Schistosoma mansoni granulomas in the skeletal striated muscles in the murine model of neuroschistosomiasis: histological findings.

Schistosomiasis mansoni presents many clinical manifestations during migration of schistosomes in their hosts, including diarrhea, hepatomegaly, splenomegaly, liver abscesses, skinlesions, brain tumors and myeloradiculopathy. No lesions have been reported in skeletal striated muscles due to schistosomiasis mansoni in the literature. This short communication reports the histopathological findings on skeletal musculature in a murine model of neuroeschistosomiasis mansoni. Lesions were found in the tongue, masseter muscle, buccinator muscle, digastric muscle and temporalis muscle. Worm recovery was carried out to confirm the infection. We describe here, for the first time in the literature, injuries in the skeletal musculature due to Schistosoma mansoni nfection.

Characterisation of ocular involvement in an experimental model of neuroschistosomiasis mansoni.

The Global Burden of Disease Study 2010 listed schistosomiasis among the leading 100 causes of death in Brazil, responsible for 3.6% of the estimated total of deaths globally. Eye and adnexa are very rarely affected by schistosomiasis mansoni, with limited documentation of ocular pathology in this setting. This short communication reports ocular histolopathological findings in a murine model of neuroschistosomiasis mansoni. Lesions were found in the bulbar conjunctiva, lacrimal gland, choroid and corneoscleral limbus.

Sensitivity and specificity of the circulating cathodic antigen rapid urine test in the diagnosis of Schistosomiasis mansoni infection and evaluation of morbidity in a low- endemic area in Brazil.

INTRODUCTION:: The Kato-Katz technique is the standard diagnostic test for Schistosoma mansoni infection in rural areas. However, the utility of this method is severely limited by the day-to-day variability in host egg excretion in the stool. In high-transmission areas, the point-of-care circulating cathodic antigen (POC-CCA) urine assay has proven to be a reliable test. However, investigations of the reliability of the POC-CCA assay in low-transmission regions are under way. This study aimed to evaluate the sensitivity and specificity of the POC-CCA assay and the morbidity of schistosomiasis in a low-endemic area in Brazil. METHODS:: Pains City is a low-transmission zone for schistosomiasis. A total of 300 subjects aged 7-76 years were randomly selected for the POC-CCA cassette test. For S. mansoni diagnosis, three stool samples on six slides were compared with one urine sample for each subject. The sensitivity and specificity in the absence of a gold standard were calculated using latent class analysis. Clinical examinations and abdominal ultrasounds were performed in 181 volunteers to evaluate morbidity associated with schistosomiasis. RESULTS:: The sensitivity and specificity of the Kato-Katz technique were 25.6% and 94.6%, respectively. By contrast, the sensitivity and specificity of the POC-CCA assay were 68.1% and 72.8%, respectively. Hepatosplenic schistosomiasis was diagnosed in two patients (1.1%). CONCLUSIONS:: Overall, the POC-CCA urine assay proved to be a useful test for diagnosing S. mansoni in a low-endemic area in Brazil. Severe clinical forms of schistosomiasis can be present even in such low-endemic areas.

Sensitivity and specificity of the circulating cathodic antigen rapid urine test in the diagnosis of Schistosomiasis mansoni infection and evaluation of morbidity in a low- endemic area in Brazil

Abstract INTRODUCTION: The Kato-Katz technique is the standard diagnostic test for Schistosoma mansoni infection in rural areas. However, the utility of this method is severely limited by the day-to-day variability in host egg excretion in the stool. In high-transmission areas, the point-of-care circulating cathodic antigen (POC-CCA) urine assay has proven to be a reliable test. However, investigations of the reliability of the POC-CCA assay in low-transmission regions are under way. This study aimed to evaluate the sensitivity and specificity of the POC-CCA assay and the morbidity of schistosomiasis in a low-endemic area in Brazil. METHODS: Pains City is a low-transmission zone for schistosomiasis. A total of 300 subjects aged 7-76 years were randomly selected for the POC-CCA cassette test. For S. mansoni diagnosis, three stool samples on six slides were compared with one urine sample for each subject. The sensitivity and specificity in the absence of a gold standard were calculated using latent class analysis. Clinical examinations and abdominal ultrasounds were performed in 181 volunteers to evaluate morbidity associated with schistosomiasis. RESULTS: The sensitivity and specificity of the Kato-Katz technique were 25.6% and 94.6%, respectively. By contrast, the sensitivity and specificity of the POC-CCA assay were 68.1% and 72.8%, respectively. Hepatosplenic schistosomiasis was diagnosed in two patients (1.1%). CONCLUSIONS: Overall, the POC-CCA urine assay proved to be a useful test for diagnosing S. mansoni in a low-endemic area in Brazil. Severe clinical forms of schistosomiasis can be present even in such low-endemic areas.

