ChatGPT prompts for generating multiple-choice questions in medical education and evidence on their validity: a literature review.

ChatGPT's role in creating multiple-choice questions (MCQs) is growing but the validity of these artificial-intelligence-generated questions is unclear. This literature review was conducted to address the urgent need for understanding the application of ChatGPT in generating MCQs for medical education. Following the database search and screening of 1920 studies, we found 23 relevant studies. We extracted the prompts for MCQ generation and assessed the validity evidence of MCQs. The findings showed that prompts varied, including referencing specific exam styles and adopting specific personas, which align with recommended prompt engineering tactics. The validity evidence covered various domains, showing mixed accuracy rates, with some studies indicating comparable quality to human-written questions, and others highlighting differences in difficulty and discrimination levels, alongside a significant reduction in question creation time. Despite its efficiency, we highlight the necessity of careful review and suggest a need for further research to optimize the use of ChatGPT in question generation. Main messages  Ensure high-quality outputs by utilizing well-designed prompts; medical educators should prioritize the use of detailed, clear ChatGPT prompts when generating MCQs. Avoid using ChatGPT-generated MCQs directly in examinations without thorough review to prevent inaccuracies and ensure relevance. Leverage ChatGPT's potential to streamline the test development process, enhancing efficiency without compromising quality.

Assessing the Responses of Large Language Models (ChatGPT-4, Gemini, and Microsoft Copilot) to Frequently Asked Questions in Breast Imaging: A Study on Readability and Accuracy.

Background Large language models (LLMs), such as ChatGPT-4, Gemini, and Microsoft Copilot, have been instrumental in various domains, including healthcare, where they enhance health literacy and aid in patient decision-making. Given the complexities involved in breast imaging procedures, accurate and comprehensible information is vital for patient engagement and compliance. This study aims to evaluate the readability and accuracy of the information provided by three prominent LLMs, ChatGPT-4, Gemini, and Microsoft Copilot, in response to frequently asked questions in breast imaging, assessing their potential to improve patient understanding and facilitate healthcare communication. Methodology We collected the most common questions on breast imaging from clinical practice and posed them to LLMs. We then evaluated the responses in terms of readability and accuracy. Responses from LLMs were analyzed for readability using the Flesch Reading Ease and Flesch-Kincaid Grade Level tests and for accuracy through a radiologist-developed Likert-type scale. Results The study found significant variations among LLMs. Gemini and Microsoft Copilot scored higher on readability scales (p < 0.001), indicating their responses were easier to understand. In contrast, ChatGPT-4 demonstrated greater accuracy in its responses (p < 0.001). Conclusions While LLMs such as ChatGPT-4 show promise in providing accurate responses, readability issues may limit their utility in patient education. Conversely, Gemini and Microsoft Copilot, despite being less accurate, are more accessible to a broader patient audience. Ongoing adjustments and evaluations of these models are essential to ensure they meet the diverse needs of patients, emphasizing the need for continuous improvement and oversight in the deployment of artificial intelligence technologies in healthcare.

Decoding medical jargon: The use of AI language models (ChatGPT-4, BARD, microsoft copilot) in radiology reports.

OBJECTIVE: Evaluate Artificial Intelligence (AI) language models (ChatGPT-4, BARD, Microsoft Copilot) in simplifying radiology reports, assessing readability, understandability, actionability, and urgency classification. METHODS: This study evaluated the effectiveness of these AI models in translating radiology reports into patient-friendly language and providing understandable and actionable suggestions and urgency classifications. Thirty radiology reports were processed using AI tools, and their outputs were assessed for readability (Flesch Reading Ease, Flesch-Kincaid Grade Level), understandability (PEMAT), and the accuracy of urgency classification. ANOVA and Chi-Square tests were performed to compare the models' performances. RESULTS: All three AI models successfully transformed medical jargon into more accessible language, with BARD showing superior readability scores. In terms of understandability, all models achieved scores above 70%, with ChatGPT-4 and BARD leading (p < 0.001, both). However, the AI models varied in accuracy of urgency recommendations, with no significant statistical difference (p = 0.284). CONCLUSION: AI language models have proven effective in simplifying radiology reports, thereby potentially improving patient comprehension and engagement in their health decisions. However, their accuracy in assessing the urgency of medical conditions based on radiology reports suggests a need for further refinement. PRACTICE IMPLICATIONS: Incorporating AI in radiology communication can empower patients, but further development is crucial for comprehensive and actionable patient support.

