[Therapeutic cellular angiogenesis in treatment of peripheral artery diseases].

High incidence of peripheral artery disease and limited possibilities of either open or endovascular methods of treatment, as well as low efficacy of medicamentous treatment of this pathology compel the professionals concerned to search for new methods of treatment aimed at improving the condition of the distal arterial bed, decreasing peripheral resistance and stimulating the development of the capillary network. One of the possible ways to solve this problem is the use of cellular technologies for stimulating angiogenesis. This novel and rather promising method consists in using autologous cell therapy in treatment of peripheral arterial diseases.

[Comparative data on the use of a cryosupernatant and fresh-frozen plasma in the therapy of a protracted infectious-septic syndrome of disseminated intravascular coagulation]. / Sravnitel'nye dannye ob ispol'zovanii kriosupernatanta i svezhezamorozhennoi plazmy v terapii zatiazhnogo infektsionno-septicheskogo sindroma disseminirovannogo vnutrisosudistogo svertyvaniia krovi.

AIM: To compare therapeutic effectiveness of cryosupernatant plasma fraction (CSP) and fresh-frozen plasma (FFP) in long-term infectious-septic DIC syndrome arising in acute abscess and gangrene of the lung. MATERIALS AND METHODS: 106 and 131 patients with infectious-septic DIC syndrome were treated with CSP and FFP, respectively. The results of the treatment were compared clinically and hemotopogically. RESULTS: Clinical response to both treatments was evident from positive changes in XIIa-dependent fibrinolysis, lowering of fibrinogen level and enhanced activity of antithrombin III. CSP treatment brought about a decrease in the number of thromboses, lethal cases, unfavorable outcomes. CONCLUSION: The cryosupernatant can be used instead of fresh-frozen plasma in combined treatment of long-standing infectious-septic DIC syndrome.