Brain schistosomiasis in mice experimentally infected with Schistosoma mansoni.

INTRODUCTION: Human neuroschistosomiasis has been reported in the literature, but the possibility of modeling neuroschistosomiasis in mice is controversial. METHODS: In two research laboratories in Brazil that maintain the Schistosoma mansoni life cycle in rodents, two mice developed signs of brain disease (hemiplegia and spinning), and both were autopsied. RESULTS: S. mansoni eggs, both with and without granuloma formation, were observed in the brain and meninges of both mice by optical microscopy. CONCLUSIONS: This is the first description of eggs in the brains of symptomatic mice that were experimentally infected with S. mansoni. An investigation of experimental neuroschistosomiasis is now feasible.

Brain schistosomiasis in mice experimentally infected with Schistosoma mansoni

Introduction Human neuroschistosomiasis has been reported in the literature, but the possibility of modeling neuroschistosomiasis in mice is controversial. Methods In two research laboratories in Brazil that maintain the Schistosoma mansoni life cycle in rodents, two mice developed signs of brain disease (hemiplegia and spinning), and both were autopsied. Results S. mansoni eggs, both with and without granuloma formation, were observed in the brain and meninges of both mice by optical microscopy. Conclusions This is the first description of eggs in the brains of symptomatic mice that were experimentally infected with S. mansoni. An investigation of experimental neuroschistosomiasis is now feasible. .

Eletro stretching na reabilitação de um hemofílico submetido à radiosinoviortese / Eletro stretching on the rehabilitation of hemophilia a radiation synovectomy submitted

Introdução: A hemofilia A é uma doença que acomete o sistema de coagulação sanguínea. Trata-se de uma coagulopatia recessiva ligada ao cromossomo X causada pela deficiência ou disfunção da glicoproteína plasmática denominada de Fator VIII. Uma complicação freqüente nas hemartroses é a sinovite crônica. O eletrostretching é associação da eletroestimulação estática com fins de alngamento. Objetivo: Esse estudo de caso objetivou-se estudar os efeitos do electrostretching no ganho de Amplitude de movimento (ADM) do joelho de um portador de hemofilia A submetido a radiosinoviortese. Resultados e discussão: Houve um ganho de 81,8% na ADM do joelho acometido do paciente descrito. Conclusão: Conclui-se que o electrostretching após a radiosinoviortese mostrou-se eficaz para a recuperação funcional parcial do paciente descrito.

Introduction: Hemophilia A is a disease that affects the blood clotting system. This is a coagulopathy X-linked recessive disorder caused by deficiency or plasma glycoprotein called Factor VIII. A frequent complication in hermathrosis is the the chronic synovitis. The electrostretching is the association of electrical static stretching. Objective: This case study aimed to study the effect of electro stretching gain in knee range of motion of a patient with hemophilia A radiation synovectomy sibmitted. Results and discussion: There was a gain of 81,8% of amplitude of movement (ADM) of the right knee of the patient described. Conclusions: It's included that electro stretching after radiation synovectomy proved effective for functional recovery of the patient described.

