Gastric Alimetry Expands Patient Phenotyping in Gastroduodenal Disorders Compared with Gastric Emptying Scintigraphy.

INTRODUCTION: Gastric emptying testing (GET) assesses gastric motility, however, is nonspecific and insensitive for neuromuscular disorders. Gastric Alimetry (GA) is a new medical device combining noninvasive gastric electrophysiological mapping and validated symptom profiling. This study assessed patient-specific phenotyping using GA compared with GET. METHODS: Patients with chronic gastroduodenal symptoms underwent simultaneous GET and GA, comprising a 30-minute baseline, 99m TC-labelled egg meal, and 4-hour postprandial recording. Results were referenced to normative ranges. Symptoms were profiled in the validated GA App and phenotyped using rule-based criteria based on their relationships to the meal and gastric activity: (i) sensorimotor, (ii) continuous, and (iii) other. RESULTS: Seventy-five patients were assessed, 77% female. Motility abnormality detection rates were as follows: GET 22.7% (14 delayed, 3 rapid), GA spectral analysis 33.3% (14 low rhythm stability/low amplitude, 5 high amplitude, and 6 abnormal frequency), and combined yield 42.7%. In patients with normal spectral analysis, GA symptom phenotypes included sensorimotor 17% (where symptoms strongly paired with gastric amplitude, median r = 0.61), continuous 30%, and other 53%. GA phenotypes showed superior correlations with Gastroparesis Cardinal Symptom Index, Patient Assessment of Upper Gastrointestinal Symptom Severity Index, and anxiety scales, whereas Rome IV Criteria did not correlate with psychometric scores ( P > 0.05). Delayed emptying was not predictive of specific GA phenotypes. DISCUSSION: GA improves patient phenotyping in chronic gastroduodenal disorders in the presence and absence of motility abnormalities with increased correlation with symptoms and psychometrics compared with gastric emptying status and Rome IV criteria. These findings have implications for the diagnostic profiling and personalized management of gastroduodenal disorders.

Gastric Alimetry ® improves patient phenotyping in gastroduodenal disorders compared to gastric emptying scintigraphy alone.

Objectives: Gastric emptying testing (GET) assesses gastric motility, however is non-specific and insensitive for neuromuscular disorders. Gastric Alimetry® (GA) is a new medical device combining non-invasive gastric electrophysiological mapping and validated symptom profiling. This study assessed patient-specific phenotyping using GA compared to GET. Methods: Patients with chronic gastroduodenal symptoms underwent simultaneous GET and GA, comprising a 30-minute baseline, 99m TC-labelled egg meal, and 4-hour postprandial recording. Results were referenced to normative ranges. Symptoms were profiled in the validated GA App and phenotyped using rule-based criteria based on their relationships to the meal and gastric activity: i) sensorimotor; ii) continuous; and iii) other. Results: 75 patients were assessed; 77% female. Motility abnormality detection rates were: GET 22.7% (14 delayed, 3 rapid); GA spectral analysis 33.3% (14 low rhythm stability / low amplitude; 5 high amplitude; 6 abnormal frequency); combined yield 42.7%. In patients with normal spectral analysis, GA symptom phenotypes included: sensorimotor 17% (where symptoms strongly paired with gastric amplitude; median r=0.61); continuous 30%; other 53%. GA phenotypes showed superior correlations with GCSI, PAGI-SYM, and anxiety scales, whereas Rome IV Criteria did not correlate with psychometric scores (p>0.05). Delayed emptying was not predictive of specific GA phenotypes. Conclusions: GA improves patient phenotyping in chronic gastroduodenal disorders in the presence and absence of motility abnormalities with improved correlation with symptoms and psychometrics compared to gastric emptying status and Rome IV criteria. These findings have implications for the diagnostic profiling and personalized management of gastroduodenal disorders. Study Highlights: 1) WHAT IS KNOWN Chronic gastroduodenal symptoms are common, costly and greatly impact on quality of lifeThere is a poor correlation between gastric emptying testing (GET) and symptomsGastric Alimetry® is a new medical device combining non-invasive gastric electrophysiological mapping and validated symptom profiling 2) WHAT IS NEW HERE Gastric Alimetry generates a 1.5x higher yield for motility abnormalities than GETWith symptom profiling, Gastric Alimetry identified 2.7x more specific patient categories than GETGastric Alimetry improves clinical phenotyping, with improved correlation with symptoms and psychometrics compared to GET.

