Eosinophilic panniculitis triggered by arthropod bites in chronic lymphocytic leukemia.

Skin findings are common among patients with hematological malignancies and are thought to be expressions of a reactive spectrum peculiar to immunosuppressed patients with an unclear pathogenesis. Eosinophilic panniculitis is a reaction pattern defined by single or multiple lesions consisting in nodules and plaques, and sometimes in papules and pustules, characteristically associated to hematological neoplasms or to a series of benign conditions such as arthropod bites. We report a case of eosinophilic panniculitis occurring in a 77-year-old woman with chronic lymphocytic leukemia. Our case is remarkable as the histology of panniculitis was associated with a clinical evidence of dermal papules and a history of insect bites.

Late-onset non-familial acrokeratosis verruciformis of Hopf: a case report.

Acrokeratosis verruciformis of Hopf is a rare heritable autosomal dominant genodermatosis and keratinization disorder, first described in 1931 by Hopf. It presents with multiple flat skin colored papules, mainly localized at the dorsal region of the hands and feet. AKV is an allelic disorder, associated with heterozygous missense mutation in ATP2A2 gene, which is involved in Darier's disease. Usually, it arises in early life but rare sporadic cases with adult onset have been reported. We report a case of late-onset non-familial AKV in a 52-year old patient.

Omalizumab therapy in a patient with cronic spontaneous urticaria, ulcerative colitis, hypereosinophilia and prurigo Besnier: a case report.

The case of a woman who suffered from CSU and prurigo Besnier, with a history of chronic hyper-eosinophilia, ulcerative colitis and thyroiditis, unresponsive to anti-histamines and steroids is reported. The patient received omalizumab treatment, and obtained resolution of urticaria along with improvement of cutaneous symptoms of prurigo.

Topical promethazine side effects: our experience and review of the literature.

Promethazine hydrochloride is a first-generation H1 receptor antagonist, antihistamine, and antiemetic medication that can also have strong sedative effects. The apparent ability of topical H1r/2r antagonists to target epidermal H1/2r was translated into increased efficacy in the treatment of inflammatory dermatoses, likely due to decreased inflammation and enhanced barrier function.

A case of sensitization to alitretinoin.

Alitretinoin is a unique retinoid authorised for the treatment of adults with severe chronic hand eczema (CHE) refractory to potent topical steroids. The most common adverse events (AEs) were typical class effects of oral retinoids including headache, flushing and skin disorders. To our knowledge, there are no cases of sensitization to alitretinoin reported in literature. We present a case of sensitization to alitretinoin.

Allergic diseases and climate changes: our experience and an update.

AIMS: Recent research has shown that there are many effects of climate change on aeroallergens and thus allergic diseases in humans. It is not easy to evaluate the impact of climate change and air pollution on the prevalence of allergic diseases. The present study is devoted to decipher the possible relationships between climatic changes and allergic diseases, and in particular with atopic dermatitis (AD). MATERIALS AND METHODS: To evaluate the aeroallergens effects on AD, we submitted to an allergological study protocol 59 children patients with AD to study the interaction between aeroallergens-atopy patch test (APT) and skin prick test (SPT). The same tests were performed on to the same patients after 24 months to assess the time trend. RESULTS: We found a high prevalence of house dust mites and grasses pollen APT positivity in AD's and in respiratory patients and we also found an increase in positive results in the same patients after 24 months. However, we observed a variation in the control group, in which in earlier tests all patients had negative results but after 24 months we found some positivity. CONCLUSION: We found a correlation between APT and SPT in AD and we observed a concordance between APT results and the atopy score index, underlying the triggering role of these aereoallergens in the atopic patient's skin reactivity.

Systemic contact dermatitis (SCD) due to dietary nickel.

Systemic contact dermatitis (SCD) can be caused by nickel in sensitized subjects. Nickel allergy is commonly characterized by localized reactions ensuring cutaneous exposure to this element. Systemic reactions can occur after dietary nickel ingestion. We report a case of a woman with Systemic Contact Dermatitis due to nickel.

An atypical cutaneous reaction to rivastigmine transdermal patch.

Rivastigmine is a cholinesterase inhibitor which improves cognitive function and is currently being used in patients with mild to moderate Parkinson's and Alzheimer's dementia. This drug can be given orally or topically, as transdermal patch. The latter form is currently used for most excellent compliance and few side effects. The most common cutaneous side effects are irritative dermatitis. We report the second case of active sensitization by the rivastigmine-patch in a patient suffering from Alzheimer's dementia.

Tuberculosis en el paciente VIH+: revisión de la clínica, diagnóstico y tratamiento en la era Haart / Tuberculosis in HIV+ patients: clinical, diagnostic and treatment revision in the Haart era

El VIH ha sido uno de los factores más importantes para el resurgimiento de la tuberculosis en todo el mundo en los años 80 y 90. La progresiva afectación del sistema inmunitario provocado por el VIH aumenta varias veces el riesgo de desarrollar una tuberculosis con coinfectados. Además el VIH altera la patogénesis de la tuberculosis cursando con formas extrapulmonares y patrones radiológicos atípicos que plantean presentaciones clínicas diferentes de las habituales (sobre todo en los casos de inmunodepresión severa). A partir de 1997 con la introducción de los nuevos antirretrovirales y la generalización de la triple terapia se ha modificado la historia natural de la enfermedad con un importante descenso de la mortalidad y de las infecciones oportunistas. El tratamiento y control de los pacientes VIH+ que presentan una tuberculosis es complejo debido a las interacciones medicamentosas entre las rifamicinas y algunos antirretrovirales. En este artículo vamos a revisar los últimos datos sobre el tratamiento de la infección tuberculosa latente y la enfermedad tuberculosa en el VIH y cuales son las pautas reconmendadas dependiendo de los distintos tratamientos antirretrovirales que nos podemos encontrar en la práctica clínica (AU)