High Entropy Pr-Doped Hollow NiFeP Nanoflowers Inlaid on N-rGO for Efficient and Durable Electrodes for Lithium-Ion Batteries and Direct Borohydride Fuel Cells.

The selection and design of new electrode materials for energy conversion and storage are critical for improved performance, cost reduction, and mass manufacturing. A bifunctional anode with high catalytic activity and extended cycle stability is crucial for rechargeable lithium-ion batteries and direct borohydride fuel cells. Herein, a high entropy novel three-dimensional structured electrode with Pr-doped hollow NiFeP nanoflowers inlaid on N-rGO was prepared via a simple hydrothermal and self-assembly process. For optimization of Pr content, three (0.1, 0.5, and 0.8) different doping ratios were investigated. A lithium-ion battery assembled with NiPr0.5 FeP/N-rGO electrode achieved an outstanding specific capacity of 1.61 Ah g-1 at 0.2 A g-1 after 100 cycles with 99.3 % Coulombic efficiencies. A prolonged cycling stability of 1.02 Ah g-1 was maintained even after 1000 cycles at 0.5 A g-1 . In addition, a full cell battery with NiPr0.5 FeP/N-rGO∥LCO (Lithium cobalt oxide) delivered a promising cycling performance of 0.52 Ah g-1 after 200 cycles at 0.15 A g-1 . Subsequently, the NiPr0.5 FeP/N-rGO electrode in a direct borohydride fuel cell showed the highest peak power density of 93.70 mW cm-2 at 60 °C. Therefore, this work can be extended to develop advanced electrode for next-generation energy storage and conversion systems.

Ondansetron/Cyclodextrin inclusion complex nanofibrous webs for potential orally fast-disintegrating antiemetic drug delivery.

Ondansetron (ODS) is an effective antiemetic drug which suffers from limited solubility and bioavailability during oral administration due to first-pass metabolism. However, these limitations can be mitigated through inclusion complexation with cyclodextrins (CDs). In this study, we have reported the electrospinning of polymer-free, free-standing ODS/CD nanofibrous webs (NW), a promising approach for developing a fast-disintegrating delivery system of an antiemetic drug molecule. Highly water soluble hydroxypropyl-beta-cyclodextrins (HPßCD) were used as both complexation agent and electrospinning matrix. The computational study revealed that the 1/2 (drug/CD) stoichiometry was more favorable compared to 1/1. The ODS/HPßCD NW was obtained with higher loading efficiency (∼96 %) compared to the control sample of ODS/polyvinyl alcohol (PVA) NW (∼80 %). The amorphous distribution of ODS raised by complexation and the highly water-soluble nature of HPßCD resulted into faster and better release profile and quite faster disintegration property (∼2 s) in artificial saliva than polymeric ODS/PVA NW. Here, ODS/HPßCD NW was generated in the absence of a toxic solvent or chemical to enable the drug loading in an amorphous state. From all reasons above, ODS/HPßCD NW might be a promising alternative to the polymeric based systems for the purpose of fast-disintegrating oral drug delivery.