The Correspondence Between Fluid Balance and Body Weight Change Measurements in Critically Ill Adult Patients.

INTRODUCTION: Positive fluid status has been associated with a worse prognosis in intensive care unit (ICU) patients. Given the potential for errors in the calculation of fluid balance totals and the problem of accounting for indiscernible fluid losses, measurement of body weight change is an alternative non-invasive method commonly used for estimating body fluid status. The objective of the study is to compare the measurements of fluid balance and body weight changes over time and to assess their association with ICU mortality. METHODS: This prospective observational study was conducted in the 34-bed multidisciplinary ICU of a tertiary teaching hospital in southern Brazil. Adult patients were eligible if their expected length of stay was more than 48 hours, and if they were not receiving an oral diet. Clinical demographic data, daily and cumulative fluid balance with and without indiscernible water loss, and daily and total body weight changes were recorded. Agreement between daily fluid balance and body weight change, and between cumulative fluid balance and total body weight change were calculated. RESULTS: Cumulative fluid balance and total body weight change differed significantly among survivors and non survivors respectively, +2.53L versus +5.6L (p= 0.012) and -3.05kg vs -1.1kg (p= 0.008). The average daily difference between measured fluid balance and body weight was +0.864 L/kg with a wide interval: -3.156 to +4.885 L/kg, which remained so even after adjustment for indiscernible losses (mean bias: +0.288; limits of agreement between -3.876 and +4.452 L/kg). Areas under ROC curve for cumulative fluid balance, cumulative fluid balance with indiscernible losses and total body weight change were, respectively, 0.65, 0.56 and 0.65 (p= 0.14). CONCLUSION: The results indicated the absence of correspondence between fluid balance and body weight change, with a more significant discrepancy between cumulative fluid balance and total body weight change. Both fluid balance and body weight changes were significantly different among survivors and non-survivors, but neither measurement discriminated ICU mortality.

Accuracy of Defining Characteristics for Nursing Diagnoses Related to Patients with Respiratory Deterioration.

PURPOSE: To evaluate accuracy of defining characteristics (DCs) for impaired gas exchange (IGE), impaired spontaneous ventilation (ISV), and ineffective breathing pattern (IBP) in respiratory deterioration. METHODS: This study is a retrospective analysis of medical records. The accuracy and predictive ability of DC or of clusters are calculated. FINDINGS: In this study, 391 records were evaluated. For IGE, DCs or clusters with higher efficiency were "hypercapnia" (78%), "somnolence" (74.4%), and "hypercapnia + tachycardia" (88%); for ISV, the cluster with higher efficiency was "increased heart rate ± decrease in cooperation" (70.1%); and for IBP, no DC or cluster exceeded 70% efficiency. These were confirmed by logistic regression. CONCLUSION: Few DCs had adequate efficiency for respiratory nursing diagnoses, while in some cases clusters accounted for higher efficiency. IMPLICATIONS FOR NURSING PRACTICE: Clusters of DC may be relevant for respiratory diagnoses.

