Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 13 de 13
Filtrar
1.
AJNR Am J Neuroradiol ; 41(5): 815-821, 2020 05.
Artículo en Inglés | MEDLINE | ID: mdl-32327434

RESUMEN

BACKGROUND AND PURPOSE: Despite the improved prognostic relevance of the 2016 WHO molecular-based classification of lower-grade gliomas, variability in clinical outcome persists within existing molecular subtypes. Our aim was to determine prognostically significant metrics on preoperative MR imaging for lower-grade gliomas within currently defined molecular categories. MATERIALS AND METHODS: We undertook a retrospective analysis of 306 patients with lower-grade gliomas accrued from an institutional data base and The Cancer Genome Atlas. Two neuroradiologists in consensus analyzed preoperative MRIs of each lower-grade glioma to determine the following: tumor size, tumor location, number of involved lobes, corpus callosum involvement, hydrocephalus, midline shift, eloquent cortex involvement, ependymal extension, margins, contrast enhancement, and necrosis. Adjusted hazard ratios determined the association between MR imaging metrics and overall survival per molecular subtype, after adjustment for patient age, patient sex, World Health Organization grade, and surgical resection status. RESULTS: For isocitrate dehydrogenase (IDH) wild-type lower-grade gliomas, tumor size (hazard ratio, 3.82; 95% CI, 1.94-7.75; P < .001), number of involved lobes (hazard ratio, 1.70; 95% CI, 1.28-2.27; P < .001), hydrocephalus (hazard ratio, 4.43; 95% CI, 1.12-17.54; P = .034), midline shift (hazard ratio, 1.16; 95% CI, 1.03-1.30; P = .013), margins (P = .031), and contrast enhancement (hazard ratio, 0.34; 95% CI, 0.13-0.90; P = .030) were associated with overall survival. For IDH-mutant 1p/19q-codeleted lower-grade gliomas, tumor size (hazard ratio, 2.85; 95% CI, 1.06-7.70; P = .039) and ependymal extension (hazard ratio, 6.34; 95% CI, 1.07-37.59; P = .042) were associated with overall survival. CONCLUSIONS: MR imaging metrics offers prognostic information for patients with lower-grade gliomas within molecularly defined classes, with the greatest prognostic value for IDH wild-type lower-grade gliomas.


Asunto(s)
Neoplasias Encefálicas/diagnóstico por imagen , Neoplasias Encefálicas/patología , Glioma/diagnóstico por imagen , Glioma/patología , Adolescente , Adulto , Anciano , Neoplasias Encefálicas/mortalidad , Femenino , Glioma/mortalidad , Humanos , Isocitrato Deshidrogenasa/genética , Imagen por Resonancia Magnética/métodos , Masculino , Persona de Mediana Edad , Mutación , Pronóstico , Estudios Retrospectivos , Adulto Joven
2.
AJNR Am J Neuroradiol ; 40(7): 1149-1155, 2019 07.
Artículo en Inglés | MEDLINE | ID: mdl-31248860

RESUMEN

BACKGROUND AND PURPOSE: Diffuse lower-grade gliomas are classified into prognostically meaningful molecular subtypes. We aimed to determine the impact of surgical resection on overall survival in lower-grade glioma molecular subtypes. MATERIALS AND METHODS: For 172 patients with lower-grade gliomas (World Health Organization grade II or III), pre- and postsurgical glioma volumes were determined using a semiautomated segmentation software based on FLAIR or T2-weighted MR imaging sequences. The association of pre- and postsurgical glioma volume and the percentage of glioma resection with overall survival was determined for the entire cohort and separately for lower-grade glioma molecular subtypes based on isocitrate dehydrogenase (IDH) and 1p/19q status, after adjustment for age, sex, World Health Organization grade, chemotherapy administration, and radiation therapy administration. RESULTS: For the entire cohort, postsurgical glioma volume (hazard ratio, 1.80; 95% CI, 1.18-2.75; P = .006) and the percentage of resection (hazard ratio, 3.22; 95% CI, 1.79-5.82; P < .001) were associated with overall survival. For IDH-mutant 1p/19q-codeleted oligodendrogliomas, the percentage of resection (hazard ratio, 6.69; 95% CI, 1.57-28.46; P = .01) was associated with overall survival. For IDH-mutant 1p/19q-noncodeleted astrocytomas, presurgical glioma volume (hazard ratio, 3.20; 95% CI, 1.22-8.39; P = .018), postsurgical glioma volume (hazard ratio, 2.33; 95% CI, 1.32-4.12; P = .004), and percentage of resection (hazard ratio, 4.34; 95% CI, 1.74-10.81; P = .002) were associated with overall survival. For IDH-wild-type lower-grade gliomas, pre-/postsurgical glioma volume and percentage of resection were not associated with overall survival. CONCLUSIONS: The extent of surgical resection has a differential survival impact in patients with lower-grade gliomas based on their molecular subtype. IDH-mutant lower-grade gliomas benefit from a greater extent of surgical resection, with the strongest impact observed for IDH-mutant 1p/19q-noncodeleted astrocytomas.