Procedimentos fisioterapêuticos nas cervicalgias ocasionadas por lesões por esforços repetitivos / doenças osteomusculares relacionadas ao trabalho: revisão da literatura / Physical therapysts procedures on neck pain caused by repetitive lesion injury / work related musculoskeletal disease: literature review

Com relativa freqüência, o afastamento do funcionário de seus postos de trabalho ocasionadas por doenças ocupacionais, torna-se cada vez mais presente na vida moderna. As cervicalgias apresentam-se como sendo o segmento corporal mais acometido nas atividades laborais, sendo responsável pelo maior número de dor prévia e consequente afastamento dos postos de trabalho. O objetivo foi revisar a literatura sobre os recursos terapêuticos utilizados no tratamento das algias cervicais, causadas pelo trabalho. Trata-se de um estudo exploratório de revisão sistemática da literatura, buscando artigos publicados em revistas periódicas sobre fisioterapia, bibliografia com publicações em fisioterapia do trabalho, ergonomia e cinesioterapia laboral. O critério de inclusão dos estudos foi a abordagem dos temas relacionados às LER/IDORT que ocasionam disfunções cervicais. A busca eletrônica foi nas bases de dados do Google, Biblioteca Virtual em Saúde, site oficial do Ministério da Saúde - Departamento de Ações Programáticas Estratégicas na Área Técnica de Saúde do Trabalhador, site do Ministério do Trabalho e Emprego. Como resultado verificamos que os procedimentos fisioterapêuticos como: eletroterapia, termoterapia por adição e subtração, LASER, massoterapia, terapias manuais, reeducações posturais, acupuntura, hidroterapia, alongamentos e auto-alongamentos, oferecem comprovadamente, melhora do quadro doloroso, e consequente reabilitação do paciente, comprovando eficiência no tratamento de cervicalgias realcionadas ao trabalho.

With relative frequency, the removal of functionarys from their jobs, caused by occupational diseases, it is increasingly present in modern life. The neck pain is present as the body segment involved in more industrial activities, being responsible for more pain and consequent removal of previous jobs. The objective was to review the literature on the therapeutic resources used in the treatment of cervical pain, caused by work. This is an exploratory study of systematic review of the literature , seeking articles published in journals on regular physical therapy, bibliography with publications in the physical therapy, ergonomics and kinesiotherapy work. The criterion for inclusion of studies was to address the issues related to the Repetitive Lesion Injury / Work Related Musculoskeletal Disease (RLI/WRMD) that cause cervical disorders. The electronic search was performed in the databases of Google, Virtual Health Library, official website of the Ministry of Health - Department of Programmatic Actions Strategic Area of Technology and Occupational Health, site of the Ministrey of Labor and Employment. The results found that the physical therapysts procedures such as electrotherapy, thermothertapy by addition and subtraction, LASER, handly therapy, manual therapy, postural reeducation, acupuncture, hydrotherapy, self-stretching and stretching, offer proven, advance on the painful, and subsequent rehabilitation of the patient, showing efficiency in the treatment of neck pain related to work.

[Renal morphophysiological changes in Wistar rats with malnutrition intra uterine]. / Alterações morfofisiológicas renais em ratos wistar submetidos à má-nutrição intrauterina.

BACKGROUND: Many epidemiological studies suggest that the intra uterine environment is extremely important in determining the future of individual health. Changes in maternal nutritional status, reflected in birth weight may program the offspring to the development of diseases in adulthood. Studies with animals exposed to intrauterine malnutrition have suggested a reduction in the number of clusters in addition to increased blood pressure. OBJECTIVE: To review the literature morphophysiology changes in the kidney of adult Wistar rats exposed to malnutrition during intrauterine life. METHODS: We performed a search in the following databases: PubMed, MEDLINE, SCIENCE DIRECT, LILACS. The main search terms were malnutrition and renal function in Portuguese and English. We included original articles involving albino rats. We excluded review articles as well as those involving humans. RESULTS: According to Franco et al (2009) renal function and the number of glomeruli reduced by poor on intrauterine development, predisposing offspring to kidney disease in adulthood. According to Chen (2009) ultra-glomerular structure is not affected by maternal malnutrition suggesting that this factor does not contribute to the pathogenesis of hypertension after maternal malnutrition. Viana-son et al (2009) believes that stress on placents, causes disruption on sodium pumps in the proximal tubules of the kidney, resulting hypertension. CONCLUSION: The intrauterine malnutrition appears to interfere with the programming of kidney function with changes in glomerular morphophysiology, however, its mechanisms remain uncertain. We suggest further studies of the type and randomized clinical trials aimed at understanding the factors that trigger this process.