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COVID-19 , Coinfección , Encefalitis por Herpes Simple , Humanos , COVID-19/complicaciones , EncéfaloRESUMEN
OBJECTIVE: Primary headache disorders in children are one of the most prominent topics in the pediatric neurology literature. However, there are many unsolved aspects, including the conditions associated with migraine. The present study aims to report on the frequency of behavioral comorbidities in the setting of primary headache in childhood. PATIENTS AND METHODS: In this study, we enlisted 475 children (290 males and 185 females; ratio 1.6:1), aged 4 to 14 years, who were affected by primary headache. In direct interviews, children and parents gave information on the association of their headache with, attention-deficit/hyperactivity disorder, learning disabilities, tics, anxiety, depression, and obsessive-compulsive disorder. Other 475 children with no history of headache or recognized neurological conditions were matched for age, sex, race, and socioeconomic status and were used as controls. RESULTS: A significant association of primary headache was found with anxiety and depression (p-value <0.001); overall, behavioral disorders were more common in children who experienced headache than in controls (p-value <0.001). CONCLUSIONS: Primary headache in children is not associated with most of the common behavioral conditions. On the contrary, there was a significant association with anxiety and depression, as reported in adults.
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Trastornos de Ansiedad/complicaciones , Depresión/complicaciones , Cefalea/complicaciones , Adolescente , Estudios de Casos y Controles , Niño , Preescolar , Femenino , Humanos , Italia , Masculino , Clase SocialRESUMEN
OBJECTIVE: PANDAS are known as the spectrum of autoimmune pathologies related to a previous or current infection by group A beta-hemolytic streptococcus (SBEGA), dealing with several neuropsychiatric manifestations that mainly affect pediatric age. The main features consist of behavioral disease or movement disease characterized by acute-onset, presenting especially through infant period or adolescence. Specific manifestations, occurring during the progression of the disease, are the presence of otorhinolaryngologic symptoms (ENT) and orofacial movement disorders associated with temporomandibular joint pain. PATIENTS AND METHODS: We enrolled 130 children (5-15 years) with a clinical diagnosis of PANDAS between 2012 and 2018. Participants were assessed using ENT specific parameters, PSG to examine respiratory disorders and conventional audiological evaluation. Descriptive and comparative statistical analyses were performed with a control group of 51 healthy patients. RESULTS: The prevalence of ENT symptoms associated was significantly detected in 88 patients of 130 in Group A (relative frequency (%) 67.6; p=0.041) and in 51 patients of 130 in the control Group B (relative frequency (%) 39.2; p=0.063). In relation to prevalence of SDB, 54 subjects have presented nocturnal respiratory obstructive symptoms from mild to severe (relative frequency (%) 61.3; p=0.033) vs. 20 patients of Group B (relative frequency (%) 39.2; p=0.055). The obstructive severity average type was correlated to the consensual adenotonsillar development (size 3-4), (relative frequency (%) 45.4; p=0.047). The audiological deficits found were mostly of transmissive type with OME correlated and linked to the presence of occasional episodes of AOM. The four PANDAS patients who presented orobuccal dystonia (relative frequency (%) 4.54; p=0.091) achieved an improvement of the algic symptoms through the exercises of self-rehabilitation. CONCLUSIONS: Findings from our study show that respiratory diseases, characterizing a group of patients with pandas, are the direct consequences of the malformed or hypertrophic condition and suggesting in these conditions surgical therapy as an approaching tool.