Implantação de protocolo de qualidade assistencial baseado em cuidados centrados no paciente crítico: relato de experiência / Implementation of care-based care-based care quality protocol: experience report / Implementación del protocolo de calidad asistencial basado en el cuidado centrado en el paciente: informe de experiencia

OBJETIVO: descrever as etapas da construção e implantação de um protocolo de qualidade assistencial, baseado no bundle ABCDEF, adaptado às necessidades locais, integrando-o à visão de cuidado centrado no paciente, vivenciadas pelo grupo multiprofissional pelo olhar dos enfermeiros. MÉTODO: trata-se de relato de experiência da construção e implantação parcial de um protocolo de qualidade assistencial, baseado nas orientações do PAD inserido no Programa de Qualidade Assistencial "ABCDEF", que aborda o manejo da analgesia, da sedação e do delirium, englobando os protocolos de desmame de ventilação mecânica, mobilização precoce, higiene do sono e humanização desde a admissão na UTI. RESULTADOS: foram implantados, até o momento, os protocolos de sedoanalgesia, desmame da ventilação mecânica e mobilização precoce. Estes passaram por ampla discussão com a equipe assistencial multiprofissional antes da implantação. CONCLUSÃO: inúmeros são os fatores que facilitam e dificultam a implantação do bundle ABCDEF em nossa realidade. A proposta de mudança é bem aceita pelo grupo, mas a adesão não é constante. Esforços intensos com educação permanente, encontros com equipe multiprofissional e valorização do trabalho pelos gestores parecem melhorar o engajamento.(AU)

Objective: to describe the stages of the elaboration and implementation of a quality care protocol, based on the ABCDEF bundle, adapted to local needs, integrating it with the patient-centered view of care experienced by the multiprofessional group through the eyes of nurses. Method: this is an experience report of the elaboration and partial implementation of a care quality protocol, based on the PAD guidelines inserted in the Care Quality Program "ABCDEF", which addresses the management of analgesia, sedation and delirium, encompassing discontinuation of mechanical ventilation, early mobilization, sleep hygiene and humanization protocols since ICU admission. Results: the protocols of sedoanalgesia, discontinuation of mechanical ventilation and early mobilization were implemented so far. These underwent extensive discussion with the multidisciplinary care team prior to implementation. Conclusion: there are many factors that facilitate and hinder the implementation of ABCDEF bundle in our reality. The change proposal is well accepted by the group, but adherence is not constant. Intense efforts with continuing education, meetings with multiprofessional staff and appreciation of work by managers seem to improve engagement.(AU)

Objetivo: describir las etapas de la construcción e implementación de un protocolo de calidad asistencial, basado en el paquete de medidas ABCDEF, adaptado a las necesidades locales, integrándolo con la visión de la atención centrada en el paciente, experimentada por el grupo multiprofesional a través de los ojos de los enfermeros. Método: informe de experiencia de la construcción e implementación parcial de un protocolo de calidad asistencial, basado en las pautas de PAD insertadas en el Programa de Calidad Asistencial "ABCDEF", que trata del manejo de la analgesia, sedación y del delirio, que incluye los protocolos de destete de ventilación mecánica, movilización temprana, higiene del sueño y humanización desde la admisión a la UCI. Resultados: hasta el momento fueron implementados los protocolos de sedoanalgesia, de destete de la ventilación mecánica y de movilización temprana. Estos se sometieron a una extensa discusión con el equipo de atención multiprofesional antes de la implementación. Conclusión: hay muchos factores que facilitan y dificultan la implementación del paquete de medidas ABCDEF en nuestra realidad. La propuesta de cambio es bien aceptada por el grupo, pero la adhesión no es constante. Esfuerzos intensos con educación continua, reuniones con el personal multiprofesional y la apreciación del trabajo por parte de los gerentes parecen mejorar el compromiso.(AU)

Multiprofessional care for delirium patients in intensive care: integrative review. / Cuidados multiprofissionais para pacientes em delirium em terapia intensiva: revisão integrativa.

OBJECTIVE: To describe the multiprofessional care for the management of critical patients in delirium in the ICU from the evidences found in the literature. METHODS: This integrative review was carried out in the period from February 1 to June 30, 2016 through searches on PubMed, Scopus, Web of Science, and CINAHL, with the following descriptors: delirium, critical care e intensive care units, which brought up 17 original papers. RESULTS: A bundle and a guideline, two systematic reviews, evidence 1a and four clinical trials, evidence 1b and 2b, cohort and observational studies were found. The multiprofessional care was presented to better understand the diagnosis of delirium, sedation pause, early mobilization, pain, agitation and delirium guidelines, psychomotor agitation, cognitive orientation, sleep promotion, environment and family participation. CONCLUSION: The care for delirium is wide and not specific, which determines its multifactorial aspect.

