aminoesters were obtained in good yields by reaction of a glycine cation equivalent and different heterocyclic nucleophiles; diastereoselectivity using a carbohydrate (galactopyranose) as N-protecting group was modest.
Asunto(s)
Aminoácidos/química , Compuestos Heterocíclicos/síntesis química , Ésteres , Estructura MolecularRESUMEN
Interest in non-natural amino acids is growing because of their potential biological activity. We describe in this paper, a synthesis of phosphonic analogues of 4-hydroxy proline and 5-hydroxy pipecolic acid.
Asunto(s)
Hidroxiprolina/análogos & derivados , Hidroxiprolina/síntesis química , Organofosfonatos/síntesis química , Ácidos Pipecólicos/síntesis química , Animales , Ciclización , Hidroxiprolina/química , Estructura Molecular , Organofosfonatos/química , Ácidos Pipecólicos/química , RatasRESUMEN
We report here the synthesis of biheterocyclic alpha-amino acids by 1,3 dipolar cycloaddition of acetylenic compounds on alpha-azido alpha-amino esters.
Asunto(s)
Aminoácidos/química , Aminoácidos/síntesis química , Ésteres/química , Espectroscopía de Resonancia Magnética , Tetrazoles/síntesis química , Tetrazoles/química , Triazoles/síntesis química , Triazoles/químicaRESUMEN
Interest in non-natural alpha-amino acids is growing because of their potential biological activity. We describe, in this paper, a synthesis of beta-tetrazolyl alpha-amino esters by action of 5-aryl tetrazoles, 2, on N-benzyloxycarbonyl di-dehydro methylalaninate, 3.