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Enfermedades Autoinmunes/complicaciones , Enfermedades Autoinmunes/rehabilitación , Discinesias/fisiopatología , Trastornos del Movimiento/etiología , Trastorno Obsesivo Compulsivo/complicaciones , Trastorno Obsesivo Compulsivo/rehabilitación , Infecciones Estreptocócicas/microbiología , Adolescente , Enfermedades Autoinmunes/diagnóstico , Estudios de Casos y Controles , Niño , Preescolar , Femenino , Humanos , Enfermedades Pulmonares Obstructivas/epidemiología , Enfermedades Pulmonares Obstructivas/fisiopatología , Masculino , Trastornos del Movimiento/diagnóstico , Trastorno Obsesivo Compulsivo/epidemiología , Enfermedades Otorrinolaringológicas/epidemiología , Enfermedades Otorrinolaringológicas/fisiopatología , Dolor/etiología , Prevalencia , Índice de Severidad de la Enfermedad , Infecciones Estreptocócicas/complicaciones , Infecciones Estreptocócicas/rehabilitación , Streptococcus pyogenes/aislamiento & purificación , Articulación Temporomandibular/patologíaRESUMEN
Blepharoptosis (ptosis) is a common but often overlooked sign that may serve as a sign/manifestation of other conditions, ranging from a mild and purely cosmetic presentation to a severe and occasionally progressive disorder. Ptosis may show an acute onset or may manifest as a chronic disorder. Its presentation may vary: unilateral versus bilateral, progressive versus non-progressive, isolated versus complex which occurs in association with other symptoms, and congenital versus acquired (often concomitant with neuromuscular disorders).Congenital ptosis includes the isolated type-the congenital cranial dysinnervation disorders, which are further, distinguished into different subtypes such as Horner syndrome (HS), and ptosis as a sign/manifestation of various congenital malformation syndromes.In this article, we review the primary causes of ptosis occurring in childhood, and its various clinical presentations, including a short report on selected cases observed in our institution: a classical isolated familial ptosis comprising 14 members over 5 generations, 3 sibling with isolated congenital ptosis who in addition suffered by episodes of febrile seizures, a patient with Duane retraction syndrome who presented congenital skin and hair anomalies, and a girl with HS who showed a history of congenital imperforate hymen. A flowchart outlining the congenital and acquired type of ptosis and the clinical approach to the management and treatment of children with this anomaly is reported.
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Blefaroptosis/diagnóstico , Blefaroptosis/etiología , Blefaroptosis/terapia , Niño , Preescolar , Diagnóstico Diferencial , Femenino , Humanos , MasculinoRESUMEN
Idiopathic intracranial hypertension (IIH) is a disorder of unknown origin, which is characterized by elevated intracranial pressure (ICP) without underlying etiological evidence of neurological disease. The purpose of the current study was to evaluate epidemiological features, clinical presentation, diagnostic findings and treatment of sixteen children (7 males and 9 females) with IIH. Medical records of the patients were obtained from the University Paediatric Hospital of Catania, Italy. Clinical features, investigations and treatment approaches were retrieved. The mean age of the sixteen children at onset of symptoms was 9 years (range: 4 to 16 years). Most of the patients were classified as pre-pubertal. Mean BMI was 28.9 kg/m2. In 93.75% of patients headache was the presenting clinical symptom; and in the same percentage papilledema was detected as the accompanied sign during diagnostic flow-chart. The mean lumbar puncture opening pressure (LPOP) was 350 mm H2O. Fifty percent of the cases had normal brain imaging, while 12.5% showed enlarged optic nerve diameter and one patient had an intraocular protrusion of the optic nerve on MRI. Two patients (12.5%) had venous sinus stenosis, and one case showed an abnormal spinal MRI. With regard to therapeutic approaches, 93.75% of the cases were successfully treated with Acetazolamide. None of the patients required surgical procedures, and all neuroimaging findings disappeared after receiving treatment. In the present study we investigated the association of IIH with venous sinus stenosis. We also found ocular ultrasound to be a useful non-invasive alternative method for determining papilledema in paediatric IIH, specifically in an emergency.