Exploring celiac trunk parameters in median arcuate ligament syndrome: A CT study.

PURPOSE: To assess anatomical variations in the celiac trunk (Ct) in patients with Median Arcuate Ligament Syndrome (MALS) using computed tomography (CT). The primary objectives were to investigate the celiac trunk angle (CtA), origin level, length (CtL), and their relationships with the superior mesenteric artery (SMA) in MALS patients. Additionally, the study intended to evaluate gender differences in these parameters and explore correlations between variables. METHODS: Retrospectively, reports of abdominal CT scans taken between January 2018, and Sepmtember 2021, in the hospital image archive were screened vey two observers independently for MALS diagnosis. Parameters such as CtA, CtL, Ct-SMA distance, SMA angle (SMAA), and median arcuate ligament thickness (MALT) were measured. Statistical analyses were conducted using SPSS software. RESULTS: Among the 81 patients (25 females, 56 males), significant differences were observed in MALT between genders (p = 0.001). CtA showed a negative correlation with CtL and Ct-SMA (p < 0.001), and a positive correlation was found between CtL and Ct-SMA (p = 0.002). CtL was measured as 25 mm for the all group. Origin levels of Ct and SMA were evaluated in comparison to vertebral levels. Ct-SMA distance was relatively shorter (9.19 mm) compared to the literature. SMAA findings were consistent with normal population values. CONCLUSION: This study provided valuable insights into the anatomical parameters of the Ct ans SMA in MALS patients. Despite some differences compared to normal population parameters, no evidence supported the hypothesis of a superiorly placed Ct contributing to MALS.

Sex Determination Using Frontal Sinus Diameters on Direct Radiography.

BACKGROUND AND AIM: The shape and developmental stages of the frontal sinus (FS) differ in each individual, it can be used to determine sex and identity. This study aimed to assess the morphological structure of the FS diameters in sex determination using posterioanterior (AP) skull radiography. This data can be valuable for identifying and characterizing human features. METHODS: The study included 350 patients (171 females, 179 males) aged between 20 and 55 years who underwent AP skull radiography. FSs were classified as symmetrical, asymmetrical, unilateral, or bilateral aplasic. The right and left FS height and width measurements were made based on the largest diameters. RESULTS: The mean age was 32.8±11.45 years for the whole sample. The mean age of the males was 31.23±11.9 (20-51) years and that of the females was 34.45±10.75 (20-55) years. When classified anatomically, 20 patients had bilateral aplasia (12 males, eight females), 19 patients had right aplasia (10 males, nine females), and 11 patients had left aplasia (seven males, four females). FS was symmetrical in 206 (72.1%) patients while right dominance was observed in 33 (9.43%) patients and left dominance in 61 (17.43%) patients. The FS height and width values on both sides ​​were statistically significantly higher in males than in females (p<0.001 for each parameter). The females were accurately classified at a rate of 71.2% and the males at 68.2%. CONCLUSION: Notably, our research has revealed that frontal sinus diameters are consistently larger in males than in females, and that direct radiography can be employed for gender determination with an accuracy rate of 69.7%. This information underscores the utility of morphometric evaluation of the frontal sinus diameters on direct radiography for gender and identity determination, potentially in conjunction with other parameters. In conclusion, our study has demonstrated the potential of the morphological structure of the frontal sinuses as a valuable tool for identifying and characterizing human individuals.

Relationship between medial meniscus extrusion and damage to medial stabilizers: Should extrusion be considered significant only when more than 3 mm?

