Evaluation of oxidative and antioxidative parameters in generalized anxiety disorder.

Generalized anxiety disorder (GAD) is a prevalent psychiatric disorder. The exact causes of GAD still unknown, in addition to neurochemical and neuroanatomic disorders, genetic and environmental factors are discussed in etiology. In our study we aimed to evaluate the oxidative metabolism's status and investigate the role of oxidative metabolites in GAD. Blood samples were taken from enrolled subjects in appropriate way and total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) were studied in Harran University Biochemistry Labs. Results were compared between groups. The patients' TOS and OSI levels were significantly higher than control group. The patients' TAS levels were significantly lower than controls'. According to our findings, oxidative stress mechanism might have a role in GAD pathophysiology. In the future, total antioxidants may be used as a biologic marker in GAD etiology but more research is needed.

No effect of antidepressant treatment on elevated serum ceruloplasmin level in patients with first-episode depression: a longitudinal study.

BACKGROUND AND AIMS: Ceruloplasmin, an acute phase reactant with antioxidant capacity, has been found to be increased in some psychiatric disorders like schizophrenia and obsessive compulsive disorder. However, studies in depression are very scarce. We undertook this study determine the serum ceruloplasmin levels of depressive patients before and after treatment, to compare them with those of healthy control subjects, and to assess any possible association of ceruloplasmin and treatment response. METHODS: Nineteen (8 male, 11 female) patients with major depressive disorder and 40 (17 male, 23 female) healthy control subjects were included in the study. The patients received naturalistic antidepressant treatment for 8 weeks after diagnosis. Serum ceruloplasmin levels and Hamilton Depression Rating Scale (HAM-D) scores of the patients were measured before and after their antidepressant treatment. Blood collection for ceruloplasmin measurement was done only once for healthy control subjects. RESULTS: Patients' ceruloplasmin levels before and after antidepressant treatment were significantly higher than control subjects (t = 7.569, p <0.001 and t = 6.764, p <0.001, respectively). Despite clinical improvement, ceruloplasmin did not show any significant change after treatment in patients with depression (t = -1.163, p = 0.260) and remained higher than levels of control subjects. No correlation was found between HAM-D score, presence of response, and ceruloplasmin levels. CONCLUSIONS: Compared to healthy control subjects, ceruloplasmin level seemed to be higher in patients with depression and remained high, despite acute antidepressant treatment. Improvement in clinical measurements of depression after antidepressant treatment was not reflected as significant alterations in serum ceruloplasmin levels.

[Investigation of sexual problems in married people living in the center of Konya]. / Konya Il Merkezi'nde Yasayan Evli Nüfusta Cinsel Sorunlarin Arastirilmasi.

OBJECTIVE: Sexual problems are widely encountered in community. While studies clinically performed concerning sexual problems in Turkey exist, there are no field studies related to sexual problems witnessed in both men and women. In this study, sexual problems in married population and the level of their sexual knowledge have been tried to be investigated. METHOD: The cosmos of the study consisted of the whole married population between the ages of 18 and 60 and living in the province of Konya. Sociodemografic Information Form and Golombok-Rust Inventory of Sexual Satisfaction were performed in 945 subjects accepting to take part in the study and appropriate. RESULTS: Average age rate of the males taking part in the study was 38.5+/-9.5 and the same rate of women was 34.2+/-9.8. According to the findings provided via GRISS, the rate of erectile dysfunction (ED) in men was 14.5 %, the rate of premature ejeculation (PE) 29.3 %, the rate of anorgasmia in women was found to be 5.3 %,and the rate of vaginismus to be 15.3 %. CONCLUSION: Prevalence rates of PE, ED and anorgasmia in our sample was parallel to those provided from other countries at same age group. Vaginismus rate in our study is higher compared to other studies.