RESUMEN
OBJECTIVE: To estimate the benefits of iterative prevalence surveys in detecting trends of hospital-acquired infections (HAIs). METHODS: On the basis of the French protocol for national prevalence studies, HAI data of 15 consecutive annual surveys performed at the same period by the same group of investigators was gathered in a single database to describe the trend of HAIs in a University Hospital over a 15-year period. RESULTS: A total of 20,401 patients were included. Overall, the prevalence of patients presenting with at least one HAI acquired in our University Hospital was 5.1% [95% CI, 4.8-5.4%]. The prevalence of HAIs and antimicrobial drug use significantly decreased over time (P<0.01). CONCLUSION: Despite limitations, repeated prevalence surveys can be a useful tool for promoting control measures to better prevent HAIs.
Asunto(s)
Infección Hospitalaria/epidemiología , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Antibacterianos/uso terapéutico , Niño , Preescolar , Infección Hospitalaria/tratamiento farmacológico , Infección Hospitalaria/prevención & control , Estudios Transversales , Utilización de Medicamentos/tendencias , Femenino , Francia/epidemiología , Encuestas Epidemiológicas , Hospitales Universitarios , Humanos , Lactante , Masculino , Persona de Mediana Edad , Prevalencia , Factores de Tiempo , Adulto JovenRESUMEN
Two patients with no travel history and sharing the same room were colonized by the same strain of New Delhi metallo-ß-lactamase 1 (NDM-1)-producing Escherichia coli within a geographical area not endemic for this highly multidrug-resistant bacterium. It was documented an absence of an epidemiological and bacteriological link with a third patient returning from India after surgery and found to be infected by an NDM-1-producing Citrobacter strain during the same period. Despite extensive investigation, the source of contamination of the two former patients was not elucidated. This case report illustrates the need of investigating rapidly the emergence of highly multidrug-resistant Enterobacteriaceae, to stop their dissemination in a nosocomial setting.
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Infección Hospitalaria/transmisión , Infecciones por Escherichia coli/transmisión , Escherichia coli/efectos de los fármacos , Escherichia coli/enzimología , beta-Lactamasas/biosíntesis , Adolescente , Anciano de 80 o más Años , Infección Hospitalaria/microbiología , Farmacorresistencia Bacteriana Múltiple , Enfermedades Endémicas , Escherichia coli/genética , Infecciones por Escherichia coli/microbiología , Femenino , Francia/epidemiología , Humanos , MasculinoRESUMEN
UNLABELLED: The official vaccinal program is updated every year. Nevertheless, the observed vaccination coverage does not correspond to the recommended program. OBJECTIVE: Our objective was to identify factors influencing vaccinal practice, especially for hepatitis B. METHOD: We sent a questionnaire to two medical populations of the French Loire subdivision: 100 randomly chosen general practitioners, and 53 pediatricians and physicians working for public office for mother and childcare. RESULTS: The updated official recommendations were considered as the reference document for both populations. The study did not reveal any hesitation or lack of information, which could explain the low hepatitis B vaccinal coverage. Eighty-five percent of questioned physicians claimed having changed their practice, thanks to the easy use of Infanrix Hexa®, probably explaining the current improvement of hepatitis B vaccinal coverage rate.
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Pautas de la Práctica en Medicina , Vacunación/estadística & datos numéricos , Adolescente , Niño , Preescolar , Estudios Transversales , Vacuna contra Difteria, Tétanos y Tos Ferina , Vacunas contra Difteria, Tétanos y Tos Ferina Acelular , Femenino , Francia , Medicina General , Adhesión a Directriz/estadística & datos numéricos , Vacunas contra Haemophilus , Conocimientos, Actitudes y Práctica en Salud , Humanos , Lactante , Masculino , Centros de Salud Materno-Infantil , Motivación , Pediatría , Vacuna Antipolio de Virus Inactivados , Guías de Práctica Clínica como Asunto , Pautas de la Práctica en Medicina/estadística & datos numéricos , Práctica Privada , Muestreo , Encuestas y Cuestionarios , Vacunación/legislación & jurisprudencia , Vacunas CombinadasAsunto(s)
Cáusticos/química , Compuestos de Cloro/química , Corrosión , Desinfección/métodos , Óxidos/química , Polietileno/química , Compuestos de Cloro/farmacología , Desinfectantes/farmacología , Hospitales , Humanos , Legionella/efectos de los fármacos , Óxidos/farmacología , Microbiología del AguaRESUMEN
Lactobacilli rhamnosus infections are rare and occur in patients with severe conditions causing immunosuppression and/or in those who have received intense antibiotic treatment such as with teicoplanin and vancomycin. We report two cases which occurred within a period of 48 hours, during regression of pancreatitis in two women aged 35 and 70 years old, hospitalized in the same department. Several criteria pointed towards two independent infections but the rarity and chronology of the appearance of these infections raised the question of possible cross-contamination. Lactobacillus rhamnosus was isolated in intra-abdominal samples from both patients, and in blood cultures from one of them. Specimens were monomicrobial. The description of these observations shows the limits of molecular biology for identifying the Lactobacillus rhamnosus strain: it was not possible to determine whether a single clone or two different clones were involved.
