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1.
ESMO Open ; 9(7): 103632, 2024 Jul 05.
Artículo en Inglés | MEDLINE | ID: mdl-38970840

RESUMEN

BACKGROUND: Data regarding the clinical outcome of patients with immune checkpoint inhibitor (ICI)-induced colitis are scant. We aimed to describe the 12-month clinical outcome of patients with ICI-induced colitis. MATERIALS AND METHODS: This was a retrospective, European, multicentre study. Endoscopy/histology-proven ICI-induced colitis patients were enrolled. The 12-month clinical remission rate, defined as a Common Terminology Criteria for Adverse Events diarrhoea grade of 0-1, and the correlates of 12-month remission were assessed. RESULTS: Ninety-six patients [male:female ratio 1.5:1; median age 65 years, interquartile range (IQR) 55.5-71.5 years] were included. Lung cancer (41, 42.7%) and melanoma (30, 31.2%) were the most common cancers. ICI-related gastrointestinal symptoms occurred at a median time of 4 months (IQR 2-7 months). An inflammatory bowel disease (IBD)-like pattern was present in 74 patients (77.1%) [35 (47.3%) ulcerative colitis (UC)-like, 11 (14.9%) Crohn's disease (CD)-like, 28 (37.8%) IBD-like unclassified], while microscopic colitis was present in 19 patients (19.8%). As a first line, systemic steroids were the most prescribed drugs (65, 67.7%). The 12-month clinical remission rate was 47.7 per 100 person-years [95% confidence interval (CI) 33.5-67.8). ICI was discontinued due to colitis in 66 patients (79.5%). A CD-like pattern was associated with remission failure (hazard ratio 3.84, 95% CI 1.16-12.69). Having histopathological signs of microscopic colitis (P = 0.049) and microscopic versus UC-/CD-like colitis (P = 0.014) were associated with a better outcome. Discontinuing the ICI was not related to the 12-month remission (P = 0.483). Four patients (3.1%) died from ICI-induced colitis. CONCLUSIONS: Patients with IBD-like colitis may need an early and more aggressive treatment. Future studies should focus on how to improve long-term clinical outcomes.

2.
Environ Monit Assess ; 196(6): 566, 2024 May 22.
Artículo en Inglés | MEDLINE | ID: mdl-38775858

RESUMEN

Microbial communities from freshwater sediments are involved in biogeochemical cycles and they can be modified by physical and chemical changes in the environment. Linking the microbial community structure (MCS) with physicochemistry of freshwater courses allows a better understanding of its ecology and can be useful to assess the ecological impact generated by human activity. The MCS of tributary channels from La Plata River affected by oil refinery (C, D, and E) and one also by urban discharges (C) was studied. For this purpose, 16S rRNA metabarcoding analysis, in silico metagenome functional prediction, and the hydrocarbon degradation potential (in silico predictions of hydrocarbon-degrading genes and their quantification by qPCR) of the MCS were studied. Principal coordinate analysis revealed that the MCS was different between sites, and it was not structured by the hydrocarbon content. Site C showed physicochemical characteristics, bacterial taxa, and an in silico functional prediction related to fermentative/heterotrophic metabolism. Site D, despite having higher concentration of hydrocarbon, presented autotrophic, syntrophic, and methanogenic pathways commonly involved in natural processes in anoxic sediments. Site E showed and intermediate autotrophic/heterotrophic behavior. The hydrocarbon degradation potential showed no positive correlation between the hydrocarbon-degrading genes quantified and predicted. The results suggest that the hydrocarbon concentration in the sites was not enough selection pressure to structure the bacterial community composition. Understanding which is the variable that structures the bacterial community composition is essential for monitoring and designing of sustainable management strategies for contaminated freshwater ecosystems.