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Constricción Patológica/diagnóstico por imagen , Cefalea/diagnóstico por imagen , Hipertensión Intracraneal/diagnóstico por imagen , Papiledema/diagnóstico por imagen , Acetazolamida/uso terapéutico , Adolescente , Anticonvulsivantes/uso terapéutico , Niño , Preescolar , Constricción Patológica/tratamiento farmacológico , Constricción Patológica/epidemiología , Constricción Patológica/patología , Senos Craneales/diagnóstico por imagen , Senos Craneales/efectos de los fármacos , Senos Craneales/patología , Femenino , Cefalea/tratamiento farmacológico , Cefalea/epidemiología , Cefalea/patología , Humanos , Hipertensión Intracraneal/tratamiento farmacológico , Hipertensión Intracraneal/epidemiología , Hipertensión Intracraneal/patología , Imagen por Resonancia Magnética , Masculino , Neuroimagen , Nervio Óptico/diagnóstico por imagen , Nervio Óptico/efectos de los fármacos , Nervio Óptico/patología , Papiledema/tratamiento farmacológico , Papiledema/epidemiología , Papiledema/patología , Estudios Retrospectivos , Punción Espinal , Resultado del TratamientoRESUMEN
PURPOSE: The effect of the movement near the MRI scanner bore for people with a pacemaker (PM) or an implantable cardioverter defibrillator (ICD) is experimentally evaluated and discussed. METHODS: The authors performed in vitro measurements on a saline-filled human-shaped phantom (male, 170 cm height), equipped first with an MR-conditional PM (bicameral configuration, DDD programming), then with an MR-conditional ICD (biventricular configuration, detection algorithms enable but shock delivery disable). Both the devices were able to transmit in real-time the detected cardiac activity (electrograms) while moving the phantom around the MRI scanner. The phantom was also equipped with an accelerometer and a magnetic field probe to measure the angular velocity and the magnetic field variation during the experiment. Unipolar versus bipolar sensing mode and maximum sensitivity versus nominal settings were tested. RESULTS: The sensing functions of the PM and ICD systems began to react to motion induced electromagnetic interference starting at an angular velocity as low as 2 rad/s (|dB/dT| = 2 T/s). The motion induced EMI in PM and ICD systems was interpreted as sensed intrinsic heartbeats which resulted in inappropriate pacing inhibition and arrhythmia classification. At the maximum speed of about 6 rad/s (|dB/dT| = 3 T/s), the induced EMI affected classification of ectopic beats and two episodes of VF were inappropriately recorded. CONCLUSIONS: These results demonstrate that motion in and around an MR scanner can induce EMI significant enough to be misinterpreted by implanted PMs and ICDs leading to inappropriate changes in therapy. These findings highlight that PM or ICDs, including MR-conditional systems should not enter the MRI room, except in case of an examination under specified conditions.
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Artefactos , Desfibriladores Implantables , Imagen por Resonancia Magnética/instrumentación , Movimiento , Marcapaso Artificial , Humanos , Masculino , Fantasmas de ImagenRESUMEN
Headache can represent different disorders with different etiologies; including cardiac, cerebral, vascular, psychiatric, metabolic, neurologic diseases. Recent studies have highlighted that obesity is significantly associated with headache and disability in adults. This rule also applies to children. This review focuses on literature data studying any eventual relationship between headache, migraine and obesity [shown in Body Mass Index (BMI)] in children. Research data have highlighted that there is a relationship between headache physiopathology and central and peripheral mechanisms responsible for food assumption. In this regard, neurotransmitters such as serotonin, and peptides such as orexin and adipocytokines (adiponectin and leptin) seem to play a key role both in food assumption and in headache pathogenesis. These data further emphasize the potential association between headache and BMI. Therefore, those therapeutic strategies aiming to decrease BMI may represent a model of useful treatment to understand whether weight loss reduces the incidence and the severity of headache in obese children. In conclusion, considering the effects of obesity and weight loss on the natural history of headache, important changes are expected in therapeutic management of paediatric headaches.