Asunto(s)
Neoplasias Encefálicas/genética , Neoplasias Encefálicas/mortalidad , Neoplasias Encefálicas/cirugía , Glioma/genética , Glioma/mortalidad , Glioma/cirugía , Adulto , Femenino , Humanos , Isocitrato Deshidrogenasa/genética , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , Mutación , Pronóstico , Estudios Retrospectivos
3.
AJNR Am J Neuroradiol ; 40(3): 426-432, 2019 03.
Artículo en Inglés | MEDLINE | ID: mdl-30705071

RESUMEN

BACKGROUND AND PURPOSE: Isocitrate dehydrogenase (IDH)-mutant lower grade gliomas are classified as oligodendrogliomas or diffuse astrocytomas based on 1p/19q-codeletion status. We aimed to test and validate neuroradiologists' performances in predicting the codeletion status of IDH-mutant lower grade gliomas based on simple neuroimaging metrics. MATERIALS AND METHODS: One hundred two IDH-mutant lower grade gliomas with preoperative MR imaging and known 1p/19q status from The Cancer Genome Atlas composed a training dataset. Two neuroradiologists in consensus analyzed the training dataset for various imaging features: tumor texture, margins, cortical infiltration, T2-FLAIR mismatch, tumor cyst, T2* susceptibility, hydrocephalus, midline shift, maximum dimension, primary lobe, necrosis, enhancement, edema, and gliomatosis. Statistical analysis of the training data produced a multivariate classification model for codeletion prediction based on a subset of MR imaging features and patient age. To validate the classification model, 2 different independent neuroradiologists analyzed a separate cohort of 106 institutional IDH-mutant lower grade gliomas. RESULTS: Training dataset analysis produced a 2-step classification algorithm with 86.3% codeletion prediction accuracy, based on the following: 1) the presence of the T2-FLAIR mismatch sign, which was 100% predictive of noncodeleted lower grade gliomas, (n = 21); and 2) a logistic regression model based on texture, patient age, T2* susceptibility, primary lobe, and hydrocephalus. Independent validation of the classification algorithm rendered codeletion prediction accuracies of 81.1% and 79.2% in 2 independent readers. The metrics used in the algorithm were associated with moderate-substantial interreader agreement (κ = 0.56-0.79). CONCLUSIONS: We have validated a classification algorithm based on simple, reproducible neuroimaging metrics and patient age that demonstrates a moderate prediction accuracy of 1p/19q-codeletion status among IDH-mutant lower grade gliomas.


Asunto(s)
Algoritmos , Neoplasias Encefálicas/clasificación , Glioma/clasificación , Neuroimagen/métodos , Adulto , Anciano , Astrocitoma/clasificación , Astrocitoma/diagnóstico , Astrocitoma/genética , Neoplasias Encefálicas/diagnóstico por imagen , Neoplasias Encefálicas/genética , Cromosomas Humanos Par 1/genética , Estudios de Cohortes , Femenino , Glioma/diagnóstico por imagen , Glioma/genética , Humanos , Isocitrato Deshidrogenasa/genética , Imagen por Resonancia Magnética/métodos , Masculino , Persona de Mediana Edad , Mutación , Oligodendroglioma/clasificación , Oligodendroglioma/diagnóstico por imagen , Oligodendroglioma/genética , Estudios Retrospectivos , Adulto Joven
4.
Artículo en Inglés | MEDLINE | ID: mdl-26603828