BACKGROUND: This study was conducted with patients with anterior and medial extrusion of the medial meniscus (MM-AE, MM-ME) to investigate the relationship of the amount of extrusion with damage to the meniscus, meniscofemoral ligament (MFL), meniscotibial ligament (MTL), presence of effusion, osteoarthritis (OA) grade and other medial stablizers. A cut-off value for significant MM-ME was also suggested. METHODS: All patients aged 18 and above who had measurable MM extrusion on knee MRI were included. Patients with acute injury detected on knee MRI and any disease that could disrupt the anatomy were not included. The relationship between the amount of MM-AE, MM-ME and the investigated comorbidities were evaluated. The patients were divided into two: those with and without positive findings for each comorbidities. The amount of MM-AE, MM-ME were evaluated. ROC analysis was undertaken for significant differences, and cut-off values were determined. RESULTS: There was a correlation between MM-ME and age, weight, and BMI (p < 0.001, p = 0.027, p = 0.025, respectively). The amount of MM-ME was higher in the groups with OA (p = 0.007), MTL damage (p < 0.001), MFL damage (p < 0.001), meniscus damage (p < 0.001), effusion (p < 0.001), and the amount of MM-AE was higher in the groups with OA (p = 0.042), effusion (p = 0.002). The cut-off values of MM-ME were determined to be 2.69 mm (MTL), 2.65 mm (MFL), 2.49 mm (meniscus), and 2.85 mm (OA). CONCLUSION: OA grade, effusion, and meniscus, MTL, and MFL damage were all found to be related to the amount of MM-ME. MM-ME values 2.49-2.85 mm may indicate meniscus, MFL, MTL damage and OA.

The Relationship of Renal Augmented Velocity Index With Ventricular-Arterial Coupling in Comparison to Renal Resistive Index: Analysis by Means of Arterial and Ventricular Elastances in Hypertensive Patients.

OBJECTIVE: It's a well-known scientific statement that the heart and kidney functions are frequently tied together and the impairment of one directly alters the other. However, there exist knowledge gaps about this intricate pathophysiologic link and the exact unifying mechanism is not established. Herein, we aimed to investigate the presence of cardiorenal interaction at subclinical level while the conventional cardiac and renal clinical parameters are not disrupted yet in patients with hypertension. METHODS: We chose a novel renal Doppler ultrasonographic parameter-augmented velocity index (Avi)-and an echocardiographic measure-ventriculoarterial coupling-which is complex to analyze but increasingly used after its acceptance about being a key determinant of cardiovascular efficiency. We recruited 137 patients without a previous history of antihypertensive medication use (47.4% women; median age, 49 years). Renal Avi, renal resistive index (RI), arterial elastance (Ea ), ventricular elastance (Ees ) and Ea /Ees (ventriculoarterial coupling) parameters were all examined. RESULTS: Renal Avi, Ea , and Ea /Ees values were higher in females. Correlation analysis revealed that renal Avi was correlated with many hemodynamic variables including Ea and Ea /Ees . On multiple linear regression analysis, Ea and Ea /Ees remained as significant independent predictors of renal Avi but not of renal RI after adjustments for co-variables (ß = 0.488, P < .001 for Ea ; ß = 0.380, P < .001 for Ea /Ees ). CONCLUSIONS: In comparison to renal RI, we suggest that renal Avi is a more reliable and promising index that can even measure subclinical changes in the cardiorenal circulation which needs to be elucidated.

Rectus Sheath Hematoma as a Complication in Patients With COVID-19: Clinical and Imaging Findings.

Objectives This study aims to investigate the frequency of rectus sheath hematoma (RSH), clinical findings, imaging findings, and prognosis in patients admitted to the hospital due to COVID-19. Methods In this retrospective study, the patient's demographic characteristics, known diseases, laboratory values, RSH-related symptoms, the treatment they received, imaging modality used to diagnose RSH, and side and size of RSH were recorded. In addition, the inpatient ward to which the patients were admitted, length of hospital stay, time from the beginning of anticoagulant use to the diagnosis of RSH, and prognosis were noted. Results A total of 9,876 patients were admitted to the hospital due to COVID-19 and started anticoagulant treatment. Of these patients, 12 (0.12%) were determined to have RSH (female/male ratio: 5). The prothrombin time, activated partial thromboplastin time, international normalized ratio, hemoglobin, and hematocrit values ​​of 11 patients were within the reference ranges. The mean length of hospital stay was 12 (4.25-22.5) days, and the duration of anticoagulant use was 5.5 (4-10.75) days. RSH was diagnosed using USG in 10 patients and CT in two patients. Conclusion There has been an increase in the use of anticoagulants due to COVID-19, and accordingly, RSH is now more frequently diagnosed and has a more fatal course. Female gender, advanced age, severe COVID-19 disease, and elevated d-dimer at the time of presentation can be considered risk factors for the development of RSH. All physicians who treat and follow up on patients with COVID-19 should consider the possibility of RSH in the differential diagnosis of patients with acute abdominal pain and palpable masses. USG should be undertaken as the first-line imaging modality for the diagnosis of patients, but CT may also be necessary to detect RSH in some cases.

