RESUMEN
PURPOSE OF REVIEW: The aim of this paper is to review psychiatric manifestations, comorbidities, and psychopharmacological management in individuals with acute porphyria (AP). RECENT FINDINGS: Recent literature begins to clarify associations between AP, schizophrenia, bipolar disorder, and other psychopathology. Broad psychiatric symptoms have been associated to acute porphyria (AP) and correspond to a spectrum of heterogeneous manifestations such as anxiety, affective alterations, behavioral changes, personality, and psychotic symptoms. These symptoms may be difficult to identify as being related to porphyria since symptoms may arise at any time during the disease process. In addition, these patients may present psychiatric conditions secondary to the disease, such as adjustment disorder and substance use disorders. Timely diagnosis and appropriate treatment of psychiatric manifestations positively impact the course of the disease.
Asunto(s)
Trastornos Mentales/etiología , Porfiria Intermitente Aguda/psicología , Analgésicos/uso terapéutico , Antiinflamatorios no Esteroideos/uso terapéutico , Comorbilidad , Humanos , Trastornos Mentales/fisiopatología , Trastornos Mentales/terapia , Personalidad , Porfiria Intermitente Aguda/complicaciones , PsicopatologíaRESUMEN
OBJETIVOS :analizar las capacidades de investigación en determinantes sociales de la salud (DSS) existentes en Colombia a partir de la información registrada en la plataforma de Colciencias entre enero del 2005 y abril del 2012, así como la opinión de coordinadores de grupos de investigación. METODOLOGIA: se diseñó un estudio observacional descriptivo sobre la base Scienti de Colciencias, específicamente sobre aspectos relacionados con los grupos, los investigadores y la producción científica sobre DSS. Se complementó con cuestionarios y grupos focales con previo consentimiento informado y estudio del sistema nacional de investigación. RESULTADOS: entre los 65 grupos registrados en el Programa de Ciencias de la Salud de Colciencias (6%) se han publicado 123 productos, mediante artículo científico en idioma español (48%). Privilegian estudios de poblaciones demográficamente relevantes sobre sistemas de salud, inequidad en salud y enfermedades prevalentes, elaborados con métodos empírico analíticos y algunos en proyectos en red de carácter nacional. Las dificultades se refieren al escaso respaldo político e institucional local y nacional para investigar en DSS, poca interacción con formuladores de políticas y con otros grupos en otros idiomas. CONCLUSIONES :predominan los estudios con el enfoque propuesto por la Comisión de Determinantes Sociales de la Salud en 2005. Recomendaciones: fortalecer capacidades de investigación en DSS desde diversos enfoques, especialmente los latinoamericanos, desarrollar proyectos colaborativos en red y movilizar acción colectiva con incidencia en políticas de investigación en salud pro equidad.
OBJECTIVE:this paper analyzes the ability to research on social determinants in health (sdh) in research groups registered in the Colciencias platform from January 2005 to June 2012, as well as the opinion of coordinators of research groups. METHODOLOGY a descriptive study to review the platform about information on research groups, researchers and research products on sdh was designed. It was contrasted with semistructured interviews and focus groups targeted at researchers with informed consent, and study of the national research system. RESULTS : the 65 groups registered in the Colciencias Program of Health Sciences (6%) have published 123 products by means of scientific articles in Spanish (48%). Studies on demographically relevant populations about health systems, health inequity and prevalent illnesses became conspicuous. They were accomplished through analytical and empirical methods and some projects in the national network were approached. The difficulties identified were scarce political and institutional support for local and national research in sdh an reduced interaction with policy makers and other groups using other languages . CONCLUSIONS : studies based on the approach proposed by the Commission on Social Determinants of Health in 2005 were prominent. Recommendations: it is essential to strengthen research capacities in various approaches to sdh, especially Latin American approaches, to develop collaborative projects and networking and to mobilize collective action network with policy advocacy for equitable health research.