RESUMEN

Duloxetine is an effective treatment for oxaliplatin-induced painful chemotherapy-induced peripheral neuropathy (CIPN). However, predictors of duloxetine response have not been adequately explored. The objective of this secondary and exploratory analysis was to identify predictors of duloxetine response in patients with painful oxaliplatin-induced CIPN. Patients (N = 106) with oxaliplatin-induced painful CIPN were randomised to receive duloxetine or placebo. Eligible patients had chronic CIPN pain and an average neuropathic pain score ≥4/10. Duloxetine/placebo dose was 30 mg/day for 7 days, then 60 mg/day for 4 weeks. The Brief Pain Inventory-Short Form and the EORTC QLQ-C30 were used to assess pain and quality of life, respectively. Univariate and multiple logistic regression analyses were performed to identify demographic, physiologic and psychological predictors of duloxetine response. Higher baseline emotional functioning predicted duloxetine response (≥30% reduction in pain; OR 4.036; 95% CI 0.999-16.308; p = 0.050). Based on the results from a multiple logistic regression using patient data from both the duloxetine and placebo treatment arms, duloxetine-treated patients with high emotional functioning are more likely to experience pain reduction (p = 0.026). In patients with painful, oxaliplatin-induced CIPN, emotional functioning may also predict duloxetine response. ClinicalTrials.gov, Identifier NCT00489411.


Asunto(s)
Analgésicos/uso terapéutico , Antineoplásicos/efectos adversos , Clorhidrato de Duloxetina/uso terapéutico , Neoplasias Gastrointestinales/tratamiento farmacológico , Compuestos Organoplatinos/efectos adversos , Enfermedades del Sistema Nervioso Periférico/tratamiento farmacológico , Adulto , Anciano , Femenino , Neoplasias Gastrointestinales/patología , Humanos , Modelos Logísticos , Masculino , Persona de Mediana Edad , Análisis Multivariante , Estadificación de Neoplasias , Oxaliplatino , Enfermedades del Sistema Nervioso Periférico/inducido químicamente , Enfermedades del Sistema Nervioso Periférico/psicología , Ensayos Clínicos Controlados Aleatorios como Asunto , Resultado del Tratamiento
6.
J Neurooncol ; 72(2): 195-8, 2005 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-15926002

RESUMEN

PURPOSE: To report orgasmic epilepsy as a manifestation of paraneoplastic limbic encephalitis in a patient with small cell lung cancer. CASE REPORT: A 57 years-old woman presented with 2 month history of daily spells that consisted of a sudden pleasure provoking feeling described 'like an orgasm' lasting for 30 s to 1 min. She was a heavy smoker and had noted recent weight loss. Bronchial biopsy, following the finding of a right lung mass, confirmed the diagnosis of small cell lung cancer (SCLC). Spells subsided after starting carbamazepine. The lung cancer was treated with chemotherapy and chest radiation therapy resulting in a complete radiologic response. RESULTS: Brain magnetic resonance imaging (MRI) revealed left temporal lobe area of increased signal on T2 and FLAIR sequence. T1-weighted images after contrast administration demonstrated a circumscribed area of enhancement in the left anterior medial temporal lobe. Electroencephalogram (EEG) showed focal left mid-temporal sharp waves and intermittent slowing. Anti-Hu antibodies were detected in her serum supporting a diagnosis of paraneoplastic limbic encephalitis as the cause of her orgasmic epilepsy. The patient has been followed for 2 years after treatment without tumor recurrence or neurological deterioration. CONCLUSION: Orgasmic epilepsy is another mode of presentation of paraneoplastic limbic encephalitis leading to the diagnosis of an occult SCLC. EEG and MRI findings suggest that in this case the seizures originated from the left hemisphere. It is possible that early recognition and treatment of the SCLC will improve the prognosis of this neurologic entity.


