Calidad de vida en adultos mayores cuidadores de nietos del norte y suroeste de México / Quality of life in older caregivers of grandchildren in northern and southwestern Mexico

Objetivo: Determinar la relación de las características personales con la calidad de vida en adultos mayores cuidadores de nietos del norte y suroeste de México. Métodos: Descriptivo-correlacional y comparativo, con una muestra de 326 adultos mayores cuidadores de nietos, recolectado mediante muestreo a conveniencia y que cumpla con los criterios de inclusión. Se aplicó una cedula de datos personales y la escala de Calidad de Vida Autopercibida en Adultos Mayores en Comunidad (α=0.93). Los datos se analizaron con estadística descriptiva e inferencial como pruebas de U de Mann-Whitney, Chi cuadrada y Spearman. Contó con la aprobación del Comité de ética, acatándose los reglamentos nacionales e internacionales. Resultados: La población tuvo una de M=68.56 años, siendo el 54.9% hombre y el 45.1% mujer, con una de M=9.10 horas del cuidado del nieto. Se halló asociación de la calidad de vida con la zona geográfica de México (Chi=35.695, p<0.05). Se observó relación de la edad (r=-0.155) y el número de hijos (r=-0.279) con la calidad de vida. Conclusiones: Se observó que, a mayor edad y número de hijos, menor calidad de vida. De igual manera, la calidad de vida se asocia con la zona geográfica. Se recomienda prestar atención en la salud física, psicológica y social de este grupo vulnerable. (AU)

Objective: Determine the relationship of personal characteristics with the quality of life in elderly people who care for their grandchildren from northern and southwestern Mexico. Method: Descriptive-correlational and comparative method, using a sample of 326 older adults who take care of their grandchildren; this sample was collected through convenience sampling and making sure that people met the inclusion criteria. A personal data card and the self-perceived quality of life scale were applied in elderly people in the community (α=0.93). The data were analyzed with descriptive and inferential statistics such as U Mann-Whitney, Chi Square, and Spearman tests. It was approved by the Ethics Committee, in compliance with national and international regulations. Results: The population had an M of 68.56 years, being 54.9% male and 45.1% female, with one M of 9.10 hours of care of the grandchild. The association of quality of life with the geographical area of Mexico was found (Chi=35,695, p<0.05). The relationship between age (r=-0,155) and number of children (r=-0,279) and quality of life was seen. Conclusions: It was seen that the older the age and number of children, the lower the quality of life. Similarly, quality of life is associated with the geographical area. It is recommended that care be given within physical, psychological, and social health of this vulnerable group. (AU)

Purshia plicata Triggers and Regulates Proteins Related to Apoptosis in HeLa Cancer Cells.

Cervical cancer represents a public health problem, develops resistance to traditional therapies and cost-of-treatment is high. These disadvantages have led to the search for alternative bioactive-compound-based therapies. Said bioactive compounds include phenolic compounds, flavonoids, and tannins. The present study aimed to evaluate the therapeutic effect of a P. plicata extract on the HeLa cell line. Viability and apoptosis assays were run on the two cell lines treated with the extract. The peptides, up- and down-expressed in both cell lines, were identified by PDQuest analysis software and high-performance liquid chromatography/mass spectrometry/mass spectrometry (HPLC/MS/MS). Our results show that a 500 mg/L treatment deregulated cell viability, with different apoptotic morphologies observed which are associated with the presence of bio-compounds, which up- and down-regulated the peptides. In conclusion, P. plicata regulates proteins associated with apoptosis in HeLa cancer cells.