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Infecciones por Bacterias Grampositivas/tratamiento farmacológico , Lacticaseibacillus rhamnosus , Pancreatitis/microbiología , Adulto , Anciano , Antidepresivos/uso terapéutico , Proteína C-Reactiva/metabolismo , Depresión/tratamiento farmacológico , Femenino , HumanosRESUMEN
PURPOSE OF THE STUDY: The aim of this study was to evaluate results of coraco-clavicular ligamentoplasty using a synthetic material, dacrylene, for the treatment of recent and neglected acromio-clavicular dislocation. MATERIAL AND METHODS: The series initially included 104 patients who underwent surgery from 1981 to 2001. Among these, 75 were reviewed with a mean follow-up of 85 months (72% review rate). A complete set of clinical (Constant score/100 points) and radiographic (coraco-clavicular distance) data was available for 39 patients. Thirty-six answered a questionnaire with measurement of a partial Constant score (65 points). RESULTS: Seventy-seven percent of patients were satisfied or very satisfied and 98% presented good or very good functional outcome as assessed by the partial Constant score. Reduction of the coraco-clavicular distance was satisfactory for 54% of patients evaluated. For the vast majority, insufficient reduction was reducible and had no impact on the functional outcome. The time to treatment (recent or neglected dislocation) had no effect on patient satisfaction or functional outcome. The coraco-clavicular distance was greater for dislocations operated on late (p<0.05). The grade of the injury, the type of assembly used, and use or not of lateral clavicular resection had no effect on clinical or radiological outcomes. Dacrylene was tolerated poorly by 14 patients (18.7%). The functional outcome was very good for all after removal of the ligament. DISCUSSION: Functional results are good with this technique which enables a well sustained stable reduction of recent and neglected dislocations, irrespective of the grade of the lesion or the type of assembly used. Reducing the mechanical stress on the ligament and prudent rehabilitation exercises should be helpful in preventing intolerance reactions.
Asunto(s)
Articulación Acromioclavicular/lesiones , Materiales Biocompatibles , Clavícula , Luxaciones Articulares/cirugía , Ligamentos Articulares/cirugía , Prótesis e Implantes , Escápula , Articulación Acromioclavicular/diagnóstico por imagen , Articulación Acromioclavicular/cirugía , Adolescente , Adulto , Materiales Biocompatibles/efectos adversos , Clavícula/diagnóstico por imagen , Estudios de Seguimiento , Fracturas Óseas/cirugía , Humanos , Cápsula Articular/lesiones , Cápsula Articular/cirugía , Ligamentos Articulares/diagnóstico por imagen , Ligamentos Articulares/lesiones , Persona de Mediana Edad , Músculo Esquelético/lesiones , Satisfacción del Paciente , Prótesis e Implantes/efectos adversos , Radiografía , Rango del Movimiento Articular/fisiología , Estudios Retrospectivos , Rotura , Escápula/diagnóstico por imagen , Anclas para Sutura , Resultado del TratamientoRESUMEN
OBJECTIVE: The authors had for aim to study the distribution of HIV-1 subtypes in a cohort of HIV-1 positive patients in the University hospital of Saint-Etienne, France, and to describe the epidemiological characteristics of patients infected with a non-B subtype strain. DESIGN: An epidemiological study was made on 271 HIV-1 positive patients followed up in the Infectious Diseases Department over 20 years. All patients sample were subtyped by serotyping and some samples were also tested by genotyping. RESULTS: Two hundred and sixty-four patients (191 men and 73 women) were found infected by an HIV-1 strain belonging to the M group. After combining serotyping and genotyping results, 195 patients were found infected by a B subtype and 69 by a non-B subtype. Most of the latter strains belonged to an A subtype or related ones. The following factors were shown to be linked to an infection by a non-B strain: being born abroad, having contracted the infection though heterosexual practice, and being a woman. The incidence of non-B strains increased regularly over time (to reach more than 40% in 2003). This progression was especially noted for men born in France with risky sexual behaviour. CONCLUSION: These results indicate that more than 40% of HIV-1 new cases detected in the Saint-Etienne area are related to non-B strains and that strains of A and related subtypes are common in the local population with risky sexual behaviour.
