Deep learning-enhanced nuclear medicine SPECT imaging applied to cardiac studies.

Deep learning (DL) has a growing popularity and is a well-established method of artificial intelligence for data processing, especially for images and videos. Its applications in nuclear medicine are broad and include, among others, disease classification, image reconstruction, and image de-noising. Positron emission tomography (PET) and single-photon emission computerized tomography (SPECT) are major image acquisition technologies in nuclear medicine. Though several studies have been conducted to apply DL in many nuclear medicine domains, such as cancer detection and classification, few studies have employed such methods for cardiovascular disease applications. The present paper reviews recent DL approaches focused on cardiac SPECT imaging. Extensive research identified fifty-five related studies, which are discussed. The review distinguishes between major application domains, including cardiovascular disease diagnosis, SPECT attenuation correction, image denoising, full-count image estimation, and image reconstruction. In addition, major findings and dominant techniques employed for the mentioned task are revealed. Current limitations of DL approaches and future research directions are discussed.

AI-based classification algorithms in SPECT myocardial perfusion imaging for cardiovascular diagnosis: a review.

In the last few years, deep learning has made a breakthrough and established its position in machine learning classification problems in medical image analysis. Deep learning has recently displayed remarkable applicability in a range of different medical applications, as well as in nuclear cardiology. This paper implements a literature review protocol and reports the latest advances in artificial intelligence (AI)-based classification in SPECT myocardial perfusion imaging in heart disease diagnosis. The representative and most recent works are reported to demonstrate the use of AI and deep learning technologies in medical image analysis in nuclear cardiology for cardiovascular diagnosis. This review also analyses the primary outcomes of the presented research studies and suggests future directions focusing on the explainability of the deployed deep-learning systems in clinical practice.

Deep Learning-Based Automated Diagnosis for Coronary Artery Disease Using SPECT-MPI Images.

(1) Background: Single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) is a long-established estimation methodology for medical diagnosis using image classification illustrating conditions in coronary artery disease. For these procedures, convolutional neural networks have proven to be very beneficial in achieving near-optimal accuracy for the automatic classification of SPECT images. (2) Methods: This research addresses the supervised learning-based ideal observer image classification utilizing an RGB-CNN model in heart images to diagnose CAD. For comparison purposes, we employ VGG-16 and DenseNet-121 pre-trained networks that are indulged in an image dataset representing stress and rest mode heart states acquired by SPECT. In experimentally evaluating the method, we explore a wide repertoire of deep learning network setups in conjunction with various robust evaluation and exploitation metrics. Additionally, to overcome the image dataset cardinality restrictions, we take advantage of the data augmentation technique expanding the set into an adequate number. Further evaluation of the model was performed via 10-fold cross-validation to ensure our model's reliability. (3) Results: The proposed RGB-CNN model achieved an accuracy of 91.86%, while VGG-16 and DenseNet-121 reached 88.54% and 86.11%, respectively. (4) Conclusions: The abovementioned experiments verify that the newly developed deep learning models may be of great assistance in nuclear medicine and clinical decision-making.

Deep learning exploration for SPECT MPI polar map images classification in coronary artery disease.

OBJECTIVE: The exploration and the implementation of a deep learning method using a state-of-the-art convolutional neural network for the classification of polar maps represent myocardial perfusion for the detection of coronary artery disease. SUBJECTS AND METHODS: In the proposed research, the dataset includes stress and rest polar maps in attenuation-corrected (AC) and non-corrected (NAC) format, counting specifically 144 normal and 170 pathological cases. Due to the small number of the dataset, the following methods were implemented: First, transfer learning was conducted using VGG16, which is applied broadly in medical industry. Furthermore, data augmentation was utilized, wherein the images are rotated and flipped for expanding the dataset. Secondly, we evaluated a custom convolutional neural network called RGB CNN, which utilizes fewer parameters and is more lightweight. In addition, we utilized the k-fold validation for evaluating variability and overall performance of the examined model. RESULTS: Our RGB CNN model achieved an agreement rating of 92.07% with a loss of 0.2519. The transfer learning technique (VGG16) attained 95.83% accuracy. CONCLUSIONS: The proposed model could be an effective tool for medical classification problems, in the case of polar map data acquired from myocardial perfusion images.