Asunto(s)
Carcinoma de Células Pequeñas/complicaciones , Epilepsia del Lóbulo Temporal/etiología , Encefalitis Límbica/etiología , Neoplasias Pulmonares/complicaciones , Síndromes Paraneoplásicos del Sistema Nervioso/etiología , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Carcinoma de Células Pequeñas/patología , Carcinoma de Células Pequeñas/terapia , Epilepsia del Lóbulo Temporal/patología , Epilepsia del Lóbulo Temporal/psicología , Femenino , Humanos , Encefalitis Límbica/diagnóstico , Neoplasias Pulmonares/patología , Neoplasias Pulmonares/terapia , Imagen por Resonancia Magnética , Persona de Mediana Edad , Orgasmo , Síndromes Paraneoplásicos del Sistema Nervioso/diagnóstico , Resultado del Tratamiento
7.
Neurology ; 62(2): 234-8, 2004 Jan 27.
Artículo en Inglés | MEDLINE | ID: mdl-14745059

RESUMEN

BACKGROUND: Patients with multiple sclerosis (MS) show changes in brain activation patterns during visual and motor tasks that include decreases in the typical local network for a function and increases in other brain regions. OBJECTIVE: To determine whether brain activation patterns associated with working memory are affected by MS. METHODS: Activation of working memory circuitry was examined using an fMRI n-back task in adults with mild relapsing-remitting MS (RRMS; n = 10) and demographically matched healthy controls (n = 10). RESULTS: Group differences in brain activation emerged during both low- and high-demand conditions (p < 0.001). Overall, patients showed less activation than controls in core prefrontal and parietal regions of working memory circuitry, and greater activation in other regions within and beyond typical working memory circuitry, including bilateral medial frontal, cingulate, parietal, bilateral middle temporal, and occipital regions. CONCLUSIONS: Relative to controls, patients with mild RRMS showed shifts in brain activation patterns within and beyond typical components of working memory circuitry.


Asunto(s)
Mapeo Encefálico , Corteza Cerebral/fisiopatología , Imagen por Resonancia Magnética , Memoria/fisiología , Esclerosis Múltiple Recurrente-Remitente/fisiopatología , Adulto , Humanos , Persona de Mediana Edad
8.
J Neurol Neurosurg Psychiatry ; 74(10): 1392-7, 2003 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-14570832

RESUMEN

BACKGROUND: Deep brain stimulation (DBS) offers a non-ablative alternative to thalamotomy for the surgical treatment of medically refractory tremor in multiple sclerosis. However, relatively few outcomes have been reported. OBJECTIVE: To provide a systematic review of the published cases of DBS use in multiple sclerosis and to present four additional patients. METHODS: Quantitative and qualitative review of the published reports and description of a case series from one centre. RESULTS: In the majority of reported cases (n=75), the surgical target for DBS implantation was the ventrointeromedial nucleus of the thalamus. Tremor reduction and improvement in daily functioning were achieved in most patients, with 87.7% experiencing at least some sustained improvement in tremor control postsurgery. Effects on daily functioning were less consistently assessed across studies; in papers reporting relevant data, 76.0% of patients experienced improvement in daily functioning. Adverse effects were similar to those reported for DBS in other patient populations. CONCLUSIONS: Few of the studies reviewed used highly standardised quantitative outcome measures, and follow up periods were generally one year or less. Nonetheless, the data suggest that chronic DBS often produces improved tremor control in multiple sclerosis. Complete cessation of tremor is not necessarily achieved, there are cases in which tremor control decreases over time, and frequent reprogramming appears to be necessary.


Asunto(s)
Terapia por Estimulación Eléctrica , Esclerosis Múltiple/terapia , Tálamo/fisiología , Adulto , Femenino , Humanos , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Resultado del Tratamiento
9.
Cancer Immunol Immunother ; 49(9): 493-503, 2000 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-11092616