Prognostic Value of Diaphragm Diameter, Muscle Volume, and Bone Mineral Density in Critically Ill COVID-19 Patients.

Objective: We aimed to analyze the prognostic value of muscle volume (MV), bone mineral density (BMD), and diaphragm diameter (DD) in COVID-19. Method: The study included 498 patients admitted to the intensive care unit (ICU) with a positive polymerase chain reaction test for COVID-19 from March 11, 2020, through August 31, 2022. The patients' laboratory and demographic data of the patients at the time of ICU admission were recorded. MV, DD, and BMD measurements were performed using computed tomography examinations. Muscle index (MI) was calculated as MV/height2. Quartiles were determined for all 4 measurements. Patients in the lowest quartile were recorded as having low MV, MI, DD, and BMD values. The parameters were evaluated for the whole group and compared according to gender and mortality. The multiple regression analysis was performed for the prediction of mortality. Results: In the mortality group, the male and female patients had significantly statistically lower values in MV (P < .001 and P = .002, respectively), MI (P < .001 and P = .005, respectively), DD (P < .001 and P < .001, respectively), and BMD (P = .002 and P < .001, respectively). In the multiple regression analysis, low MI (OR: 2.03, 95% CI: 1.14-3.61, P = .016) and DD (OR: 10.47, 95% CI: 5.59-19.59, P < .001) values remained significant for the prediction of mortality. Conclusion: BMD is a risk factor for mortality in patients with severe COVID-19, but cannot be used as an independent predictor. However, MI and DD can be used as independent predictors of mortality even in severe cases.

Obstetric Ultrasonography in Postgraduate Radiology Training: A National Survey Study.

ABSTRACT: There is no study in the literature that reveals the adequacy of obstetric ultrasonography (US) training in Turkey. We aimed to evaluate the adequacy of obstetric US training radiologists had received during their residency and determine how competent they considered themselves to be in this regard.A survey (27 items for residents, 21 items for specialists) was sent to all the radiology residents and specialists in Turkey through the mail list of the Turkish Society of Radiology.Ninety-one residents and 217 specialists participated in our study. Sixteen residents (17.6%) had received theoretical courses, 21 residents (23.1%) and 59 specialists (27.2%) had attended in-house obstetric US rotations, and 5 residents (5.5%) and 23 specialists (10.6%) had attended obstetric US rotations in another institution. When questioned separately for each trimester, only 11% to 36.3% of the residents stated that they took care of a sufficient number of patients. In general, 62.6% of the residents and 25.3% of the specialists did not consider themselves to be absolutely competent in obstetric US. The competency sources were specified as residency training by 44 residents (48.6%) and 55 specialists (25.3%), postgraduate training by 2 residents (2.2%) and 78 specialist (35.9%).In Turkey, current obstetric US training does not provide the experience that will allow physicians with radiology training to easily perform and interpret obstetric US. The main reasons for this situation include the limited number of patients the physicians took care of as a resident, insufficient rotation time, and lack of theoretical courses they attended.

Anthropometric and Clinical Analyses of the Distal Tibia, Posterior Tibial Tendon, and Flexor Digitorum Longus Tendon on MRI.

