Therapeutic Effect of Vanadium in Alloxan Diabetic Mice / 中国药理学通报

Vanadium (V) is one of the trace elements It exists in many oxidation states which exhibit different biological activities. Our results in alloxan diabetic mice suggest that NaVO3 and VOSO4 can decrease blood glucose level. The hy-poglycemic effest of VOSO4 was found to be weaker than that of NaVO3, the toxicity ofVOSO4 is also lower. However VOSO4; showed no effect in normal mice. The mechanism of the hypoglycemic effect of VOSO4 appears to be similar to that of insulin.