The effectiveness of the comprehensive coping strategy program on clinical outcomes in breast cancer autologous bone marrow transplantation.

Patients with breast cancer who undergo autologous bone marrow/peripheral blood stem cell transplantation (ABMT) cope not only with a life-threatening medical treatment, but also with multiple, interrelated symptoms including pain, fatigue, psychological distress, and nausea. The purpose of this study was to determine, in a randomized controlled clinical trial, whether a comprehensive coping strategy program (CCSP) was effective in significantly reducing pain, fatigue, psychological distress, and nausea in patients with breast cancer who underwent ABMT. The CCSP was composed of preparatory information, cognitive restructuring, and relaxation with guided imagery. Randomization placed 52 patients in the CCSP treatment group and 58 patients in the control group. The CCSP was found to be effective in significantly reducing nausea as well as nausea combined with fatigue 7 days after the ABMT when the side effects of treatment were most severe. These results are important given the high incidence of nausea and fatigue in the ABMT population. The CCSP-treated group experienced mild anxiety as compared with the control group who reported moderate anxiety. The greatest effectiveness of CCSP may correspond to the time of the greatest morbidity for patients with breast cancer who have undergone ABM.

Pain, psychological distress, health status, and coping in patients with breast cancer scheduled for autotransplantation.

PURPOSE/OBJECTIVES: To describe pain, psychological distress, health status, and coping that patients with breast cancer who were scheduled for autotransplantation experienced; the strength and direction of relationships among pain, psychological distress, health status, and coping; and the percentage of variance within the concept of health status that age, pain, psychological distress, and coping. DESIGN: Descriptive, correlational. SETTING: An urban, National Cancer Institute-designated comprehensive cancer center located in the eastern United States. SAMPLE: A convenience sample of 83 female patients with breast cancer scheduled for autotransplantation. The population age ranged from 22-59 years (X = 44.47 years) and was comprised of 72 (88%) Caucasians, 6 (7%) African Americans, and 4 (5%) from other minorities. METHODS: An oncology clinical nurse specialist in the outpatient medical oncology clinic collected the data during a regularly scheduled visit approximately 20 days prehospitalization for high-dose chemotherapy and autotransplantation. Data were collected using a demographic data from and self-report instruments (Gaston-Johansson Painometer, State-Trait Anxiety Inventory, Beck Depression Inventory, Medical Outcomes Study Short-Form General Health Survey, and Coping Strategies Questionnaire). MAIN RESEARCH VARIABLES: Pain, psychological distress, health status, and coping. FINDINGS: Although the subjects experienced low pain intensity, the range of reported pain intensity ratings was wide. Pain locations varied but were reported mainly in the vagina, chest, shoulder, and arm. Although subjects reported primarily mild depression and mild state anxiety, the range of depression and state anxiety scores was wide. Coping strategies used most frequently to deal with pain included positive coping statements, diverting attention, praying and hoping, increasing activity level, and ability to control and decrease pain. Subjects reported moderate total health status and low role functioning. Moderate, positive correlations were seen between state anxiety and depression and physical functioning and role functioning. Sixty-five percent of the variance in health status was explained by sensory pain depression, and catastrophizing. CONCLUSIONS: Patients with breast cancer who are scheduled for autotransplantation may experience pain, psychological distress, and alterations in coping and perceived health status. Total pain intensity, sensory pain, depression, and catastrophizing appear to be important variables related to the patient's perceived health status. IMPLICATIONS FOR NURSING PRACTICE: Oncology nurses need to include assessment of pain, psychological distress, health status, and coping in their routine patient assessment prior to autotransplantation to provide appropriate care and make necessary multidisciplinary referrals. Future nursing research should be directed toward the implementation and evaluation of interventions that promote the use of comprehensive coping strategies to decrease pain, anxiety, and depression.

Caring for patients who experience chemotherapy-induced side effects: the meaning for oncology nurses.

