RESUMEN
Background Nonalcoholic fatty liver disease (NAFLD) is the most frequent chronic liver injury around the world. It is associated with metabolic syndrome and cardiovascular diseases. Objective To evaluate the frequency and relevance of NAFLD in patients with coronary artery disease (CAD). Methods Patients from a Brazil Northeast area, who underwent elective coronary angiography (CAG) from 2009 to 2010 were included. All of them had suspicion of CAD. Criteria to CAD: presence of obstructive lesions in the epicardial coronary arteries, or in their major branches. NAFLD criteria: presence of hepatic steatosis on ultrasound; exclusion of other liver diseases; ethanol intake ≤ 20g/day. Statistics analysis included Independent t-test, Mann-Whitney and Pearson's chi-squared test. Multivariate regression analysis measured the relationship between the risk factors and the concomitant presence of CAD and NAFLD. Results A total of 244 patients were evaluated: 63.5% had CAD and 42.2% had NAFLD. NAFLD was observed in 43.9% of the CAD patients. The regression analysis showed that the relationship between CAD and NAFLD was positively correlated with HOMA-IR ≥3.0 or insulin resistance and overweight/obesity. Conclusion NAFLD was frequent among CAD patients; insulin resistance and overweight/obesity were the most relevant risk factors related to the association NAFLD and CAD. The results suggest that patients with CAD should be evaluated for NAFLD.
Asunto(s)
Enfermedad de la Arteria Coronaria/complicaciones , Síndrome Metabólico/complicaciones , Enfermedad del Hígado Graso no Alcohólico/complicaciones , Brasil/epidemiología , Angiografía Coronaria , Enfermedad de la Arteria Coronaria/epidemiología , Femenino , Humanos , Resistencia a la Insulina , Masculino , Síndrome Metabólico/epidemiología , Persona de Mediana Edad , Enfermedad del Hígado Graso no Alcohólico/epidemiología , Obesidad/complicaciones , Obesidad/epidemiología , Factores de RiesgoRESUMEN
Background Nonalcoholic fatty liver disease (NAFLD) is the most frequent chronic liver injury around the world. It is associated with metabolic syndrome and cardiovascular diseases. Objective To evaluate the frequency and relevance of NAFLD in patients with coronary artery disease (CAD). Methods Patients from a Brazil Northeast area, who underwent elective coronary angiography (CAG) from 2009 to 2010 were included. All of them had suspicion of CAD. Criteria to CAD: presence of obstructive lesions in the epicardial coronary arteries, or in their major branches. NAFLD criteria: presence of hepatic steatosis on ultrasound; exclusion of other liver diseases; ethanol intake ≤ 20g/day. Statistics analysis included Independent t-test, Mann-Whitney and Pearson’s chi-squared test. Multivariate regression analysis measured the relationship between the risk factors and the concomitant presence of CAD and NAFLD. Results A total of 244 patients were evaluated: 63.5% had CAD and 42.2% had NAFLD. NAFLD was observed in 43.9% of the CAD patients. The regression analysis showed that the relationship between CAD and NAFLD was positively correlated with HOMA-IR ≥3.0 or insulin resistance and overweight/obesity. Conclusion NAFLD was frequent among CAD patients; insulin resistance and overweight/obesity were the most relevant risk factors related to the association NAFLD and CAD. The results suggest that patients with CAD should be evaluated for NAFLD. .
Contexto Doença hepática gordurosa não alcoólica (DHGNA) é uma das mais frequentes hepatopatias crônicas da atualidade. Associa-se à síndrome metabólica e doenças cardiovasculares. Objetivo Avaliar a frequência e relevância da DHGNA em pacientes com doença arterial coronariana (DAC). Métodos Foram avaliados pacientes de uma área do Nordeste de Brasil, submetidos à angiografia coronariana, com suspeita de DAC, entre 2009-2010. Critérios para DAC: presença de lesões obstrutivas em artérias coronárias epicárdicas ou seus principais ramos. Critérios para DHGNA: esteatose hepática na ultrassonografia; exclusão de outras doenças hepáticas; ingestão de etanol ≤20g/dia. Análise estatística incluiu os testes t, Mann-Whitney e qui-quadrado de Pearson. Análise de regressão multivariada mediu a força da correlação entre fatores de risco e concomitância de DAC e DHGNA. Resultados Foram avaliados 244 pacientes submetidos à angiografia coronariana: 63,5% apresentavam DAC e 42,2% DHGNA. DHGNA foi observada em 43,9% dos doentes com DAC. A análise de regressão mostrou que a possibilidade de ocorrência concomitante de DAC e DHGNA foi positivamente correlacionadas à resistência a insulina e ao sobrepeso/obesidade. Conclusão DHGNA foi frequente entre os pacientes com DAC; resistência à insulina e sobrepeso/obesidade foram os mais relevantes fatores de risco relacionados à associação DHGNA e DAC. Os dados sugerem que pacientes com DAC devem ser avaliados para DHGNA. .