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Cefalea/etiología , Trastornos Migrañosos/etiología , Obesidad/complicaciones , Índice de Masa Corporal , Humanos , Trastornos Migrañosos/epidemiología , Obesidad/epidemiología , PrevalenciaRESUMEN
Immunoglobulin E (IgE) was discovered in 1966 and was found responsible for immune defense against helminths, type I hypersensitivity and allergic diseases. IgE mediates allergic responses by binding to Fc receptors (the high affinity Fc-epsilon receptor I and the low affinity Fc-epsilon receptor II or CD23) expressed on tissue mast cells and blood basophils. This binding leads to degranulation and release of pro-inflammatory mediators. Considering the pivotal role of IgE in allergic diseases, antibodies against IgE potentiate an array of new therapeutic strategies and in this regard omalizumab (rhuMAb-E25, Xolair) has been developed as a monoclonal biologic drug to block serum IgEs. Although the use of omalizumab has been studied vigorously in many adult populations with allergic diseases, there are few heterogenous studies on children. There are very few ongoing clinical trials with omalizumab exclusively on children, although some adult studies have concluded pediatric patients as a part of their studies. Nevertheless, in pediatric clinical trials omalizumab has been demonstrated to be effective and safe also in this age group. Herein, the authors present a systematic review of extensive literature data on the use of omalizumab in children and adolescents.
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Antialérgicos/uso terapéutico , Omalizumab/uso terapéutico , Antialérgicos/efectos adversos , Asma/tratamiento farmacológico , Niño , Ensayos Clínicos como Asunto , Dermatitis Atópica/tratamiento farmacológico , Hipersensibilidad a los Alimentos/tratamiento farmacológico , Humanos , Omalizumab/efectos adversos , Urticaria/tratamiento farmacológicoRESUMEN
The latest research data emphasize the interaction between the nervous and the immune systems. It has been demonstrated that the central nervous system (CNS) can be involved secondarily due to blood brain barrier (BBB) disruption via pro-inflammatory cytokines released in allergy. More recently it was demonstrated that the parasympathetic nervous system (PNS) could also be equally involved in models of peripheral inflammation such as food allergy; although this last clinical presentation has rarely been described. Herein, the authors report the case of a five-year-old Caucasian female who was admitted to our Pediatric Acute and Emergency Operative Unit for cyclic vomiting. Her vomiting, which was preceded by objective torque vertigo, headache and weakness, had been recurring with constant frequency every two months since she was 3 years old. After a complex diagnostic flow-chart, it was found that this spectrum of neurologic symptoms was due to a food allergy syndrome, which postulates some etiopathogenic hypotheses to explain the relationship between the two mentioned diseases.
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Enfermedades del Sistema Nervioso Autónomo/inmunología , Hipersensibilidad a los Alimentos/complicaciones , Caseínas/efectos adversos , Caseínas/inmunología , Preescolar , Femenino , Cefalea/inmunología , Humanos , Solanum lycopersicum/efectos adversos , Solanum lycopersicum/inmunología , Debilidad Muscular/inmunología , Vértigo/inmunología , Vómitos/inmunologíaRESUMEN
Congenital Muscular Dystrophies (CMDs) can be considered as a heterogeneous group of diseases characterized by marked weakness, generalized hypotonia and joint contractures. They are divided into pure and classical forms, without ocular and cerebral involvement, and complex forms, which are associated with cerebral abnormalities. Seizures have rarely been described in the pure forms while they seem to occur more frequently in complex forms. The aim of our study was to evaluate the incidence of seizure in CMD. Herein, the authors describe 16 cases of congenital muscular dystrophy (CMD) associated with different kinds of epileptic events, in order to study the pathogenic connection between the two clinical manifestations. In all described patients we reviewed the clinical, neurophysiologic, and neuroimaging data to determine any associations with epilepsy. The patients were divided into two groups: 14 cases with merosin positive CMD in one group and 2 patients with Walker Warburg syndrome (WWS) in the second group. In our study we found that in the first group, one benign myoclonic epilepsy (BME), one benign febrile convulsions had occurred. Also in one patient, the EEG revealed a moderately high voltage slow background with diffuse sharp waves reaching 300mV in amplitude with no clinical signs. In the merosin positive CMD patients, the presence of two different epileptic diseases, benign myoclonic epilepsy (BME) in one and febrile convulsion with tonic clinic seizures, may represent a new expression of merosine-positive congenital muscular disease (PCMD) in which the deficiency of an undiscovered muscular protein with a cerebral isoform may be the cause of epileptic events in this group of patients.
