RESUMEN
The objective of the present study was to estimate the effectiveness of the spa and health resort-based treatment of non-alcoholic fatty liver disease in 40 patients at the mean age of 48,8 ± 5.7 years suffering from type 2 diabetes mellitus. All of them received combined therapy including the application of potable Essentuki-Novaya mineral water (20 patients) or Essentuki No 4 water (20 patients). This therapeutic modality resulted in positive dynamics of clinical symptoms of the disease, the functional liver tests, and parameters of intra-hepatic hemodynamics, lipid peroxidation homeostasis, and the hormonal status. It is concluded that the spa and health resort-based treatment with the application of local drinking Essentuki-type mineral waters for the management of non-alcoholic fatty liver disease in the patients presenting with type 2 diabetes mellitus leads to the improvement of the main functions of the liver, stabilizes carbohydrate and lipid metabolism, and prevents progression of the pathological process.
Asunto(s)
Balneología , Diabetes Mellitus Tipo 2/terapia , Aguas Minerales , Enfermedad del Hígado Graso no Alcohólico/terapia , Adulto , Femenino , Humanos , Masculino , Persona de Mediana EdadRESUMEN
A method has been developed for the correction of metabolic, hepato-biliary, and ischemic disorders in the patients with chronic nonalcoholic lesions of the liver by means of combined treatment using pharmaceutical agents (ursosan and Omega-3), Tib-2 drinking mineral water, and sinusoidal modulated currents (SMC) electrophoresis of this water in the right hypochondrial region. This therapy ensured pathogenetically sound modulation of the functional state of the liver and the biliary tract; moreover, it reduced the severity of regional ischemia, improved rheologic properties of the blood, normalized lipid metabolism and peroxidation, influenced production ofpro-inflammatory cytokines.
Asunto(s)
Hepatopatías/rehabilitación , Aguas Minerales/administración & dosificación , Adulto , Anciano , Balneología/métodos , Sistema Biliar/metabolismo , Citocinas/metabolismo , Ácidos Grasos Omega-3/administración & dosificación , Femenino , Hospitales , Humanos , Metabolismo de los Lípidos/efectos de los fármacos , Peroxidación de Lípido/efectos de los fármacos , Hígado/metabolismo , Hepatopatías/metabolismo , Masculino , Persona de Mediana EdadRESUMEN
The objective of the present work was to estimate the effectiveness of combined spa-and-resort treatment with the use of the Essentuki-type drinking mineral waters for the patients presenting with non-alcoholic fatty liver disease. A total of 40 patients presening with non-alcoholic fatty liver disease (NOFLD) were available for the examination. The study has demonstrated positive dynamics of clinical symptoms and results of liver functional tests, characteristics of intrahepatic dynamics, lipid metabolism, antioxidant hemostais, and the hormonal status of the patients with non-alcoholic fatty liver disease. The intake of the Essentuki-type drinking mineral waters promoted normalization of adiponectin and leptin levels in conjunction with the reduction in the degree of insulin resistance, i.e., the key pathogenetic factors responsible for hepatic steatosis and non-alcoholic steatohepatitis. It is concluded that the Essentuki-type drinking mineral waters may be recommended for the inclusion in the combined treatment and prevention of the progression of non-alcoholic fatty liver disease.
Asunto(s)
Balneología/métodos , Hígado Graso/terapia , Aguas Minerales/administración & dosificación , Adulto , Antioxidantes/metabolismo , Hígado Graso/sangre , Femenino , Hemostasis/efectos de los fármacos , Humanos , Resistencia a la Insulina , Metabolismo de los Lípidos/efectos de los fármacos , Masculino , Enfermedad del Hígado Graso no AlcohólicoAsunto(s)
Neoplasias Gastrointestinales/rehabilitación , Neoplasias Gastrointestinales/cirugía , Colonias de Salud , Licencia Médica , Microondas/uso terapéutico , Modalidades de Fisioterapia/normas , Adulto , Terapia Combinada , Femenino , Neoplasias Gastrointestinales/inmunología , Neoplasias Gastrointestinales/metabolismo , Humanos , Masculino , Persona de Mediana Edad , Aguas Minerales/administración & dosificación , Modalidades de Fisioterapia/legislación & jurisprudencia , Factores de TiempoAsunto(s)
Enfermedades Duodenales/terapia , Enfermedades del Esófago/terapia , Gastropatías/terapia , Úlcera/terapia , Antibacterianos/uso terapéutico , Balneología , Enfermedades Duodenales/tratamiento farmacológico , Enfermedades del Esófago/tratamiento farmacológico , Colonias de Salud , Humanos , Patentes como Asunto , Gastropatías/tratamiento farmacológico , Úlcera/tratamiento farmacológicoRESUMEN
The dynamics of leukocytes adhesion to brain microvenules endothelium of Wistar rats were studied under acute massive blood loss. Using the method of vital videomicroscope study of the influence of the influence of the blood volume reduction on the leukocyte-endothelium interaction is investigated. We studied vessels of the diameter under 30 mcm. It is shown that under progressing reduction of the system arterial pressure under 60 mm Hg, the number of leukocytes adhesion to venules' wall reached 20 +/- 3 on 100 mcm, but in terminal stage such acts are the greatest. It is supposed that as a result massive blood loss leukocytes turn out to be the direct reason of the deep pathological disturbances of microcirculation in the brain.