Asunto(s)
Monitoreo del Ambiente , Microbiota , Ríos , Contaminantes Químicos del Agua , Ríos/microbiología , Ríos/química , Contaminantes Químicos del Agua/metabolismo , Contaminantes Químicos del Agua/análisis , Argentina , ARN Ribosómico 16S/genética , Biodegradación Ambiental , Hidrocarburos/metabolismo , Sedimentos Geológicos/microbiología , Sedimentos Geológicos/química , Bacterias/metabolismo , Bacterias/clasificación , Bacterias/genética , Restauración y Remediación Ambiental/métodos
3.
J Appl Microbiol ; 124(6): 1532-1543, 2018 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-29473990

RESUMEN

AIM: To analyse the physiological response of Sphingobium sp. 22B to water stress. METHODS AND RESULTS: The strain was grown under excess of carbon source and then subjected to low (60RH) and high (18RH) water stress conditions for 96 h. Quantification of trehalose, glycogen, polyhydroxybutyrate (PHB) and transmission electron microscopy (TEM) was studied. Genes linked with desiccation were searched in Sphingobium sp. 22B and Sphingomonas 'sensu latu' genomes and their transcripts were quantified by real-time PCR. Results showed that, in the absence of water stress, strain 22B accumulated 4·76 ± 1·41% of glycogen, 0·84 ± 1·62% of trehalose and 44·9 ± 6·4% of PHB per cellular dry weight. Glycogen and trehalose were mobilized under water stressed conditions, this mobilization was significantly higher in 60RH in comparison to 18RH. Gene treY was upregulated sixfold in 60RH relative to control condition. TEM and quantification of PHB revealed that PHB was mobilized under 60RH condition accompanied by the downregulation of the phbB gene. TEM images showed an extracellular amorphous matrix in 18RH and 60RH. Major differences were found in the presence of aqpZ and trehalose genes between strain 22B and Sphingomonas genomes. CONCLUSION: Strain 22B showed a carbon conservative metabolism capable of accumulation of three types of endogenous carbon sources. The strain responds to water stress by changing the expression pattern of genes related to desiccation, formation of an extracellular amorphous matrix and mobilization of the carbon sources according to the degree of water stress. Trehalose, glycogen and PHB may have multiple functions in different degrees of desiccation. The robust endowment of molecular responses to desiccation shown in Sphingobium sp. 22B could explain its survival in semi-arid soil. SIGNIFICANCE AND IMPACT OF THE STUDY: Understanding the physiology implicated in the toleration of the PAH-degrading strain Sphingobium sp 22B to environmental desiccation may improve the bioaugmentation technologies in semi-arid hydrocarbon-contaminated soils.


Asunto(s)
Adaptación Fisiológica/fisiología , Viabilidad Microbiana , Sphingomonadaceae/fisiología , Agua/metabolismo , Argentina , Chile , Glucógeno/metabolismo , Humedad , Microbiología del Suelo , Sphingomonadaceae/genética , Sphingomonadaceae/metabolismo , Trehalosa/metabolismo
4.
Eur Rev Med Pharmacol Sci ; 19(19): 3674-81, 2015 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-26502857

RESUMEN

OBJECTIVE: Ulcerative Colitis (UC) is a chronic inflammatory disease of the colon of unknown etiology. Several clinical indexes have been proposed for UC disease activity evaluation, but none have been properly validated. Moreover, the reference parameter for the scores and their prognostic value is not clear. Mucosal healing has been recently proposed as an important end-point. Aim of the present study was to evaluate the correlation of four clinical indexes with objective diagnostic tools for UC evaluation, the discriminative ability in identifying patients with endoscopic mucosal healing, and to analyze the possible prognostic indication for disease course in 1 year of follow-up. PATIENTS AND METHODS: We analyzed data of 75 patients recorded in regular follow-up visit in IBD clinic at S. Andrea Hospital, Rome, between 2007-2011. We recorded clinical data and lab tests at the time of the visit, and endoscopic/histological reports performed within 1 month. Clinical indexes (Seo' activity index, Simple Clinical Colitis Activity Index, partial Mayo score and Endoscopic-Clinical Correlation Index) were calculated and correlation to endoscopic and histologic activity, and to C-reactive protein increment, was assessed by mean of Spearman's rank correlation. Discriminative ability of the indexes for patients with and without endoscopic mucosal healing was tested by calculation of area under ROC curve (AUC). Patients with low and high clinical scores were compared for number of flares and increment of therapy during 1 year of follow-up. RESULTS: Clinical indexes had a good correlation with endoscopic activity (mean r = 0.73 ± 0.06), a fair correlation with CRP-increment (mean r = 0.55 ± 0.01) and a poor one with histologic activity (mean r = 0.35 ± 0.01). The discriminatory ability of the indexes for endoscopic mucosal healing was good for all the indexes (mean AUC = 0.87 ± 0.05). Patients with high clinical score had more flares and required more frequently increase of therapy at 1 year of follow up compared with patients with low score. CONCLUSIONS: Clinical indexes have a good correlation with endoscopic activity and can discriminate patients with and without mucosal healing. Patients with low and high score have different risk of disease flare and of need to increase therapy at 1 year. Clinical indexes may represent a useful tool for disease assessment in clinical practice in UC outpatients with mild-moderate disease.