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Distrofias Musculares/complicaciones , Convulsiones/epidemiología , Convulsiones/etiología , Niño , Preescolar , Electroencefalografía , Femenino , Humanos , Incidencia , Lactante , Imagen por Resonancia Magnética , MasculinoRESUMEN
In the past few decades, the prevalence of allergic diseases has deeply increased, with a key role played by food allergies. Legumes seem to play a major role towards the overall increase in the scenario of food allergy, since they are an appreciated source, consumed worldwide, due to their high protein content, variable amounts of lipids and for the presence of vitamins. In literature there are numerous descriptions of adverse reactions after ingestion of uncooked and cooked legumes. Nevertheless, cases of allergic reactions induced by inhaling vapours from cooking legumes have rarely been described. Herein the authors report an update of the literature data on allergic reactions caused by legume steam inhalation, underlying the possible pathogenic mechanism of these atopic events and the knowledge of literature data in paediatric age. The importance of this review is the focus on the clinical aspects concerning legume vapour allergy, referring to literature data in childhood
No disponibl
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Humanos , Masculino , Femenino , Hipersensibilidad a los Alimentos/complicaciones , Hipersensibilidad a los Alimentos/diagnóstico , Fabaceae/clasificación , Rinitis Alérgica Estacional/diagnóstico , Anafilaxia/diagnóstico , Hipersensibilidad a los Alimentos/metabolismo , Hipersensibilidad a los Alimentos/prevención & control , Fabaceae/toxicidad , Rinitis Alérgica Estacional/complicaciones , Anafilaxia/complicacionesRESUMEN
No disponible
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Humanos , Femenino , Preescolar , Sulfito de Sodio/efectos adversos , Hipersensibilidad a las Drogas/complicaciones , Hipersensibilidad a los Alimentos/complicaciones , Aditivos Alimentarios/efectos adversos , Hipersensibilidad Inmediata/complicaciones , Dermatitis Atópica/complicacionesAsunto(s)
Anafilaxia/diagnóstico , Antibacterianos/metabolismo , Hipersensibilidad a las Drogas/diagnóstico , Hipersensibilidad a los Alimentos/diagnóstico , Conservantes de Alimentos/metabolismo , Sulfitos/metabolismo , Alérgenos/inmunología , Anafilaxia/dietoterapia , Anafilaxia/etiología , Antibacterianos/inmunología , Preescolar , Dietoterapia , Hipersensibilidad a las Drogas/terapia , Femenino , Hipersensibilidad a los Alimentos/complicaciones , Hipersensibilidad a los Alimentos/dietoterapia , Humanos , Inyecciones , Sulfitos/inmunología , Privación de TratamientoRESUMEN
In the past few decades, the prevalence of allergic diseases has deeply increased, with a key role played by food allergies. Legumes seem to play a major role towards the overall increase in the scenario of food allergy, since they are an appreciated source, consumed worldwide, due to their high protein content, variable amounts of lipids and for the presence of vitamins. In literature there are numerous descriptions of adverse reactions after ingestion of uncooked and cooked legumes. Nevertheless, cases of allergic reactions induced by inhaling vapours from cooking legumes have rarely been described. Herein the authors report an update of the literature data on allergic reactions caused by legume steam inhalation, underlying the possible pathogenic mechanism of these atopic events and the knowledge of literature data in paediatric age. The importance of this review is the focus on the clinical aspects concerning legume vapour allergy, referring to literature data in childhood.
