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1.
Food Funct ; 14(15): 6853-6863, 2023 Jul 31.
Artículo en Inglés | MEDLINE | ID: mdl-37417892

RESUMEN

This study investigated the effects of virgin coconut oil (VCO) on body weight, white fat depots, and biochemical and morphological parameters in male Swiss mice fed standard (SD) or high-fat (HFD) diets. Thirty-three adult animals were assigned to one of four groups, as follows: SD, SD plus VCO (SDCO), HFD, and HFD plus VCO (HFDCO). VCO had no effects on the Lee index, subcutaneous fat, periepididymal fat, retroperitoneal fat, area under the curve for glucose, or pancreas weight, all of which were increased by HFD. Low-density lipoprotein cholesterol increased in the SDCO group compared with the SD group and decreased in the HFDCO group compared with the HFD group. VCO increased total cholesterol only in the SDCO group compared with the SD group, with no differences between the HFD and HFDCO groups. In conclusion, low-dose VCO supplementation did not improve obesity, had no effects on hepatic or renal function, and had beneficial effects on the lipid profile only in animals fed HFD.


Asunto(s)
Dieta Alta en Grasa , Obesidad , Ratones , Masculino , Animales , Aceite de Coco , Dieta Alta en Grasa/efectos adversos , Obesidad/tratamiento farmacológico , Hígado , Colesterol/farmacología , Tejido Adiposo Blanco , Peso Corporal
2.
J Ethnopharmacol ; 186: 270-279, 2016 Jun 20.
Artículo en Inglés | MEDLINE | ID: mdl-27067367

RESUMEN

ETHNOPHARMACOLOGICAL RELEVANCE: Casearia sylvestris (Salicaceae) is found in South America and presents antiulcerogenic, cytotoxic, antimicrobial, anti-inflammatory and antihypertensive activities. AIM OF THE STUDY: To assess the in vivo and ex vivo antitumor action of a fraction with casearins (FC) and its main component - Casearin X-isolated from C. sylvestris leaves. MATERIALS AND METHODS: Firstly, Sarcoma 180 bearing Swiss mice were treated with FC and Cas X for 7 days. Secondly, BALB/c nude animals received hollow fibers with colon carcinoma (HCT-116) or glioblastoma (SF-295) cells and were treated with FC for 4 days. On 5th day, proliferation was determined by MTT assay. RESULTS: FC 10 and 25mg/kg/day i.p. and 50mg/kg/day oral and Cas X 25mg/kg/day i.p. and 50mg/kg/day oral revealed tumor growth inhibition rates of 35.8, 86.2, 53.7, 90.0 and 65.5% and such tumors demonstrated rare mitoses and coagulation necrosis areas. Similarly, FC reduced multiplying of HCT-116 and SF-295 cells when evaluated by the Hollow Fiber Assay (2.5 and 5mg/kg/day i.p. and 25 and 50mg/kg/day oral), with cell growth inhibition rates ranging from 33.3 to 67.4% (p<0.05). Flow cytometry experiments revealed that FC reduced membrane integrity and induced DNA fragmentation and mitochondrial depolarization (p<0.05). CONCLUSIONS: FC and Cas X were efficient antitumor substances against murine and human cancer cells and caused reversible morphological changes in liver, kidneys and spleens, emphasizing clerodane diterpenes as an emerging class of anticancer molecules.


Asunto(s)
Antineoplásicos Fitogénicos/uso terapéutico , Casearia , Diterpenos de Tipo Clerodano/uso terapéutico , Neoplasias/tratamiento farmacológico , Extractos Vegetales/uso terapéutico , Animales , Antineoplásicos Fitogénicos/farmacología , Línea Celular Tumoral , Proliferación Celular/efectos de los fármacos , Diterpenos de Tipo Clerodano/farmacología , Femenino , Humanos , Riñón/efectos de los fármacos , Riñón/patología , Recuento de Leucocitos , Hígado/efectos de los fármacos , Hígado/patología , Ratones Endogámicos BALB C , Ratones Desnudos , Microscopía , Neoplasias/patología , Extractos Vegetales/farmacología , Hojas de la Planta , Carga Tumoral/efectos de los fármacos
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