PURPOSE/OBJECTIVES: To explore the meaning for oncology nurses of caring for patients with cancer who experience chemotherapy-induced side effects. DESIGN: Descriptive phenomenology. SETTING: Participant's work setting (n = 2), home setting (n = 1), and social setting (n = 2). SAMPLE: Five female oncology nurses (four Caucasian and one African American), age range 31-62 years, with an average of 13.3 years in oncology nursing from a variety of settings (e.g., private medical practice, ambulatory infusion centers, university-based bone marrow/peripheral blood stem cell transplantation unit) with present or recent experience administering chemotherapy. METHODS: Open-ended, audiotaped interviews were conducted. The text was transcribed verbatim and was analyzed using Colaizzi's phenomenologic analysis technique. MAIN RESEARCH VARIABLE: Meaning for oncology nurses of providing care to patients with cancer experiencing chemotherapy-induced side effects. FINDINGS: Six main themes and four subthemes emerged from the data analysis. The main themes were Being Drawn Into Patients' Experiences of Suffering. Being Challenged by Personal and Professional Imperatives to Act, Defining Treatment Purpose for Self and Patient, Reconsidering the Meaning of "Sick" and "Well," Being Changed by Ties of Shared Experience, and Advocacy for Self and Patient. CONCLUSIONS: The fundamental meaning to oncology nurses of providing care to patients with cancer experiencing chemotherapy-induced side effects is their empathetic use of self as an oncology nurse/friend to alleviate the suffering related to these side effects. IMPLICATIONS FOR NURSING PRACTICE: Providing nursing care to patients who experience chemotherapy-induced side effects is both rewarding and stressful. Sharing these research results may help other oncology nurses discover and experience deeper meaning in their own practice.

Fatigue, pain, and depression in pre-autotransplant breast cancer patients.

OBJECTIVES: The purpose of this study was to determine the influence of fatigue, pain, and depression on health status in breast cancer patients who had completed adjuvant chemotherapy and were scheduled for autologous bone marrow/peripheral blood stem cell transplant (AT). MATERIALS AND METHODS: A predictive, correlational design was used. A convenience sample of 127 women with stages II, III, and IV breast cancer was recruited. The setting was an urban National Cancer Institute-designated comprehensive cancer center located in the Eastern United States. Standardized questionnaires and the Gaston-Johansson Painometer (POM) were used to measure the variables. The subjects completed questionnaires in the outpatient clinic. Relationships between the multiple dimensions of fatigue and pain, depression, and health status were examined. Hierarchical regression techniques were used to determine the variance in health status accounted for by fatigue, pain, and depression. RESULTS: The subjects were age 22 to 60 years (Mean = 45; SD = 7.6), and primarily were married, white, Protestant, college educated, employed in a professional position, and had an average yearly household income of equal to or greater than $50,000. All subjects had previously received surgery and chemotherapy. Ninety-one percent of the participants reported fatigue as measured by the Fatigue Visual Analogue Scale. Forty-seven percent of the participants reported pain as measured by the Gaston-Johansson POM visual analogue scale. Fifty-four percent of the participants reported depression, ranging from mild to severe/high. Subjects reported a mean total perceived health status rating of 50.73 (SD 10.79). Fatigue, pain, and depression were all significantly correlated to each other and to total health status. Depression (P < .001) and pain (P < .01) significantly accounted for 64% (adjusted R2 = .60) of the variance in total health status. Fatigue (P < .05) and depression (P < .001) accounted for 42% (adjusted R2 = .36) of the variance in the perception of health status. CONCLUSIONS: Women with breast cancer previously treated with chemotherapy and awaiting AT may experience fatigue, pain, depression, and alterations in health status. Pain and depression had a significant impact on a woman's total health status, whereas depression and fatigue had an influence on perceived health status. Of the different dimensions of health status, one's perceptions of health status had the strongest correlation to total health status (r = .84, P < .001). Healthcare professionals need to be aware of the effects of multiple symptoms on health status and to provide appropriate care to alleviate them.

The importance of nursing research design and methods in cancer pain management. Enhancing care.

Cancer is diagnosed currently in more than 1 million Americans every year and cancer pain is experienced by patients in all stages of the disease. Even though research indicates that optimal pharmacologic management alone can provide adequate relief for 70% to 90% of these patients, and additional relief can be obtained from nonpharmacologic interventions, the problem of pain continues to exist. This article focuses on the contributions of nurse scientists to the study of cancer pain during the last 5 years. Selected contributions of nursing research designs and methods to the understanding of pain caused by cancer and cancer treatment modalities are reviewed. Limitations of present methodologic approaches to the study of cancer pain and gaps in nursing knowledge are examined. Recommendations for future nursing research designs and methods used to study nursing management of cancer pain and the implications of projected future treatment modalities also are discussed.