Asunto(s)
Colitis Ulcerosa/diagnóstico , Colitis Ulcerosa/terapia , Manejo de la Enfermedad , Endoscopía Gastrointestinal/métodos , Mucosa Intestinal/patología , Índice de Severidad de la Enfermedad , Cicatrización de Heridas/fisiología , Adulto , Anciano , Proteína C-Reactiva/análisis , Colitis Ulcerosa/metabolismo , Progresión de la Enfermedad , Femenino , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad
5.
Cardiovasc Intervent Radiol ; 23(3): 232-4, 2000.
Artículo en Inglés | MEDLINE | ID: mdl-10821902

RESUMEN

Though polycystic liver disease (PCLD) has historically been considered a contraindication to TIPS, we present a case where technically successful shunt creation was achieved without the need for modification of the standard TIPS procedure, as was required in a previous report.


Asunto(s)
Ascitis/cirugía , Quistes/cirugía , Hepatopatías/cirugía , Derivación Portosistémica Intrahepática Transyugular/métodos , Ascitis/etiología , Quistes/complicaciones , Quistes/diagnóstico , Resultado Fatal , Femenino , Estudios de Seguimiento , Humanos , Hepatopatías/complicaciones , Hepatopatías/diagnóstico , Persona de Mediana Edad , Índice de Severidad de la Enfermedad , Tomografía Computarizada por Rayos X , Ultrasonografía Doppler
6.
Neuroradiology ; 41(11): 820-5, 1999 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-10602854

RESUMEN

Peritumoral edema and contrast enhancement of brain tumors are both thought to be due to breakdown of the blood-brain barrier (BBB); however, the exact mechanism by which these two phenomena occur and whether there is a quantitative or etiological relationship is not known. Our purpose was to determine whether the relationship between the breakdown of the BBB, defined radiologically as the degree of contrast enhancement, and the volume of surrounding edema is different for high-grade gliomas and meningiomas. We analyzed 13 meningiomas and 23 gliomas. A direct linear relationship between the degree of contrast enhancement (dC) and volume of peritumoral edema (V) with a high correlation coefficient (R = 0.66, P = 0.0006) was established for gliomas. A mathematical relationship between dC and V could not be established for meningioma. The findings for gliomas offer indirect radiological evidence that the defect in the BBB which causes edema is quantitatively and etiologically related to the defect in the BBB responsible for contrast enhancement. For meningiomas, the lack of a relationship between dC and V implies either that the mechanisms responsible for formation of edema and contrast enhancement are fundamentally different or that a physical barrier in certain meningiomas limits propagation of edema into the adjacent white matter.


Asunto(s)
Edema Encefálico/patología , Neoplasias Encefálicas/complicaciones , Medios de Contraste , Glioma/complicaciones , Aumento de la Imagen , Imagen por Resonancia Magnética , Neoplasias Meníngeas/complicaciones , Meningioma/complicaciones , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Astrocitoma/complicaciones , Astrocitoma/patología , Barrera Hematoencefálica , Encéfalo/patología , Encéfalo/ultraestructura , Edema Encefálico/etiología , Neoplasias Encefálicas/patología , Gadolinio DTPA , Glioblastoma/complicaciones , Glioblastoma/patología , Glioma/patología , Humanos , Procesamiento de Imagen Asistido por Computador , Neoplasias Meníngeas/patología , Meningioma/patología , Persona de Mediana Edad , Estudios Retrospectivos
7.
Radiol Clin North Am ; 37(5): 1035-44, 1999 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-10494282

