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1.
J Virol Methods ; 151(1): 15-23, 2008 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-18499275

RESUMEN

The widespread perception of the effectiveness of applying tests based on the detection of antibodies against foot-and-mouth disease (FMD) viral non-capsid proteins (NCPs) to assess virus circulation irrespective of vaccination triggered the demand for international standards to evaluate the comparative performance of the upcoming assays against the OIE Index test developed at the Pan American Foot-and-Mouth Disease Center, PAHO/WHO. To this end, a panel was developed composed of 34 cattle sera from animals with an unambiguous exposed/infected status, covering serotypes O, A and C, obtained either under experimental conditions or from the field in regions with different epidemiological situations. Reference values in the Index test and their reproducibility in other laboratories, data on stability as well as results in four other commercial kits and one in house test were obtained. The characteristics of the panel which comprise adequate preparation following international guidelines, a broad range of antibody reactivity, proper stability and the ability to assess comparative diagnostic sensitivity, make it suitable as a reference standard to evaluate if tests equivalent to the OIE Index method are used in support of FMD control programs and by trading partners, and also whether they maintain their standards of diagnostic performance.


Asunto(s)
Anticuerpos Antivirales/sangre , Enfermedades de los Bovinos/inmunología , Virus de la Fiebre Aftosa/inmunología , Fiebre Aftosa/inmunología , Inmunoensayo/normas , Inmunoensayo/veterinaria , Proteínas no Estructurales Virales/inmunología , Animales , Bovinos , Enfermedades de los Bovinos/diagnóstico , Enfermedades de los Bovinos/virología , Fiebre Aftosa/diagnóstico , Fiebre Aftosa/virología , Virus de la Fiebre Aftosa/clasificación , Juego de Reactivos para Diagnóstico , Estándares de Referencia , Reproducibilidad de los Resultados , Vacunación
2.
Rev Sci Tech ; 25(1): 321-7, 2006 Apr.
Artículo en Español | MEDLINE | ID: mdl-16796057

RESUMEN

The threat of using biological material for ago-bioterrorist ends has risen in recent years, which means that research and diagnostic laboratories, biological agent banks and other institutions authorised to carry out scientific activities have had to implement biosafety and biosecurity measures to counter the threat, while carrying out activities to help prevent and monitor the accidental or intentional introduction of exotic animal diseases. This article briefly sets outthe basic components of biosafety and biosecurity, as well as recommendations on organisational strategies to consider in laboratories that support agro-bioterrorist surveillance and prevention programs.


Asunto(s)
Bioterrorismo/prevención & control , Laboratorios/normas , Seguridad/normas , Medidas de Seguridad/normas , Manejo de Especímenes/normas , Animales , Guerra Biológica/prevención & control , Planificación en Desastres , Urgencias Médicas , Humanos , Medición de Riesgo
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