High data-rate communication link supported through the exploitation of optical channels in a characterized turbulent underwater environment.

Underwater turbulence presents a myriad of challenges for underwater optical systems through wavefront distortion and beam deflection. In this work, an underwater turbulence emulator is developed and thoroughly characterized to experimentally test the proposed underwater turbulence mitigation technique. This technique applies a modified HOBBIT system introduced in atmospheric turbulence to the relatively unknown underwater turbulence domain. By varying a beam's spatial position and relative phase gradient, a volume of turbulence is rapidly probed to determine the beam state for optimal propagation. This probe and control method is applied in multiple facets, including improved optical power transmission as well as supporting a 25-Gbps communication link through a dynamic environment.

Synchronous optical intensity and phase measurements to characterize Rayleigh-Bénard convection.

Propagation of a laser beam through the Rayleigh-Bénard (RB) convection is experimentally investigated using synchronous optical wavefront and intensity measurements. Experimental results characterize the turbulence strength and length scales, which are used to inform numerical wave optic simulations employing phase screens. Experimentally found parameters are the refractive index structure constant, mean flow rate, kinetic and thermal dissipation rates, Kolmogorov microscale, outer scale, and shape of the refractive index power spectrum using known models. Synchronization of the wavefront and intensity measurements provide statistics of each metric at the same instance in time, allowing for two methods of comparison with numerical simulations. Numerical simulations prove to be within agreement of experimental and published results. Synchronized measurements provided more insight to develop reliable propagation models. It is determined that the RB test bed is applicable for simulating realistic undersea environments.

Sensing optical phase distortion via beatnote detection of a dual probe beam encoded with orbital angular momentum.

Laser based optical applications such as imaging, ranging, and wireless communications are susceptible to environmental distortions. Inferring the strength of these optical distortions is crucial to obtaining information about the environment in which the system is operating. Our technique of inferring environmental distortion strength leverages the spreading of light's orbital angular momentum (OAM) spectrum combined with heterodyne detection. A laser encoded with OAM can be decomposed into a basis set of helical modes that spreads upon interaction with optical distortions. This mode spreading is quantified using the OAM spectrum that can be measured using mode projection or mode sorting techniques. This new technique, to the best of our knowledge, provides benefits compared to the latter two OAM detection methods such as: low-frequency noise rejection, a simpler optical receiver, lower noise floor, and an inherent optical phase component. Central to the method is the heterodyne detection of the zeroth-order OAM coefficient of a superimposed two-beam, two-frequency, probe. The measured heterodyne signal power is seen to be proportional to the coupling power of each beam's OAM spectra. To test the idea, wave-optic simulations and experiments using spatial light modulators are implemented using a simplified optical turbulence model to represent the environment. The experimental implementation agrees well with simulated and theoretical results.

Weak turbulence effects on different beams carrying orbital angular momentum.

The study of beams carrying orbital angular momentum (OAM) has been of interest for its use in free-space optical communications (FSOC), directed energy applications, and remote sensing (RS). For FSOC and RS, it is necessary to measure the wavefront of the beam to recover transmitted or environmental information, respectively. In this computational study, common OAM beams such as the Laguerre-Gaussian (LG), Bessel-Gaussian (BG), and Bessel beams are propagated through atmospheric turbulence and compared to their Gaussian beam counterpart. The turbulence is simulated using multiple phase screens within the framework of a split-step method. Beam metrics used to quantify beam propagation will include the spatial coherence radius, OAM spectrum, on-axis intensity, spot size, divergence, and on-axis scintillation. Atmospheric turbulence along the path is limited to the weak scintillation limit, where beam parameters can be predicted analytically using the Rytov approximation. The results show that BG beams and multiplexed BG beams retain more OAM information than their LG and Bessel beam counterparts. The LG beam on-axis intensity and on-axis scintillation are seen to be independent of OAM mode. The scintillation of the LG beam is less than a BG, Bessel, and Gaussian beam across low- and high-order OAM modes. Insight into these results is discussed through studying the beam divergence, while the initial spot sizes of the Gaussian, LG, and BG beams are limited to the same spatial extent.

Photodynamic Therapy and the Biophysics of the Tumor Microenvironment.

Targeting the tumor microenvironment (TME) provides opportunities to modulate tumor physiology, enhance the delivery of therapeutic agents, impact immune response and overcome resistance. Photodynamic therapy (PDT) is a photochemistry-based, nonthermal modality that produces reactive molecular species at the site of light activation and is in the clinic for nononcologic and oncologic applications. The unique mechanisms and exquisite spatiotemporal control inherent to PDT enable selective modulation or destruction of the TME and cancer cells. Mechanical stress plays an important role in tumor growth and survival, with increasing implications for therapy design and drug delivery, but remains understudied in the context of PDT and PDT-based combinations. This review describes pharmacoengineering and bioengineering approaches in PDT to target cellular and noncellular components of the TME, as well as molecular targets on tumor and tumor-associated cells. Particular emphasis is placed on the role of mechanical stress in the context of targeted PDT regimens, and combinations, for primary and metastatic tumors.

Measuring the turbulence profile in the lower atmospheric boundary layer.

Optical turbulence can have a severe effect on the propagation of laser beams through the atmosphere. In free space optics and directed energy applications, these laser beams quite often propagate along a slant or vertical path. In these cases, the refractive index structure function parameter cannot be assumed constant, since it varies with height. How it varies with height, especially in the first few meters above the ground, is not well behaved. Turbulence height profiles have been measured since the 1970s, mainly for astronomical observations. These profiles are usually measured for the atmospheric boundary layer (the layer of air from the ground up to approx. 1 km during day and 100 m during night) and some kilometers above it. We have measured the temperature fluctuations in the first few meters above ground level using a system containing eight resistance thermometer devices, mounted in a row at different spacings. Measurements were made flying this system under a tethered balloon or mounted on a telescoping mast. The temperature structure function parameter, CT2, can be estimated from the temperature fluctuations measured by the 28 different probe pairs and the unique distances between the two probes. Finally, Cn2 is estimated from this temperature structure function parameter and compared to values predicted by a turbulence profile model.