RESUMEN
BACKGROUND: To determine the immunohistochemical expression levels of the somatostatin receptor subtypes 2 and 5 (Sst2 and Sst5) in patients with colorectal cancer (CRC) and to investigate the association of Sst2 and Sst5 expression with clinicopathological parameters. MATERIALS AND METHODS: A retrospective analysis of formalin-fixed and paraffin-embedded CRC surgical specimens from 81 patients assessed by immunohistochemistry for Sst2 and Sst5 expression. RESULTS: Sst2 and Sst5 expression levels showed significant, negative association with CRC invasion and liver metastasis (P values < 0·05) while Sst2 also showed significantly increased expression in lower-grade tumours as well as in tumours located in the rectum (P values < 0·05). Patients with CRC expressing either Sst2 or Sst5 had significantly longer survival rates (P values < 0·05), although Sst expression was not found to be an independent predictor of survival after controlling for other known prognostic clinicopathological variables (P values > 0·05). CONCLUSIONS: The present data confirm the relationship of Sst2 and Sst5 expression levels with reduced tumour aggressiveness.
Asunto(s)
Neoplasias Colorrectales/metabolismo , Receptores de Somatostatina/metabolismo , Células Cultivadas , Neoplasias Colorrectales/patología , Femenino , Humanos , Inmunohistoquímica , Masculino , Estudios RetrospectivosRESUMEN
PURPOSE: This study evaluated the frequency of metastases to supramandibular facial lymph nodes (SFLNs) in patients with squamous cell carcinoma (SCC) of the oral cavity. PATIENTS AND METHODS: SFLNs were identified and removed during neck dissection from 43 patients with oral SCC. All of them were histopathologically and immunohistochemically examined, to detect possible metastases and micrometastases. RESULTS: Metastases to SFLNs were present in 6 patients (13.95%). Metastases were much more common among patients with palpable neck nodes, larger size of the primary site, advanced TNM stage, and greater age and those in whom the primary site was located in the mucosa of the alveolar ridge of the mandible. CONCLUSIONS: Surgical procedures in the region of the SFLNs must be performed very carefully, because of their close relation with the marginal mandibular nerve. In patients with oral SCC and palpable neck nodes, those with advanced disease, and those in whom the primary site is located in the mucosa of the alveolar ridge of the mandible, removal of SFLNs must be considered.
Asunto(s)
Carcinoma de Células Escamosas/secundario , Neoplasias Faciales/secundario , Neoplasias de la Boca/patología , Disección del Cuello/métodos , Adulto , Anciano , Anciano de 80 o más Años , Neoplasias Faciales/patología , Neoplasias Faciales/cirugía , Traumatismos del Nervio Facial/prevención & control , Femenino , Humanos , Ganglios Linfáticos/patología , Metástasis Linfática , Masculino , Persona de Mediana Edad , Estadificación de Neoplasias , Estudios ProspectivosRESUMEN
We present a vagal paraganglioma in a 74-year-old woman, who presented with dysphagia, dysarthria and hoarseness.