OBJECTIVE: To determine the gender and age differences in posterior tibial tendon (PTT), flexor digitorum longus tendon (FDLT), medial malleolar groove (MMG), and posterior, anterior, and total posterior malleolus (PMP, APM, and TPM, respectively) and evaluate the use of these parameters for posterior malleolus plating. STUDY DESIGN: Descriptive study. PLACE AND DURATION OF STUDY: Department of Radiology, Etimesgut Sehit Sait Ertürk State Hospital, Ankara, Turkey, from January to December 2020. METHODOLOGY: The magnetic resonance images (MRI) of the ankle were evaluated. PTT and FDLT thickness and width, MMG depth, width, length, and groove opening angle, and APM, TPM, and PPM length were measured. Receiver operating characteristic analysis was conducted to determine whether the variables differed between gender and age. RESULTS: The study included 103 patients (61 women, 42 men). For gender discrimination, the sensitivity, specificity, and cut-off values were 78.6%, 72.1%, and 7.48 mm, respectively. For the PTT width: 76.2%, 77%, and 3.88 mm, respectively; for the PTT thickness: 85.7%, 86.9%, and 40.41 mm, respectively; and for the APM length, the APM, TPM, and PPM length measurements were statistically and significantly differed between the genders (p<0.001). The APM/PPM ratio was 0.47±0.057 mm in women and 0.47±0.060 mm in men, and TPM/PPM was determined as 0.55±0.604 mm and 0.56±0.657 mm. There was a statistically significant weak positive correlation among the age, MMG length, and FDLT width. CONCLUSION: The groove depth and width, PTT and FDLT width and thickness, and TPM, PPM, and APM length can be used in gender prediction. The APM/PPM ratio can be calculated to determine the plating length in posterior malleolus fractures. KEY WORDS: Medial malleolar groove, Posterior tibial tendon, Flexor digitorum longus tendon, posterior malleolus, MRI.

Evaluation of the frequency of incidental findings and their clinical significance in multiparametric prostate magnetic resonance imaging examination.

Purpose: Conventional diagnostic methods have limitations in the diagnosis of prostate cancer (PCa); therefore, the use of multiparametric magnetic resonance imaging (mpMRI) in PCa has become widespread. We aimed to determine the frequency of IF detected in the mpMRI examination according to organ distribution and clinical significance. Material and methods: mpMRI examinations performed between January 2015 and 2020 based on the diagnosis or suspicion of PCa were retrospectively evaluated. IFs were divided into 2 groups, as genitourinary system and non- genitourinary system findings. In addition, IFs were also evaluated in 2 groups, as clinically significant and clinically non-significant. The patient population was divided into age ranges, and the frequency of IFs in these age ranges and their clinical significance were recorded. Results: The mpMRI examinations of 426 patients revealed a total of 321 Ifs, comprising 212 (49.8%) genitourinary (41.1%) and 189 (58.9%) extragenitourinary findings. The mean age of the patients was 63.53 ± 7.89 years. As the age increased, the rate of IFs increased (p = 0.001). However, there was no increase for the 75-year-old group compared to the 65-74-year-old age range (p = 0.853). There were a total of 22 (6.9%) clinically significant Ifs - 4 associated with the genitourinary system and 18 extragenitourinary. Conclusions: Although the rate of clinically significant IF was only 6.9%, this rate was high in patients, especially in those over the age of 65 years. It should be kept in mind that the early detection of these findings in the asymptomatic period will increase the survival and successful treatment of patients.

Is there a relationship between epicardial adipose tissue, inflammatory markers and prognosis in COVID-19 in patients under 65 years?

Aim: This study investigated the prognostic value of epicardial adipose tissue volume (EATV) attenuation (EATA) in patients admitted to the intensive care unit for COVID-19. Materials & methods: C-reactive protein (CRP), fasting blood glucose (FBG), neutrophil and lymphocyte counts, neutrophil-to-lymphocyte ratio (NLR) and lymphocyte-to-CRP ratio (LCR) were recorded. Receiver operator characteristic analysis was performed for EATV and EATA. Results: The study included 190 patients (65 deceased, 125 discharged, mean age 52.01 ± 9.6 years). The deceased group had significantly higher FBG and CRP values and significantly lower platelet count and LCR values. EATA (cut-off: -92.38 HU) and EATV (cut-off: 15.74 cm2) were significantly higher in the deceased group. EATV had a correlation with age, FBG, CRP, neutrophil, NLR and LCR, whereas EATA correlated with involvement on CT scan. Conclusion: EATV is associated with inflammatory parameters, whereas EATA is associated with CT scan involvement and can be used to predict mortality in young adult patients.

Calcified Peyronie's Disease Frequency on Computed Tomography.