Asunto(s)
Encéfalo/irrigación sanguínea , Endotelio Vascular/fisiología , Leucocitos/fisiología , Animales , Adhesión Celular , Masculino , Microcirculación/patología , Ratas , Ratas Wistar , Choque Hemorrágico/patología , VénulasRESUMEN
After a deep prolonged hypothermia, fast warming up of experimental rats (0.26 degree C/min) to the body temperature 35-36 degrees C entailed recovery of the heart rate, blood pressure, 1-min blood volume, oxygen consumption in rats. However, in the process of warming up, cardiac output, function of the left ventricle, oxygen consumption and the CO2 production were decreased. Acidosis and haemoconcentration following a 3 hr prolonged hypothermia were reversible.
Asunto(s)
Hipotermia/fisiopatología , Oxígeno/metabolismo , Intercambio Gaseoso Pulmonar , Recalentamiento , Animales , Transporte Biológico , Temperatura Corporal , Hemodinámica , Hipotermia/sangre , Hipotermia/metabolismo , Inmersión , Masculino , Consumo de Oxígeno , Ratas , Ratas Wistar , Respiración Artificial , Factores de TiempoRESUMEN
After a 1 hr deep prolonged immersion hypothermia, warming up of experimental rats in water (the temperature increase 0.25 degree C/min) entailed a complete recovery of all the parameters of gas exchange, haemodynamics, external respiration, and the blood. After a 3 hr hypothermia, under the same conditions of warming up, oxygen consumption, CO2 production, and 1 min blood volume were obviously decreased, and the animals died within 0.5-1.0 hr.
Asunto(s)
Paro Cardíaco/fisiopatología , Hipotermia/fisiopatología , Consumo de Oxígeno , Oxígeno/metabolismo , Insuficiencia Respiratoria/fisiopatología , Recalentamiento , Animales , Transporte Biológico , Temperatura Corporal , Paro Cardíaco/sangre , Paro Cardíaco/etiología , Hemodinámica , Hipotermia/sangre , Hipotermia/complicaciones , Inmersión , Masculino , Intercambio Gaseoso Pulmonar , Ratas , Ratas Wistar , Respiración Artificial , Insuficiencia Respiratoria/sangre , Insuficiencia Respiratoria/etiología , Factores de TiempoRESUMEN
The data obtained show that, at the initial stages of hypothermia, a decrease in the oxygen consumption and carbon dioxide production, cardiac output, and heart rate occurred in accordance with the temperature coefficient. Suppression of the tissue gas exchange was unrelated to disorders in the lung gas exchange but determined rather by a progressing weakening of heart activity, decrease in the cardiac output, and increase in the general vascular peripheral resistance.
Asunto(s)
Apnea/fisiopatología , Hipotermia/fisiopatología , Consumo de Oxígeno/fisiología , Animales , Apnea/sangre , Apnea/complicaciones , Velocidad del Flujo Sanguíneo/fisiología , Análisis de los Gases de la Sangre , Presión Sanguínea/fisiología , Dióxido de Carbono/sangre , Hipotermia/sangre , Hipotermia/complicaciones , Masculino , Contracción Miocárdica/fisiología , Oxígeno/sangre , Ratas , Ratas Wistar , Función Ventricular Izquierda/fisiologíaRESUMEN
Artificial lung ventilation (ALV) was shown to restore the gas exchange in rats following their cooling to brain temperature 17.0-17.6 degrees C. However, the ALV proved ineffective if applied in 22.1 +/- 2.1 min after cessation of breathing. Fast warming up of the animals increased oxygen consumption and carbon dioxide production, and caused a less obvious metabolic acidosis in the rats in the course of recovering from hypothermia.
Asunto(s)
Dióxido de Carbono/sangre , Hipotermia/fisiopatología , Oxígeno/sangre , Intercambio Gaseoso Pulmonar/fisiología , Respiración Artificial , Recalentamiento/métodos , Animales , Transporte Biológico , Temperatura Corporal/fisiología , Hipotermia/sangre , Hipotermia/terapia , Masculino , Consumo de Oxígeno/fisiología , Ratas , Ratas Wistar , Insuficiencia Respiratoria/sangre , Insuficiencia Respiratoria/fisiopatología , Insuficiencia Respiratoria/terapia , Factores de TiempoRESUMEN
Gas exchange, oxygen transport and utilisation were shown to be limited at body temperature 17.5 degrees C in rats. Disturbances in the cardio-vascular system seem to be the main limiting factors telling on the above parameters in the course of spontaneous rewarming.
Asunto(s)
Hipotermia/fisiopatología , Inmersión/fisiopatología , Consumo de Oxígeno/fisiología , Intercambio Gaseoso Pulmonar/fisiología , Recalentamiento , Animales , Temperatura Corporal/fisiología , Hipoxia/fisiopatología , Masculino , Ratas , Ratas Wistar , Recto , TemperaturaRESUMEN
Changes of the oxygen consumption and the main parameters of the blood respiratory function as well as oxygen transport, were studied in Wistar rats under conditions of immersion hypothermia (with rectal temperature 15-13 degrees C). From the viewpoint of the oxygen exchange, the rectal temperature 20 degrees C was found to be the critical level of the hypothermia.