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Culinaria , Hipersensibilidad a los Alimentos/inmunología , Vapor/efectos adversos , Alérgenos/inmunología , Animales , Niño , Reacciones Cruzadas , Fabaceae/inmunología , Humanos , InhalaciónRESUMEN
Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus (PANDAS) is a well-defined syndrome in which tics (motor and/or vocal) and/or obsessive compulsive disorders (OCD) consistently exacerbate in temporal correlation to a Group A beta-haemolytic streptococcal infection. In children with PANDAS, there is speculation about whether tonsillectomy or adenotonsillectomy might improve the neuropsychiatric course. Our objective was to examine whether such surgery impacted remission or, in patients without remission, modified clinical course of the disease, streptococcal antibody titers, neuronal antibodies or clinical severity of Obsessive-Compulsive Disorder (OCD) and/or tics. Study participants (n = 120) with positive PANDAS criteria were recruited, examined, and divided into surgical or non-surgery groups. The surgical group consisted of children with tonsillectomy or adenotonsillectomy (n=56). The remaining children were categorized as non-surgery (n=64). Clinical follow-up was made every 2 months for more than 2 years. Surgery did not affect symptomatology progression, streptococcal and neuronal antibodies, or the clinical severity of neuropsychiatric symptoms in these children. In conclusion, in our series clinical progression, antibody production, and neuropsychiatric symptom severity did not differ on the basis of surgical status. We cannot uphold surgical management as likely to impact positive remission rates, course of OCD/tics, or antibody concentrations in children with PANDAS.
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Enfermedades Autoinmunes/etiología , Trastorno Obsesivo Compulsivo/etiología , Infecciones Estreptocócicas/complicaciones , Streptococcus pyogenes , Tics/etiología , Tonsilectomía , Adenoidectomía , Niño , Femenino , Humanos , MasculinoRESUMEN
Three young patients with Bickerstaff's brainstem encephalitis (BBE) are reported. Some weeks following an upper tract infection, the children after a short period of recovery, showed acute onset of symmetric weakness of the lower limbs with difficulty in standing by and walking. The distal muscle weakness had a rapid progression with involvement of the cranial nerve, and then with severe impairment of the consciousness till to coma in one of the three children. BBE is a rare and often underdiagnosed affection in childhood. Common neuro-immune pathogenesis, overlap of clinical signs and strict correlation among BBE with Fisher syndrome and Guillain-Barrè syndrome lead to think that these affections represent an unique spectrum with different central and peripheral involvement. In these children, treatment with intravenous immunoglobulins resulted in a progressive and rapid resolution of the clinical features.
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Tronco Encefálico/patología , Encefalitis/tratamiento farmacológico , Inmunoglobulinas Intravenosas/uso terapéutico , Tronco Encefálico/efectos de los fármacos , Niño , Preescolar , Encefalitis/diagnóstico , Encefalitis/patología , Femenino , Humanos , Lactante , Masculino , Convulsiones/etiologíaRESUMEN
Moschcowitz's syndrome or thrombotic thrombocytopenic purpura is a quite rare pathology in childhood, being, as a matter of fact, more frequent among adult people. Often it is hard to distinguish from other pathologies in children both for its rare incidence and for the presence of clinical forms that are very heterogeneous and difficult to be classified. We report on a 13 year-old girl suffering from Moschcowitz's syndrome, in whom respiratory failure and pharyngeal hematoma were the first sign of the disease follone by jaundice, hematoma of the arm and limbs. The girl was treated with plasmapheresis with an improvement of her general condition. Since then we have followed up the girl for two years without any reappearance of the symptomatology. To our knowledge this is the first report of this peculiar presentation in children.
