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1.
Rep Pract Oncol Radiother ; 29(1): 51-54, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-39165602

RESUMEN

Background: Invitations for grand rounds are typically used to evaluate faculty promotion in Radiation Oncology. To shed light on potential barriers to career progression, we conducted a study examining the racial and gender demographics of invited speakers and the inclusion of diversity, equity, and inclusion (DEI)-related talks among African-American radiation oncology speakers. Materials and methods: Radiation oncology programs in the US were contacted to obtain a list of speakers invited to their institution along with their topics presented between January 2021 and December 2022. Speakers were categorized demographically by race and gender; speaker demographics were determined by facial recognition and internet investigation. Non-faculty were eliminated from analysis. Talk topics were categorized as either DEI or non-DEI from the speaker's talk title. The Fisher's exact test was used for statistical analysis, with significance set at p < 0.05. Results: A total of 252 invited speakers and their associated talk topics were obtained from 51 radiation oncology programs. Of these speakers, 98 were female (38.9%) and 16 were African-American race (6.3%). The invited talk topic was DEI-related in 7% of total cases. Among speakers not of African-American race, this was 4.2% (10/236); among African-American speakers, it was 50% (8/16). This difference reached statistical significance (p < 0.0001). Conclusions: A significant proportion of invited African-American radiation oncology grand rounds/visiting professor talks are focused on the topic of diversity, equity, and inclusion (DEI), compared with less than 5% of non-African-American invited speakers. Targeted efforts to expand African-American representation in non-DEI topics are needed to ensure and expand diversity in Radiation Oncology.

2.
Biomolecules ; 12(4)2022 04 12.
Artículo en Inglés | MEDLINE | ID: mdl-35454157

RESUMEN

BACKGROUND: Preventing delayed cerebral ischemia (DCI) after subarachnoid hemorrhage (SAH) remains an important therapeutic target. Preconditioning stimulates multiple endogenous protective mechanisms and may be a suitable treatment for DCI following SAH. We here compare remote limb conditioning with resveratrol conditioning in a clinically relevant SAH model. METHODS: We produced a SAH in 39 male Sprague Dawley rats using a single injection model. Animals were randomized to four groups: repetitive limb conditioning with a blood pressure cuff, sham conditioning, intraperitoneal resveratrol (10 mg/kg) or intraperitoneal vehicle administered at 24, 48 and 72 h after SAH. On day 4 neurological and behavioral scores were obtained, and animals were euthanized. The cross-sectional area of the basilar artery was measured at the vertebrobasilar junction, and at the mid and distal segments. Hippocampal cells were counted in both hemispheres and normalized per mm length. We compared true limb preconditioning with sham conditioning and resveratrol with vehicle preconditioning. RESULTS: The cross-sectional area of the mid-basilar artery in the true limb preconditioning group was significantly larger by 43% (p = 0.03) when compared with the sham preconditioning group. No differences in the cross-sectional area were found in the resveratrol-treated group when compared to the vehicle-treated group. We found no differences in the neuro score, behavioral score, and in mean hippocampal neuron counts between the groups. CONCLUSION: We found beneficial vascular effects of remote limb preconditioning on SAH-induced basilar artery vasoconstriction. Our findings support further studies of limb preconditioning as a potential treatment after SAH.


Asunto(s)
Isquemia Encefálica , Hemorragia Subaracnoidea , Vasoespasmo Intracraneal , Animales , Femenino , Masculino , Ratas , Ratas Sprague-Dawley , Resveratrol/farmacología , Resveratrol/uso terapéutico , Roedores , Hemorragia Subaracnoidea/tratamiento farmacológico , Vasoespasmo Intracraneal/tratamiento farmacológico , Vasoespasmo Intracraneal/prevención & control
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