Wearable, Fiber-less, Multi-Channel System for Continuous Wave Functional Near Infrared Spectroscopy Based on Silicon Photomultipliers Detectors and Lock-In Amplification.

Development and in-vivo validation of a Continuous Wave (CW) functional Near Infrared Spectroscopy (fNIRS) system is presented. The system is wearable, fiber-less, multi-channel (16×16, 256 channels) and expandable and it relies on silicon photomultipliers (SiPMs) for light detection. SiPMs are inexpensive, low voltage and resilient semiconductor light detectors, whose performances are analogous to photomultiplier tubes (PMTs). The advantage of SiPMs with respect to PMTs is that they allow direct contact with the scalp and avoidance of optical fibers. In fact, the coupling of SiPMs and light emitting diodes (LEDs) allows the transfer of the analog signals to and from the scalp through thin electric cables that greatly increase the system flexibility. Moreover, the optical probes, mechanically resembling electroencephalographic electrodes, are robust against motion artifacts. In order to increase the signal-to-noise-ratio (SNR) of the fNIRS acquisition and to decrease ambient noise contamination, a digital lock-in technique was implemented through LEDs modulation and SiPMs signal processing chain. In-vivo validation proved the system capabilities of detecting functional brain activity in the sensorimotor cortices. When compared to other state-of-the-art wearable fNIRS systems, the single photon sensitivity and dynamic range of SiPMs can exploit the long and variable interoptode distances needed for estimation of brain functional hemodynamics using CW-fNIRS.

A feasibility study of a solid-state microdosimeter.

A solid-state silicon detector is a challenging device for microdosimetry, mainly because it can provide sensitive zones of the order of a micrometer. Moreover, these detectors are characterized by a high spatial and a good energy resolution. However, they may present some limitations, such as: (i) the minimum detectable energy which is limited by the electronic noise; (ii) radiation hardness; (iii) the geometry of the sensitive volume; (iv) the field-funnelling effect; (v) the non-tissue-equivalence of silicon. This work discusses a feasibility study of a microdosimeter based on a monolithic silicon telescope, consisting of a DeltaE and an E stage-detector, about 1 and 500 microm thick, respectively. Charges are collected separately in the two stage-detectors. The use of the DeltaE stage coupled with a tissue-equivalent converter was investigated as a solid-state microdosimeter. Irradiations with monoenergetic neutrons were performed at the INFN-Laboratori Nazionali di Legnaro (Italy). The field-funnelling effect appears to be negligible from the comparison of the experimental data with the results of Monte Carlo simulations, performed with the FLUKA code. The preliminary results of an analytical approach for the correction for geometrical effects and tissue-equivalence are also presented.