OBJECTIVE: In computed tomography examinations performed for various reasons, calcified Peyronie's dis-ease can be incidentally detected. In this study, we aimed to evaluate the frequency of calcified Peyronie'sdisease incidentally detected in patients with abdominal computed tomography. MATERIAL AND METHODS: The images of male patients undergoing abdominal computed tomography betweenJanuary 2019 and January 2020 were retrospectively evaluated for the presence of calcified Peyronie's dis-ease. 1968 patients remained after subtracting computed tomography scans for insufficient evaluation of the penis, evaluated for the presence of calcified Peyronie's disease by two radiologists based on consensus. Thelocalization, side, and the number of plaques were recorded. RESULTS: The computed tomography examination of 1968 patients revealed calcified Peyronie's disease in 130 (6.6%) patients. Peyronie's disease was bilateral in 73 patients (56.1%), and unilateral in 57 (43.9%). A single plaque was observed in 44 (33.9%) patients, and multiple plaques in 86 (66.1%). The plaques werelocated in the middle portion of the penis in 98, proximal penis in 92, and distal penis in 31 cases. CONCLUSION: Calcified Peyronie's disease is incidentally detected on computed tomography examinations at a rate not rare. Peyronie's disease tends to be multiple, bilateral, and localized in the middle portion of thepenis.

CT-based Abdominal Adipose Tissue Area Changes in Patients Undergoing Adrenalectomy Due to Cushing's Syndrome and Non-functioning Adenomas.

BACKGROUND: The majority of Cushing's syndrome (CS) cases constitute patients with functional adrenal adenomas. In adrenal CS, visceral adipose tissue (VAT) area, VAT/subcutaneous adipose tissue (SAT), and VAT/total adipose tissue (TAT) ratios are expected to decrease in response to adrenalectomy, although no change is expected in non-functioning adrenal adenomas (NFA). OBJECTIVE: To evaluate the changes in VAT, SAT, TAT areas and VAT/SAT, VAT/TAT ratios using computed tomography (CT) in patients who underwent adrenalectomy due to adenomas. METHODS: Preoperative and postoperative CT of 32 patients (16 with CS and 16 with NFA) were retrospectively evaluated. The VAT, SAT, TAT areas were obtained from CT at the level of L1-2 intervertebral disc space, and the VAT/SAT, VAT/TAT ratios were calculated. The postoperative parameter changes in both groups were evaluated compared to the preoperative values. The level of statistical significance was considered as p<0.05. RESULTS: The time interval between preoperative and postoperative CT measurements were 10.37 months (6-17) in CS and 9.75 months (7-15) in NFA groups (p=073). Preoperative CT indicated that the patients with CS had larger VAT and TAT areas (p=0.03, p=0.02) but SAT remained unchanged (p=0.08). However, postoperative CT revealed that there was no difference between the two groups in terms of VAT, TAT, and SAT areas (p=0.87, p=0.36, p=0.14). Postoperatively, in patients with CS, there was a decrease in VAT and TAT areas (p=0.01 for both) and VAT/SAT and VAT/TAT ratios (p=0.03, p=0.02) but SAT remained unchanged (p=0.10). In patients with NFA, no change was detected in the postoperative SAT, TAT, and VAT areas (p=0.12, p=0.40, p=0.99) or the VAT/SAT and VAT/TAT ratios (p=0.38, p=0.62). CONCLUSIONS: Adrenalectomy is an effective treatment method leading to a decrease in the VAT, TAT areas, and VAT/SAT and VAT/TAT ratios in patients with cortisol producing adrenocortical adenoma. Thus, CT facilitates quantitative demonstration of the changes while evaluating the response of these patients to treatment.

A Case of Incidentally Detected Bladder Lipoma and a Review of the Literature.