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Infecciones por VIH/virología , VIH-1/clasificación , Femenino , Francia , Genotipo , Humanos , Masculino , Prevalencia , SerotipificaciónRESUMEN
A retrospective study was undertaken to analyse the risk factors for systemic emboli in infective endocarditis. Patients (n = 80; 70% males; mean age 65 years; range 20-91 years) with infective endocarditis, as defined by the Duke criteria and diagnosed using transoesophageal echocardiography during the period January 1995 to March 2001, were included. The average time between the start of the illness and the beginning of antibiotic treatment was 55 days (range 0-405 days). The pathogens identified were streptococci (n = 47), staphylococci (n = 11), enterococci (n = 9), and others (n = 4). In nine cases, blood cultures were sterile. Thirty patients with at least one embolic episode were compared with 50 control patients. According to univariate analysis, the main risk factor for systemic emboli was the size of the vegetation (12.4 mm vs. 7.8 mm; p = 0.0005). The risk of emboli was 57% when the vegetation measured > 10 mm and only 22% when it was < 10 mm (p = 0.003). The mobility of the vegetation was also a risk factor: 48% if the vegetation was mobile; and 9% if fixed (p = 0.003). Sex, age, pathogen, antibiotic treatment, type of valve and the number and position of the vegetations were not found to be risk factors. With multivariate analysis, only mobility was identified as a risk factor. Overall, mobile vegetations > 10 mm in size were associated with an increased risk of embolic episodes in infective endocarditis.
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Embolia/etiología , Endocarditis Bacteriana/complicaciones , Endocarditis Bacteriana/microbiología , Adulto , Anciano , Anciano de 80 o más Años , Ecocardiografía , Infecciones por Bacterias Grampositivas/microbiología , Cocos Grampositivos/clasificación , Cocos Grampositivos/aislamiento & purificación , Cardiopatías/complicaciones , Cardiopatías/microbiología , Humanos , Embolia Intracraneal/etiología , Masculino , Persona de Mediana Edad , Embolia Pulmonar/etiología , Estudios Retrospectivos , Factores de RiesgoRESUMEN
This study describes two epidemic outbreaks involving Staphylococcus aureus with reduced sensitivity to glycopeptides, one in 2000 involving eight patients and the other in 2001-2002 involving 16 patients. These strains were detected rapidly, thanks to routine screening for the offending organisms in the bacteriology laboratory of our hospital. The clonal character of these strains was confirmed by pulsed field electrophoresis. The management of these epidemic outbreaks confirmed (i) the need for systematic adoption of standard precautions, (ii) the importance of circulating information in combating multi-resistant bacteria, as well as the difficulties in transferring colonised patients to different hospital wards, and (iii) the intermittent nature of S. aureus carriage, resulting in a need for prolonged surveillance of colonised and/or infected patients. In addition, our study underlines the value of a multi-disciplinary approach to the management of diffusion of multi-resistant bacteria.
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Antibacterianos/farmacología , Brotes de Enfermedades , Resistencia a Múltiples Medicamentos , Péptidos , Infecciones Estafilocócicas/epidemiología , Staphylococcus aureus/efectos de los fármacos , Antibacterianos/uso terapéutico , Francia/epidemiología , Humanos , Incidencia , Pruebas de Sensibilidad Microbiana , Estaciones del Año , Infecciones Estafilocócicas/tratamiento farmacológico , Staphylococcus aureus/clasificación , Staphylococcus aureus/aislamiento & purificaciónRESUMEN
We report an outbreak of infections due to methicillin-resistant Staphylococcus aureus (MRSA) in a medical unit and the possible implication of student nurses in the dissemination of the epidemic strain. A retrospective epidemiological study looking for hospitalised patients colonised or infected with MRSA from the 1st of June to the 30th of September 2001 in the unit was conducted. An audit of delivered cares and a nasal screening of health care workers (HCW) was performed. Six patients were colonised or infected with a MRSA strain, four of them exhibiting a bacteremia. Six HCW had a nasal carriage of MRSA. Typing of the MRSA strains by pulsed field gel electrophoresis demonstrated an epidemic clone isolated from five of six patients, two student nurses and one HCW not implicated in nursing cares. This report illustrates the risk of nosocomial outbreak linked to cares delivered by student nurses.
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Infección Hospitalaria/epidemiología , Resistencia a la Meticilina , Infecciones Estafilocócicas/epidemiología , Staphylococcus aureus/efectos de los fármacos , Estudiantes de Enfermería , Infección Hospitalaria/enfermería , Brotes de Enfermedades , Francia/epidemiología , Personal de Salud , Humanos , Pacientes Internos/estadística & datos numéricos , Tamizaje Masivo , Estudios Retrospectivos , Medición de Riesgo , Infecciones Estafilocócicas/enfermeríaRESUMEN
Group A rotaviruses, human caliciviruses, astroviruses, and adenovirus types 40 and 41 were detected by enzyme immunoassay or reverse transcription-PCR in 61, 14, 6, and 3% of stool specimens from 414 children consulting for gastroenteritis between 1995 and 1998. These data highlight the importance of caliciviruses in infantile gastroenteritis. Among these, Norwalk-like viruses belonging to genogroup II were predominant.