RESUMEN
A total of 371 children, aged 6 months to 12 years, with acute otitis media, acute sinusitis, streptococcal tonsillitis/pharyngitis, or pneumonia were included in an open, multicenter study. Among them, 192 children were randomized to receive azithromycin for 3 days (10 mg/kg daily), and 179 for 5 days (10 mg/kg on day 1 and 5 mg/kg on days 2-5). The overall clinical cure rate was 95.7% and 96.1%, and bacteriological eradication rate 90.1% and 94.2% in the 3-day and 5-day groups, respectively. Side effects, mostly mild gastrointestinal disturbances, were observed in 5.3% of children from the 3-day, and 6.7% from the 5-day group. Only in one child (0.3%) was therapy discontinued due to vomiting. The results of this study demonstrate that 3-day and 5-day azithromycin courses have comparable efficacy and tolerability in children with respiratory infections.
Asunto(s)
Antibacterianos/uso terapéutico , Azitromicina/uso terapéutico , Infecciones del Sistema Respiratorio/tratamiento farmacológico , Antibacterianos/efectos adversos , Azitromicina/efectos adversos , Técnicas Bacteriológicas , Niño , Preescolar , Esquema de Medicación , Femenino , Humanos , Lactante , Masculino , Resultado del TratamientoRESUMEN
The authors present the diagnostic examinations used in two boys 12 and 14 years of age exposed to lead in an unusual way. No specific treatment was required except the removal from the further exposition to lead. The information provided by this presentation may form a reminder to general practitioners on possible etiologic part of lead intoxication in numerous non-typical, subclinical forms of diseases. Therefore, diagnostic methods, staging of the disease, specific treatment, and prevention are also discussed.