BACKGROUND: Lipomas are benign fatty tumors made of fat tissue. Bladder lipomas are extremely rare. For this reason, it is necessary to be aware of the imaging features when incidentally detected in imaging. CASE REPORT: In the abdominal Computed Tomography (CT) performed as part of the follow-up examination of a 43-year-old patient, who had undergone surgery for adrenal adenoma five years earlier, a 14x9x8 mm smoothly marginated, ovoid-shaped, hypodense mass lesion with a homogeneous internal structure was detected in the anterior bladder wall. The pre-contrast density of the lesion was measured as -105 HU. The magnetic resonance imaging performed one year after the CT examination revealed a 14x9x8 intramural mass in the bladder wall, showing protrusion toward the lumen. The mass was observed to be markedly hypointense on fat-suppressed T1 and T2-weighted images and considered to be consistent with a bladder lipoma. DISCUSSION: Bladder lipomas are benign lesions that can vary in clinical presentations but usually cause hematuria. In imaging, bladder lipomas are present as homogeneous lesions containing macroscopic fat. The differential diagnosis of bladder lipomas includes other mesenchymal rare benign tumors that can arise from the submucosal layer of the urinary bladder including leiomyoma, hemangioma, plasmacytoma, fibroma, and neurofibroma. Only the liposarcoma and pelvic lipomatosis could show similar features. The less differentiated liposarcomas tend to present more heterogeneous enhancement, irregular-shaped margins, and infiltrative behaviour. Also, appropriate multiplanar reconstructions may allow the radiologist to determine if it is an extravesical pelvic lipomatosis. CONCLUSION: Using CT and MRI, the lesions that are rich in adipose tissue can be distinguished from other lesions, and their diagnosis can be made to a great extent. However, a histopathological examination is required for a definitive diagnosis.

Evaluation of multiparametric prostate magnetic resonance imaging findings in patients with a Gleason score of 6 in transrectal ultrasonography-guided biopsy.

PURPOSE: We aimed to evaluate prostate multiparametric magnetic resonance imaging (mpMRI) findings of patients with a Gleason score (GS) of 6 and effectiveness of MRI based on the final pathology result in patients undergoing radical prostatectomy (RP). MATERIAL AND METHODS: mpMRI findings of 80 patients who had a GS of 3 + 3 and who underwent mpMRI were evaluated retrospectively. The mpMRI were scored according to the PIRADS v2.1 guidelines. The patients were divided into those with a high probability of clinically significant cancer (CSC) (PI-RADS 4-5) and those with a low probability of CSC (PI-RADS 2-3). RESULTS: Of the 80 patients, 33.8% had PI-RADS 2-3, and 66.2% had PI-RADS 4-5 lesions. There was a significant difference between the groups in prostate specific antigen (PSA) value, PSA density, patient age, and tumour percentage on biopsy. When the pathology results were taken as the gold standard in the group that underwent RP, sensitivity, specificity, and accuracy of mpMRI were calculated as 94.74%, 100%, and 96.3%, respectively, an increase in the final GS was found in 9 (33.3%) of the 27 patients, and 70.35% of patients were identified as having CSC. CONCLUSIONS: PI-RADS 4-5 scores have high sensitivity and negative predictive value in the diagnosis of CSC. mpMRI is a reliable and non-invasive diagnostic method that can complement biopsy results in decision-making in patients who are initially evaluated as low risk.

Are the washout values currently accepted for lesion characterization in dedicated adrenal CT adequate for diagnosis?

PURPOSE: We aimed to investigate the accuracy of density characteristics and washout values of lesions detected on computed tomography (CT) at the cutoff values obtained from the literature by taking the pathological results of adrenalectomy specimens as reference and to determine the cutoff values of parameters evaluated on CT for the differentiation of adenoma and nonadenoma lesions in the study group. METHODS: Hospital records and standard CT imaging data (noncontrast early phase [65 s] and late phase [15 min] ) of 84 patients with 87 lesions who underwent adrenalectomy between January 2012 and December 2018 were retrospectively reevaluated by two radiologists in consensus. The patients were categorized as having adenoma and nonadenoma lesions according to the pathology results. The sensitivity, specificity and diagnostic accuracy of CT parameters (density values and washout percentages) were evaluated. Differences in the CT parameters (size, noncontrast and early-late enhancement density and absolute and relative washout values) were investigated. The optimal cutoff values of CT parameters were determined by ROC analysis. RESULTS: Noncontrast CT had a specificity of 87.75% and 95.9%, sensitivity of 60% and 48.6%, diagnostic accuracy of 77.7% and 89.47% for adenomas, at the cutoff values of ≤10 HU and ≤0 HU, respectively. For absolute washout value ≥ 60%, the sensitivity, specificity and accuracy were 64.7%, 52.38% and 56.75%, respectively; while these rates were 76.47%, 56.52% and 62.16%, respectively, for relative washout value ≥40%. Adenomas and nonadenomas showed significant difference in terms of size (p < 0.0001), unenhanced attenuation (p < 0.0001), relative washout (p = 0.020) and delay enhancement (p < 0.001). But there were no differences in terms of absolute washout (p = 0.230) and early enhancement (p = 0.264). The cutoff values for the differentiation of adenomas and nonadenomas were as follows: size ≤44 mm, noncontrast density <20 HU, early-phase density ≥45 HU, delayed-phase density ≤44 HU, absolute washout 74.83% and relative washout 57.76%. CONCLUSION: The current washout criteria used in the differentiation of adenoma and nonadenoma lesions in dynamic CT imaging can give false negative and positive results. According to the existing criteria, the most reliable parameter in adenoma-nonadenoma differentiation is ≤ 0 HU noncontrast CT density value.