RESUMEN

OBJECTIVE: The aim was to determine the ability of macrophage-activated killer cells (MAK cells) obtained from peripheral blood of normal volunteers to kill glioblastoma multiforme (GBM) cell lines. Another goal was to investigate whether a bispecific antibody (bsAb) MDX-447, recognizing the high-affinity Fc receptor for IgG (FcgammaRI) and epidermal growth factor receptor (EGFR), would enhance MAK cell tumoricidal activity. METHODS: Monocytes, from leukapheresis product, were isolated by countercurrent elutriation and differentiated into MAK cells by culture with granulocyte/macrophage-colony-stimulating factor, vitamin D3 and interferon gamma. Cells were checked for sterility, endotoxin and phenotypic markers. MAK cell functional activity was measured by a flow-cytometric phagocytosis assay. Target cells, a carcinoma cell line and two glioma cell lines expressing EGFR, were stained with PKH-26. MAK cells were labeled with fluorescein-conjugated anti-CD14. Combined effectors, targets and bsAb were incubated and the percentage of MAK cells with phagocytosed targets was determined by flow cytometry. CONCLUSION: We demonstrate that a large number of highly purified monocytes, isolated from peripheral blood, can be differentiated into MAK cells for use as an adjuvant for cancer treatment. After culture these cells are sterile, endotoxin-free and comprise more than 95% MAK cells. Increased amounts of CD14, CD64 and HLA-DR, which are characteristics of macrophage activation, were expressed. MAK cells were extremely phagocytic in comparison to monocytes, even in the absence of bsAb. Moreover, bsAb enhanced the tumoricidal activity of elutriated MAK cells targeted against GBM cell lines. Therefore, intracavity MAK cells armed with MDX-447 could be an effective adoptive immunotherapy for EGFR-positive GBM.


Asunto(s)
Receptores ErbB/inmunología , Glioblastoma/inmunología , Glioblastoma/metabolismo , Células Asesinas Naturales/metabolismo , Macrófagos/metabolismo , Receptores de IgG/metabolismo , Adyuvantes Inmunológicos/uso terapéutico , Anticuerpos/metabolismo , Anticuerpos Monoclonales/metabolismo , Diferenciación Celular , Células Cultivadas , Colecalciferol/farmacología , Relación Dosis-Respuesta a Droga , Receptores ErbB/biosíntesis , Citometría de Flujo , Factor Estimulante de Colonias de Granulocitos y Macrófagos/farmacología , Humanos , Inmunoterapia/métodos , Interferón gamma/farmacología , Receptores de Lipopolisacáridos/inmunología , Neoplasias Pulmonares/metabolismo , Microscopía Confocal , Monocitos/metabolismo , Fagocitosis , Fenotipo , Receptor ErbB-2/biosíntesis , Receptores de IgG/biosíntesis , Receptores de IgG/inmunología , Células Tumorales Cultivadas
10.
Neuro Oncol ; 1(4): 289-91, 1999 10.
Artículo en Inglés | MEDLINE | ID: mdl-11550321

RESUMEN

We present one adult patient with medulloblastoma who developed polysomnographically documented obstructive sleep apnea after posterior fossa surgery. The sleep apnea worsened in conjunction with clinical and imaging-confirmed neoplastic progression and clinically improved after craniospinal radiation therapy. Medulloblastoma or its surgical treatment has never before been implicated in a sleep-related breathing disorder. We discuss possible mechanisms for its occurrence and management implications.


Asunto(s)
Neoplasias Cerebelosas/complicaciones , Meduloblastoma/complicaciones , Apnea Obstructiva del Sueño/etiología , Adulto , Neoplasias Cerebelosas/radioterapia , Neoplasias Cerebelosas/cirugía , Hemorragia Cerebral/etiología , Hemorragia Cerebral/cirugía , Terapia Combinada , Fosa Craneal Posterior , Irradiación Craneana , Craneotomía , Trastornos de Deglución/etiología , Dexametasona/uso terapéutico , Drenaje , Disartria/etiología , Humanos , Masculino , Meduloblastoma/radioterapia , Meduloblastoma/cirugía , Recurrencia Local de Neoplasia/radioterapia , Respiración con Presión Positiva , Complicaciones Posoperatorias , Radioterapia Adyuvante , Apnea Obstructiva del Sueño/terapia , Traqueostomía
11.
Epilepsia ; 37(11): 1117-20, 1996 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-8917064

RESUMEN

PURPOSE: We describe a 52-year-old man with a glioblastoma multiforme who had a prolonged partial seizure immediately after undergoing a computed tomography (CT) scan of the head with intravenous contrast medium. METHODS: Earlier computed tomography (CT) had demonstrated a ring-enhancing hypodense mass. The patient was treated with a regimen of intravenous Tirapazamine and brain irradiation. After CT scan performed on the day of his second hospitalization, the patient became aphasic. EEG showed continuous high-voltage semirhythmic sharp and slow waves in the left posterior temporal and parietal regions consistent with status epilepticus (SE). Intravenous lorazepam and a loading dose of phenytoin were administered. RESULTS: On the next morning, the patient's condition had improved almost to baseline. He had no recurrent seizures. EEG at 2-month follow-up showed no epileptiform discharges. CONCLUSION: This appears to be the first reported case of contrast medium-induced status epilepticus.


