1.
Bioorg Med Chem Lett
; 12(21): 3171-4, 2002 Nov 04.
Artículo
en Inglés
| MEDLINE
| ID: mdl-12372526
RESUMEN
The antimicrobial natural product chuangxinmycin has been found to be a potent and selective inhibitor of bacterial tryptophanyl tRNA synthetase (WRS). A number of analogues have been synthesised. The interaction with WRS appears to be highly constrained, as only sterically smaller analogues afforded significant inhibition. The only analogue to show inhibition comparable to chuangxinmycin also had antibacterial activity. WRS inhibition may contribute to the antibacterial action of chuangxinmycin.