Birt-hogg-Dubé Syndrome Incidentally Identified in a Potential Liver Donor.

BACKGROUND: Birt-Hogg-Dubé Syndrome (BHDS), an autosomal dominant hereditary condition, occurs due to mutations in the gene encoding folliculin (FLCN) in the short arm of the 17th chromosome characterized by lung cysts with specific skin findings and renal cell carcinoma. Patients have usually complaints related to dyspnea and chest pain due to pneumothorax but they may be asymptomatic due to wide phenotypic heterogeneity. Herein, we report the imaging findings of a case 32-year-old male with BHDS without any symptom who was diagnosed incidentally by computed tomography (CT) due to organ donation. CASE REPORT: In a 32-year-old male patient evaluated as a potential liver donor, CT was performed for preoperative preparation. The patient's medical history was unremarkable. In the CT examination, multiple air cysts of different sizes in both lungs were observed and also, a 7-cm solid renal mass of the right kidney was observed in the dynamic examination. Due to a large number of lung cysts and the presence of solid renal tumors at a young age, BHDS was considered. The patient underwent partial nephrectomy, and the pathology result was hybrid oncocytic-chromophobe renal cell carcinoma. In the genetic examination, a heterozygous germline mutation was detected in the 11th exon of the FLCN gene. CONCLUSION: While potential organ donors are generally healthy and asymptomatic individuals, incidental lesions can be detected in the donor organ or other organs in the examination area during radiological imaging. Although most incidental lesions are benign, important clinical conditions can rarely be observed, as in our case. Familial and syndromic conditions should also be considered for the presence of solid renal masses incidentally detected at a young age. To the best of our knowledge, this is the first reported case of BHDS in English literature who was diagnosed incidentally on computed tomography for being a living liver donor.

A Rare Case of Ureteral Diverticulum Incidentally Detected During Angiography.

BACKGROUND: A ureteral diverticulum (UD) is a rare urological malformation characterized by the saccular enlargement of the ureteral wall. It can be of different sizes and in various localizations. In the literature, three types of UD have been defined as abortive bifid ureter, congenital, and acquired. CASE REPORT: In a 65-year-old male patient, an enlargement was incidentally detected in the distal part of the right ureter on fluoroscopy during the passage of the contrast agent applied during angiography. The medical history of the patient was not remarkable; thus, computed tomography (CT) was performed to investigate the etiology. A dilated tubular structure separate from the ureter was observed in the middle part of the right ureter on CT, clearer in the excision phase. This tubular structure distally connected with the ureter and was consistent with the abortive bifid ureter type of UD. DISCUSSION: UD may present with renal colic, hematuria, and upper urinary tract infections, or it may be asymptomatic as in our case. Asymptomatic cases are usually incidentally detected during radiological imaging. Although treatment is not required for these patients, surgical treatment may be required in the presence of symptoms. CONCLUSION: UD is an entity that can be asymptomatic until adulthood and may be detected incidentally in radiological evaluations. UD should be kept in mind when the cystic lesion associated with the ureter is detected in radiological examination. Excretory phase CT/CT urography noninvasive imaging method must be preferred to evaluate the relationship of the lesion with the ureter.