[A preclinical study of ximedone]. / Dolkinicheskoe issledovanie ksimedona.

Pharmacotoxicological properties of ximedone, a new pyrimidine derivative, were studied experimentally on animals of various species. In the enteral regimen the drug had a favourable effect on thermal burns and postoperative cutaneous and gastric wounds. The results enabled to recommend ximedone for the clinical practice.

[The use of xymedon in treating trophic ulcers of the lower extremities]. / Ispol'zovanie ksimedona v lechenii troficheskikh iazv nizhnikh konechnostei.

A new derivative of pyrimidine--Ximedon--was included in the complex treatment of 50 patients with trophic ulcers of lower extremities. The use of Ximedon resulted in shifts of homeostasis, of the cellular composition of the wound discharge, of metabolism of nucleic acids and activity of enzymes of the granulation tissue. Periods of the preoperative preparation of the patients became shorter. The immediate and long-term results obtained after such treatment were more stable.

[Ximedone in the treatment of patients with burns]. / Primenenie ksimedona v lechenii obozhzhennykh.

The authors studied xymedone, a new medicamentous agent from the group of pyrimidine derivatives. It was prescribed per os, 0.5 g taken three times daily. The experimental group consisted of 52 patients with IIIA and B degree thermal burns covering an area of 10 to 40%. The comparative appraisal was conducted with patients (60) treated by a complex of measures including methyluracil. Analysis of the obtained data showed a statistically significant, as compared to the controls, more rapid restoration of the peripheral blood parameters, decrease of C-reactive protein and level of sialic acid, and increase of total protein content and its gamma globulin fraction. Xymedone contributed to correction of blood dysproteinemia and produced an active effect on nucleic acid metabolism; the level of nucleic acids in the cells of the granulation tissue was much higher in the experimental group after treatment than in the controls. The normal ratio of T- and B-lymphocytes was restored and the phagocytosis indices grew. The production of coagulation and anticoagulation factors became normal, which coincided with cleaning of the granulations from fibrinous deposits and disappearance of the pathological predisposition to bleeding and easy damage of the granulation tissue. Under the effect of the agent the patients' appetite improved, the duration of the dehydration phase reduced, the rate of growth of microgranular granulations and epithelium increased, and the incidence of keloid cicatrices decreased. No unfavorable side effects of the agent were encountered. Xymedone is recommended for wide use in medical practice.

[Participation of alveolar macrophages in the catabolism of fibrinogen and fibrin]. / Uchastie al'veoliarnykh makrofagov v katabolizme fibrinogena i fibrina.

The penetration of FITC-fibrinogen in rabbit alveolar macrophages depends on Ca2+ and Mg2+. Therefore there is reason to believe the process is not restricted only by diffusion on concentration gradient, but pinocytosis takes place, which depends Ca2+. The absorption of FITC-label from fibrin by alveolar macrophages is more slow than from fibrinogen. Soluble high-molecular products of fibrin degradation can be trapped by pinocytosis. On the basis of such studies it was assumed that degradation of fibrin proceeds parietally.

[The expression and degradation of tissue thromboplastin]. / Ekspressiia i degradatsiia tkanevogo tromboplastina.

The highest disintegration rate of FITC-thromboplastin occurred in the organs rich in RES-cells. The half-disintegration period was found to be 58 +/- 12 min in liver, 98 +/- 48 min in spleen, 262 +/- 36 min in kidneys, 310 +/- 114 min in lung microcirculatory flow. Several pathways were found of the thromboplastin tissue local disintegration mediated via proteolytic and lipolytic enzymes released from endothelial cells and leucocytes: endocytosis of RES-cells followed by intracellular cleavage by lysosomal enzymes; and gradual blood transfer of thromboplastin particles from the organs with moderate disintegration rate to the organs capable of rapid disintegration.