Obliterative bronchiolitis: varying presentations and clinicopathological correlation.

In obliterative bronchiolitis, inflammation and fibrosis lead to narrowing or occlusion of bronchiolar lumina. To determine how bronchiolar structural alterations relate to lung physiology, 19 patients with a pathological diagnosis of obliterative bronchiolitis were studied. The bronchiolar inflammatory and fibrotic features were correlated to the clinical presentation, and lung function tests. Eleven patients demonstrated airflow limitation, one had a restrictive pattern and one had a mixed pattern, two had isolated gas trapping, but four had normal spirometry. Mild-to-moderate bronchiolar inflammation was invariably present. It involved 60% of bronchioles subepithelially and 54% in the adventitia. Subepithelial fibrosis was observed in 15 patients and adventitial in 12. Adventitial bronchiolar inflammation correlated with forced expiratory volume in one second and forced vital capacity and inversely correlated with residual volume. Subepithelial fibrosis inversely correlated with subepithelial and adventitial inflammation. High-resolution computed tomography in 10 patients revealed inspiratory (five out of 10) and expiratory air trapping (five out of five), ground glass opacities (seven out of 10), bronchial wall thickening (five out of 10), bronchiectasis (two out of 10) and centrilobular nodules (two out of 10). The present study suggests that inflammation and fibrosis occurs in bronchioles at different time points in the disease process, or that there is no transition between these types of pathology in the same patient. No correlation was observed between the degree of bronchiolar fibrosis and the degree of airflow limitation.

Variability and accuracy of measurements of prostate brachytherapy seed position in vitro using three-dimensional ultrasound: an intra- and inter-observer study.

This paper is a step in investigating whether three-dimensional (3D) ultrasound can be used intraoperatively to replace Computed Tomography (CT) for localization of brachytherapy seeds. In order to quantify the accuracy and variability of seed localization without introducing effects due to tissues, we first report our results with test phantoms. An inter- and intra-observer study was performed to assess the variability of 2 3D ultrasound scan acquisition methods: Tilt 3D scanning and pull-back 3D scanning. Seven observers measured the positions of gold seed markers in an agar phantom twice in each of the three orthogonal image planes. An analysis of variance (ANOVA) was performed to determine the intra- and inter-observer standard errors of measurement (SEM) and the minimum detectable changes in marker position (deltap). Average intra- and inter-observer SEMs for the tilt scan 3D image were 0.36 and 0.40 mm, respectively. Measurements of the pull-back scan 3D image yielded average intra- and inter-observer SEM of 0.46 and 0.49 mm, respectively. A paired difference analysis showed that the lower SEM for the tilt 3D scan image were statistically significant at a significance level of alpha= 0.05. The accuracy of the US measurements was tested by determining marker coordinates from CT images of the phantom in a stereotactic head frame. CT coordinates were matched to the ultrasound (US) coordinates by means of an affine transform. Average matching errors in x, y, and z were 0.02, 0.10, and -0.02 mm, respectively.

Accuracy of prostate volume measurements in vitro using three-dimensional ultrasound.

RATIONALE AND OBJECTIVES: We assessed the ability of a three-dimensional (3D) ultrasound imaging system to measure accurately prostate volume. METHODS: Multiple two-dimensional ultrasound images of cadaver prostates scanned in a water bath were reconstructed into three-dimensional (3D) images. The volumes of the prostates were calculated from these 3D images and compared with the actual volumes. Multiple 3D ultrasound volume readings were evaluated for precision. RESULTS: The slope of the best-fit line correlating 3D ultrasound estimated volume and true volume was 1.006 +/- 0.007. The average error was 0.36 +/- 1.17 cm3; the coefficient of determination (r2), which is the measure of the straight-line relationship, was .9997; and the standard error was 1.15 cm3. CONCLUSION: Three-dimensional ultrasound images accurately reflect true prostate volumes measured in vitro.