Asunto(s)
Medios de Contraste/efectos adversos , Diatrizoato de Meglumina/efectos adversos , Estado Epiléptico/inducido químicamente , Tomografía Computarizada por Rayos X , Neoplasias Encefálicas/diagnóstico por imagen , Medios de Contraste/administración & dosificación , Diatrizoato de Meglumina/administración & dosificación , Electroencefalografía , Glioblastoma/diagnóstico por imagen , Humanos , Inyecciones Intravenosas , Lorazepam/uso terapéutico , Masculino , Persona de Mediana Edad , Fenitoína/uso terapéutico , Estado Epiléptico/diagnóstico , Estado Epiléptico/tratamiento farmacológico , Resultado del Tratamiento
12.
Infect Immun ; 63(11): 4290-4, 1995 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-7591060

RESUMEN

Toxoplasma gondii is a protozoan parasite that is able to penetrate human monocytes by either passive uptake during phagocytosis or active penetration. It is expected that immunoglobulin G (IgG) opsonization will target the parasite to macrophage Fc gamma receptors for phagocytic processing and subsequent degradation. Antibody-opsonized T. gondii tachyzoites were used to infect nonadherent and adherent human monocytes obtained from the peripheral blood of seronegative individuals. The infected monocytes were evaluated for the presence of intracellular parasites and the degree of parasiticidal activity. A marked difference in both the numbers of infected macrophages and numbers of parasites per 100 macrophages was observed in the nonadherent cells when compared with those of the adherent cell population. When macrophage Fc gamma receptors were down-modulated, opsonized tachyzoites retained their ability to penetrate the host cell at a rate similar to that observed for unopsonized parasites. These results suggest that antibody opsonization of T. gondii does not prevent active penetration of human monocytes by the parasite and, furthermore, has little effect on intracellular replication of the parasite.


Asunto(s)
Monocitos/parasitología , Toxoplasma/inmunología , Animales , Anticuerpos Antiprotozoarios/inmunología , Adhesión Celular , Células Cultivadas , Humanos , Inmunoglobulina G/inmunología , Macrófagos/inmunología , Ratones , Proteínas Opsoninas , Cavidad Peritoneal/parasitología , Fagocitosis
13.
Neurology ; 38(3): 348-52, 1988 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-3258062

RESUMEN

Between 1980 and 1984, of 107 patients receiving 16 mg/d of dexamethasone for spinal cord compression, three (2.8%) developed gastrointestinal (GI) perforation and two (1.9%) GI bleeding; of 226 being tapered from 100 mg/d of dexamethasone, perforation occurred in six (2.7%) and GI bleeding in eight (3.5%). Of 125 patients with GI perforations treated between 1979 and 1986, 41 (33%) were on steroids, 24 for neurologic disease. Median duration of steroid therapy was 24 days; 20 (91%) of the neurologic patients perforated within 30 days. The steroid group had more free peritoneal involvement (p less than 0.00001), but fewer signs and symptoms of peritonitis (p less than 0.000001) than the nonsteroid group. Seventeen patients were receiving steroids for cord compression; they had significantly more rectosigmoid perforations (p less than 0.014) and associated constipation (p less than 0.000001) than the 108 remaining patients. GI perforation is a less well-recognized complication of steroid therapy in neurologic patients than is GI bleeding though it occurs as frequently, is more difficult to diagnose, and far more serious. In steroid-treated patients, prevention of constipation might avert this serious complication, while early diagnosis will improve the outcome.


Asunto(s)
Dexametasona/efectos adversos , Enfermedades Gastrointestinales/inducido químicamente , Perforación Intestinal/inducido químicamente , Adolescente , Adulto , Anciano , Niño , Preescolar , Femenino , Hemorragia Gastrointestinal/inducido químicamente , Humanos , Perforación Intestinal/patología , Masculino , Persona de Mediana Edad , Peritonitis/etiología , Factores de Riesgo , Compresión de la Médula Espinal/tratamiento farmacológico , Compresión de la Médula Espinal/etiología , Neoplasias de la Médula Espinal/complicaciones , Neoplasias de la Médula Espinal/secundario
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA