[Diagnosis of combined ophthalmic and dermatological manifestations of HIV]. / Diagnostika sochetannykh oftal'mologicheskikh i dermatologicheskikh proyavlenii VICh-infektsii.

This article contains up-to-date information on the features of ophthalmological and dermatological manifestations of human immunodeficiency virus (HIV) infection based on the analysis of studies published in 2018-2022. The article also presents a description of a clinical case of HIV infection in a 54-year-old female patient with synchronous manifestation of eye symptoms in the form of retinal vasculitis of the optic nerve head and Kaposi's sarcoma localized on the skin of the face.

[Hyper-IGE reactions in uveitis and their immunomodulation with cytokine-containing agents].

Examination of 73 patients with primary, active uveitis of various etiology established a high frequency (78%) of IgE hyperconcentrations particularly among patients with viral uveitis (95%) and in the presence of systemic diseases (65.2%). The correlations between IgE and some values of T, humoral immunity, and cytokines support the multiple factors of the immunopathogenesis of uveitis. Combined treatment with local instillations of autocytokines and superlymph provided a high immunomodulating effect. The established IgE hyperproduction in uveitis may be a reflection of either rapidly progressive allergy or an allergic background and serve as a pathogenetic rationale for the use of antihistamines and immunotherapy with cytokine-containing agents.

[Efficiency of treatment of uveitis with the drug superlymph].

Comparative analysis of the results of combination treatment using superlymph and the conventional therapy in 17 and 52 patients, respectively, demonstrated that the combination therapy showed a marked clinical and immunological effect. The use of superlymph in local therapy, unlike the conventional etiopathogenetic treatment, resulted in an earlier decrease and arrest of an inflammatory reaction, in recovery of visual functions (for 2-4 day). Superlymph was found to be well tolerated and to cause no subjective discomfort or complications. Its immunomodulating effect was to normalize the count of T-theophylline-sensitive lymphocytes and, accordingly, the immunoregulation index, the serum concentrations of serum IgG, IgA, particularly IgE, and the phagocytic function of neutrophils. Superlymph exerted a pronounced effect on the systemic and local cytokine status, by decreasing the hypersecretion of cytokines, the regulators of inflammation. The clinical and immunological effects and good tolerability of superlymph permit it to recommend for its wide use in therapy of inflammatory eye diseases.