Cuidados multiprofissionais para pacientes em delirium em terapia intensiva: revisão integrativa / Cuidados multiprofesionales para pacientes en delirium en la terapia intensiva: revisión integrativa / Multiprofessional care for delirium patients in intensive care: integrative review

Resumo OBJETIVO Descrever os cuidados multiprofissionais para manejo de pacientes críticos em delirium na UTI a partir das evidências encontradas na literatura. MÉTODOS Trata-se de uma revisão integrativa realizada no período de 1º de fevereiro a 30 de junho de 2016 através de busca nas bases de dados PubMed, Scopus, Web of Science e CINAHL com os descritores delirium, critical care e intensive care units que finalizou com 17 estudos originais. RESULTADOS Foram encontrados um bundle e uma diretriz, duas revisões sistemáticas, evidência 1a e quatro ensaios clínicos, evidência 1b e 2b, os demais estudos de coorte e observacionais. Os cuidados multiprofissionais foram apresentados para melhor entendimento em diagnóstico de delirium, pausa de sedação, mobilização precoce, diretrizes para dor, agitação e delirium, agitação psicomotora, orientação cognitiva, promoção do sono, ambiente e participação da família. CONCLUSÃO Os cuidados para delirium são abrangentes e pouco específicos, determinando seu aspecto multifatorial.

Resumen OBJETIVO Se objetivó describir los cuidados multiprofesionales para manejo de pacientes críticos en delirium en la UTI a partir de las evidencias encontradas en la literatura. MÉTODOS Se trata de una revisión integradora realizada en el período del 1 de febrero al 30 de junio de 2016 a través de búsqueda en PubMed, Scopus, Web of Science, and CINAHL con descriptores delirium, critical care e intensive care units que finalizó 17 estudios originales. RESULTADOS Fueron encontrados un bundle, una directriz, dos revisiones sistemáticos, evidencia 1a, cuatro ensayos clínicos, evidencia 1b y 2b, los demás estudios de cohorte y observacionales. Los cuidados multiprofesionales fueron presentados para mejor entenderse el diagnóstico de delirium, pausa de sedación, movilización temprana, directrices para dolor, agitación, y delirium, agitación psicomotora, orientación cognitiva, promoción de sueño, ambiente y participación de la familia. CONCLUSIÓN Los cuidados para delirium son más amplio y poco específicos, determinando su aspecto multifactorial.

Abstract OBJECTIVE To describe the multiprofessional care for the management of critical patients in delirium in the ICU from the evidences found in the literature. METHODS This integrative review was carried out in the period from February 1 to June 30, 2016 through searches on PubMed, Scopus, Web of Science, and CINAHL, with the following descriptors: delirium, critical care e intensive care units, which brought up 17 original papers. RESULTS A bundle and a guideline, two systematic reviews, evidence 1a and four clinical trials, evidence 1b and 2b, cohort and observational studies were found. The multiprofessional care was presented to better understand the diagnosis of delirium, sedation pause, early mobilization, pain, agitation and delirium guidelines, psychomotor agitation, cognitive orientation, sleep promotion, environment and family participation. CONCLUSION The care for delirium is wide and not specific, which determines its multifactorial aspect.

Profound thrombocytopenia related to G-CSF.

Severe thrombocytopenia in association with G-CSF therapy is extremely rare. Here we report a case of profound thrombocytopenia in a 57-year-old male with refractory cardiac ischemia, who received G-CSF during an angiogenesis trial. After 5 days of G-CSF therapy (10 microg/kg/day) the platelet count fell progressively to a nadir of 5x10(9)/L. The patient received steroid, immunoglobulin and platelet support and recovered without sequelae. Subsequent investigations suggested an underlying immune-mediated thrombocytopenia, which we hypothesize was exacerbated by G-CSF therapy.