RESUMEN

None of these models will automatically come to pass but all are possible today. Radiologists have to realize that the teleimaging era for emergency patients is here to stay. Successful utilization for good and gain may no longer be accomplished by a reliance on old or outmoded practice assumptions. The virtual turf, prepared by the rapidity of the remote transmission of electronically generated pictures, is a real phenomenon for which radiology has and will play a major role. The practice opportunities may not be vast in scope, but on a regional basis the imaging landscape is still green and up for grabs.


Asunto(s)
Tratamiento de Urgencia/métodos , Telerradiología/tendencias , Humanos , Telerradiología/economía , Telerradiología/legislación & jurisprudencia , Telerradiología/normas , Estados Unidos
8.
Neuroradiology ; 41(1): 52-4, 1999 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-9987770

RESUMEN

We report the CT findings of a solitary fibrous tumor of the orbit. The radiologic features included relatively homogeneous contrast enhancement and smooth remodelling of the bones of the orbit, findings consistent with the benign nature of this relatively rare tumor.


Asunto(s)
Neoplasias Orbitales/diagnóstico por imagen , Tomografía Computarizada por Rayos X , Humanos , Masculino , Mesotelioma/diagnóstico por imagen , Mesotelioma/patología , Persona de Mediana Edad , Neoplasias Orbitales/patología
9.
South Med J ; 91(8): 765-7, 1998 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-9715227

RESUMEN

Fat necrosis follows many forms of trauma to the breast, including surgery. In unusual cases, it may be extensive enough to present as a palpable mass on physical examination with mammographic features suggestive of cancer. In these instances, regardless of patient age, surgical history, or multifocality, a biopsy must be done to exclude carcinoma. We describe a young woman who was evaluated for bilateral breast masses with highly suspicious imaging characteristics 2 years after having reduction mammoplasty.


Asunto(s)
Enfermedades de la Mama/diagnóstico , Enfermedades de la Mama/etiología , Neoplasias de la Mama/diagnóstico , Necrosis Grasa/diagnóstico , Necrosis Grasa/etiología , Mamoplastia , Adulto , Diagnóstico Diferencial , Femenino , Humanos , Mamografía , Complicaciones Posoperatorias
10.
N J Med ; 91(1): 37-8, 1994 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-8115064

RESUMEN

The authors discuss hydrocele in the female processus vaginalis (hydrocele in the canal of Nuck) and present new case reports. The treatment of choice is surgical excision. The hydrocele is excised through a groin incision. The authors present four new cases.


Asunto(s)
Enfermedades de los Genitales Femeninos , Hidrocele Testicular , Adolescente , Adulto , Femenino , Enfermedades de los Genitales Femeninos/diagnóstico , Enfermedades de los Genitales Femeninos/patología , Hernia Inguinal/diagnóstico , Humanos , Masculino , Persona de Mediana Edad , Hidrocele Testicular/diagnóstico , Hidrocele Testicular/patología
13.
Minerva Pediatr ; 41(11): 571-6, 1989 Nov.
Artículo en Italiano | MEDLINE | ID: mdl-2695813

RESUMEN

Authors review the most common laboratory tests showing an immunologic response caused by group A beta-hemolytic streptococcus infections. After a preliminary evaluation on characteristics and peculiarities of different methods the results obtained are compared with the usually employed systems. The survey of most common analytical methods and personal experience lead to confirm and emphasize the laboratory results supporting and confirming, without substituting, the clinical data.


Asunto(s)
Antiestreptolisina/análisis , Hidrolasas/sangre , Cardiopatía Reumática/diagnóstico , Streptococcus agalactiae/inmunología , Adolescente , Niño , Preescolar , Humanos , Lactante , Recién Nacido , Valor Predictivo de las Pruebas , Cardiopatía Reumática/sangre , Cardiopatía Reumática/inmunología , Pruebas Serológicas , Estreptoquinasa/sangre , Estreptolisinas/sangre
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