RESUMEN
BACKGROUND: Oxidative stress has been intensively studied as a key biochemical system in the pathophysiology of schizophrenia. However, little is known about the implication of oxidative stress in the development of physical illnesses in schizophrenia patients, who are characterized by high cardiovascular risk and decreased life expectancy. Advanced glycation end-products (AGEs) are considered to be markers of oxidative stress and are linked to the development of atherosclerosis. METHODS: We investigated AGE levels determined by a noninvasive skin autofluorescence (skin AF) method (AGE-Reader™) in schizophrenia patients. Skin AF was assessed in 55 schizophrenia patients without diabetes or renal disease and 55 healthy controls matched for age, gender and smoking status. Nineteen of the 55 schizophrenia patients had a severe form of the disease (Kraepelinian schizophrenia). RESULTS: Skin AF was significantly higher in schizophrenia patients compared to controls (2.46 ± 0.52 and 1.90 ± 0.21, respectively, p < 0.0001). Kraepelinian schizophrenia patients had significantly higher skin AF than non-Kraepelinian schizophrenia patients (p = 0.05). CONCLUSIONS: This is the first study to demonstrate high AGE levels assessed by a noninvasive method in schizophrenia patients.
Asunto(s)
Productos Finales de Glicación Avanzada/metabolismo , Imagen Óptica/métodos , Esquizofrenia/diagnóstico , Esquizofrenia/patología , Piel/metabolismo , Adulto , Estudios de Casos y Controles , Catatonia/patología , Demencia/patología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Análisis Multivariante , Proyectos PilotoRESUMEN
Kraepelinian schizophrenia, defined as a severe form of the disease, is characterized by a high number of negative symptoms and less depression, respectively. The relationship between anhedonia and Kraepelinian schizophrenia was explored. Depressive and trait anticipatory and consummatory anhedonia were compared in Kraepelinian (n=10, M age 49.2 yr., SD=10.8) and non-Kraepelinian (n=23, M age=42.7 yr., SD=10.8) patients with schizophrenia. The Kraepelinian group had more anticipatory and consummatory anhedonia than the non-Kraepe-linian group. The two groups did not differ on depressive anhedonia or depression.