The FeatureCloud Platform for Federated Learning in Biomedicine: Unified Approach.

BACKGROUND: Machine learning and artificial intelligence have shown promising results in many areas and are driven by the increasing amount of available data. However, these data are often distributed across different institutions and cannot be easily shared owing to strict privacy regulations. Federated learning (FL) allows the training of distributed machine learning models without sharing sensitive data. In addition, the implementation is time-consuming and requires advanced programming skills and complex technical infrastructures. OBJECTIVE: Various tools and frameworks have been developed to simplify the development of FL algorithms and provide the necessary technical infrastructure. Although there are many high-quality frameworks, most focus only on a single application case or method. To our knowledge, there are no generic frameworks, meaning that the existing solutions are restricted to a particular type of algorithm or application field. Furthermore, most of these frameworks provide an application programming interface that needs programming knowledge. There is no collection of ready-to-use FL algorithms that are extendable and allow users (eg, researchers) without programming knowledge to apply FL. A central FL platform for both FL algorithm developers and users does not exist. This study aimed to address this gap and make FL available to everyone by developing FeatureCloud, an all-in-one platform for FL in biomedicine and beyond. METHODS: The FeatureCloud platform consists of 3 main components: a global frontend, a global backend, and a local controller. Our platform uses a Docker to separate the local acting components of the platform from the sensitive data systems. We evaluated our platform using 4 different algorithms on 5 data sets for both accuracy and runtime. RESULTS: FeatureCloud removes the complexity of distributed systems for developers and end users by providing a comprehensive platform for executing multi-institutional FL analyses and implementing FL algorithms. Through its integrated artificial intelligence store, federated algorithms can easily be published and reused by the community. To secure sensitive raw data, FeatureCloud supports privacy-enhancing technologies to secure the shared local models and assures high standards in data privacy to comply with the strict General Data Protection Regulation. Our evaluation shows that applications developed in FeatureCloud can produce highly similar results compared with centralized approaches and scale well for an increasing number of participating sites. CONCLUSIONS: FeatureCloud provides a ready-to-use platform that integrates the development and execution of FL algorithms while reducing the complexity to a minimum and removing the hurdles of federated infrastructure. Thus, we believe that it has the potential to greatly increase the accessibility of privacy-preserving and distributed data analyses in biomedicine and beyond.

Dealing with change in process choreographies: Design and implementation of propagation algorithms.

Enabling process changes constitutes a major challenge for any process-aware information system. This not only holds for processes running within a single enterprise, but also for collaborative scenarios involving distributed and autonomous partners. In particular, if one partner adapts its private process, the change might affect the processes of the other partners as well. Accordingly, it might have to be propagated to concerned partners in a transitive way. A fundamental challenge in this context is to find ways of propagating the changes in a decentralized manner. Existing approaches are limited with respect to the change operations considered as well as their dependency on a particular process specification language. This paper presents a generic change propagation approach that is based on the Refined Process Structure Tree, i.e., the approach is independent of a specific process specification language. Further, it considers a comprehensive set of change patterns. For all these change patterns, it is shown that the provided change propagation algorithms preserve consistency and compatibility of the process choreography. Finally, a proof-of-concept prototype of a change propagation framework for process choreographies is presented. Overall, comprehensive change support in process choreographies will foster the implementation and operational support of agile collaborative process scenarios.