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Hematoma/etiología , Enfermedades Faríngeas/etiología , Púrpura Trombocitopénica Trombótica/complicaciones , Insuficiencia Respiratoria/etiología , Adolescente , Recuento de Células Sanguíneas , Femenino , Humanos , Plasmaféresis , Púrpura Trombocitopénica Trombótica/diagnóstico , Tomografía Computarizada por Rayos XRESUMEN
The Authors report on two children affected by Kawasaki disease (KD). The diagnosis of KD was made after exclusion of conditions with similar presentation. At admission these children (cases 1 and 2) presented fever, purulent caseous pharyngotonsillitis, and cervical bilateral lymphadenopathy, as well as an erythematous non-vesicular rash over the face and trunk, and a mild bilateral non-exudative conjunctivitis in case 1. After respectively three and two days corticosteroid therapy was started without any significant improvement of the general condition and any diminutions of the fever. Two days later in case 1 the child presented a clear otorrhea, a cutaneous non vesicular rash, and soon after all the remaining signs of Kawasaki disease, in case 2 otorrhea was found after 4 days and then the other signs of the KD. These patients were treated with intravenous immunoglobulin (2 g/kg day), with an improvement of their general condition. To our knowledge we report the first cases of otorrhea in the setting of Kawasaki disease. We cannot exclude that the presence of Kawasaki disease in the context of otorrhea in children positive for Epstein-Barr virus (EBV) is merely coincidental. Besides, recent acquisitions show that KD is due to a new virus that could cross-react with the EBV. The Authors conclude that the presence of EBV infection or similar condition in a febrile child may not exclude Kawasaki disease and a differential diagnosis has to be performed for a timely commencement of intravenous immunoglobulin therapy.
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Infecciones por Virus de Epstein-Barr/complicaciones , Síndrome Mucocutáneo Linfonodular/diagnóstico , Otitis Media con Derrame/etiología , Preescolar , Femenino , Humanos , Inmunoglobulinas Intravenosas/uso terapéutico , Síndrome Mucocutáneo Linfonodular/complicacionesRESUMEN
PURPOSE: A procedure for assessing occupational exposure due to magnetic resonance imaging (MRI) gradient magnetic fields and movement-induced effects in the static magnetic field is proposed and tested. METHODS: The procedure was based on the application of the weighted-peak method in time domain. It was tested in two 1.5 T total-body and one 3 T head-only scanner MRI facilities in Rome (Italy). Exposure due to switched gradient fields was evaluated in locations inside the magnet room where operators usually stay during particular medical procedures (e.g., cardiac examinations of anesthetized patients); MRI sequences were selected to approach as far as possible a representative worst case exposure scenario. Movement-induced effects were evaluated considering the actual movements of volunteer operators during work activity, by measuring the perceived time-varying magnetic field by a head-worn probe. The analysis of results was based on ICNIRP 1998 and 2010 guidelines, following a weighted-peak approach and including an ad hoc extension to the latter ones, needed to verify compliance in the frequency range 0-1 Hz. RESULTS: Exposures due to switched gradient fields in 1.5 T MRI scanners mostly resulted noncompliant with ICNIRP 1998 occupational reference levels, being, at the same time, always compliant with ICNIRP 2010 ones. Gradient field levels and ICNIRP indexes were significantly lower for the 3 T unit, due to its small dimensions, as that unit was a head-only scanner. Movement-induced effects resulted potentially noncompliant only in the case the operator moved the head inside the bore of a 1.5 T scanner. CONCLUSIONS: The procedure had proven to be a sound approach to exposure assessment in MRI. Its testing allowed to draw some general considerations about exposures to gradient magnetic fields and movement-induced effects.
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Campos Magnéticos , Imagen por Resonancia Magnética , Movimiento , Exposición Profesional/análisis , Humanos , Ondas de RadioRESUMEN
Guillain-Barré syndrome (GBS) is an inflammatory polyneuropathy characterized by acute onset, rapid progression, symmetric muscular weakness, pain, and paresthesias. The incidence of GBS in the pediatric age group is 0.8 cases per 100,000; 50%-70% of the cases are preceded by respiratory or gastrointestinal infectious episodes or vaccination. The etiopathogenesis of GBS has been hypothesized to involve a direct immune-mediated mechanism against the peripheral nerves. A series of 20 patients managed in the Department of Pediatrics of the University of Catania between 2003 and 2011 and evaluated according to epidemiologic, clinical, and therapeutic features is reported.