RESUMEN
Cellulose microspheres have a wide range of applications due to their unique properties and versatility. Various preparation methods have been explored to tailor these microspheres for specific applications. Among these methods, the acetate method using cellulose acetate is well known. However, replacement of the acetate group through the butyrate group significantly extends the variety of morphological properties. In the present work, microspheres based on cellulose acetate butyrate are being developed with modified characteristics in terms of particle size, porosity, surface morphology and the inner structure of the microspheres. While the inner structure of cellulose acetate microspheres is predominantly porous, microspheres prepared from cellulose acetate butyrate are mainly filled or contain several smaller microspheres. Carbon materials from cellulose acetate butyrate microspheres exhibit a high specific surface area of 567 m2 g-1, even without further activation. Activation processes can further increase the specific surface area, accompanied by an adaptation of the pore structure. The prepared carbons show promising results in symmetrical supercapacitors with aqueous 6 M KOH electrolytes. Activated carbons derived from cellulose acetate butyrate microspheres demonstrate an energy density of 12 Wh kg-1 at a power density of 0.9 kW kg-1.
RESUMEN
Cellulose microspheres (CMS) are a type of spherical regenerated cellulose particles with versatile properties which have been used as carrier materials in medical and technical applications. The integration of CMS into paper products opens up novel application scenarios for paper products in a wide range of fields. However, the incorporation of CMS carriers into paper products is challenging and hitherto no reports do exist in literature. Here, we present a feasibility study to incorporate up to 50 w.% CMS in paper hand sheets using retention aids. Our primary observations highlight the successful formation of uniform paper hand sheets retaining its tensile strengths at elevated CMS concentrations. Sheets with high CMS contents exhibit an increase in density and display enhanced surface smoothness - an outcome of a CMS layer forming atop the fiber base - which effectively bridges voids and rectifies surface irregularities as supported by Gurley testing, infinite focus microscopy and scanning electron microscopy. While our primary objective centered on the general feasibility to manufacture CMS-containing papers, the resulting composite scaffold carries significant potential as a platform for innovative, functional paper-based materials.
RESUMEN
Cellulose ferulate, synthesized by Mitsunobu reaction, is shaped into thin films and also used as an aqueous dispersion to perform artificial lignin polymerization on anchor groups. This biomimetic approach is carried out in a Quartz crystal microbalance with a dissipation monitoring (QCM-D) device to enable online monitoring of the dehydrogenation, applying H2O2 and adsorbed horseradish peroxidase (HRP). The systematic use of phenylpropanoids with different oxidation states, i.e., ferulic acid, coniferyl aldehyde, coniferyl alcohol, and eugenol allowed to conclude structure-property relationships. Both the deposited material, as well as the surface roughness increased with the hydrophobicity of the monomers. Beyond surface characterizations, py-GC-MS, HSQC NMR spectroscopy and Size exclusion chromatography (SEC) measurements revealed the linkage types ß-ß, ß-5, 5-5, and ß-O-4, as well as the oligomeric character of the dehydrogenation products. All samples possessed an antibacterial activity against B. subtilis and can be used in the field of antimicrobial biomaterials.
Asunto(s)
Celulosa , Lignina , Lignina/química , Celulosa/química , Peróxido de Hidrógeno/química , Hidrogenación , Ácidos Cumáricos/química , Peroxidasa de Rábano Silvestre/química , Peroxidasa de Rábano Silvestre/metabolismo , Biomimética/métodos , Materiales Biomiméticos/química , Materiales Biomiméticos/farmacología , Tecnicas de Microbalanza del Cristal de Cuarzo , Antibacterianos/farmacología , Antibacterianos/química , Propiedades de Superficie , FenolesRESUMEN
Biomass-based materials have emerged as a promising alternative to the conventional graphite anode in Li-ion batteries due to their renewability, low cost, and environmental friendliness. Therefore, a facile synthesis method for porous hard carbons based on cellulose acetate microspheres and bead cellulose is used, and their application as anode materials in Li-ion batteries is discussed. The resulting porous carbons exhibit promising electrochemical characteristics, including a reversible capacity of about 300â mAh g-1 at 0.1â C (37â mA g-1) after 50 cycles, and stable capacities up to 210â mAh g-1 over 1000 cycles at 1â C (372â mA g-1) in half-cells for cellulose acetate microspheres carbonised at 1200 °C. Moreover, at 60 °C cellulose-derived carbons show higher specific capacities than graphite (300â mAh g-1 vs 240â mAh g-1 at 1â C after 500 cycles), indicating their potential for use in high-temperature applications. The different charge storage mechanisms of the prepared hard carbon materials and graphite are observed. While capacity of graphite is mainly controlled by the Faradaic redox process, the cellulose-derived carbons combine Faradaic intercalation and capacitive charge adsorption.
RESUMEN
BACKGROUND: Transglutaminase 2 (TGase 2) is a multifunctional protein and has a prominent role in various (patho)physiological processes. In particular, its transamidase activity, which is rather latent under physiological conditions, gains importance in malignant cells. Thus, there is a great need of theranostic probes for targeting tumor-associated TGase 2, and targeted covalent inhibitors appear to be particularly attractive as vector molecules. Such an inhibitor, equipped with a radionuclide suitable for noninvasive imaging, would be supportive for answering the general question on the possibility for functional characterization of tumor-associated TGase 2. For this purpose, the recently developed 18F-labeled Nε-acryloyllysine piperazide [18F]7b, which is a potent and selective irreversible inhibitor of TGase 2, was subject to a detailed radiopharmacological characterization herein. RESULTS: An alternative radiosynthesis of [18F]7b is presented, which demands less than 300 µg of the respective trimethylammonio precursor per synthesis and provides [18F]7b in good radiochemical yields (17 ± 7%) and high (radio)chemical purities (≥ 99%). Ex vivo biodistribution studies in healthy mice at 5 and 60 min p.i. revealed no permanent enrichment of 18F-activity in tissues with the exception of the bone tissue. In vivo pretreatment with ketoconazole and in vitro murine liver microsome studies complemented by mass spectrometric analysis demonstrated that bone uptake originates from metabolically released [18F]fluoride. Further metabolic transformations of [18F]7b include mono-hydroxylation and glucuronidation. Based on blood sampling data and liver microsome experiments, pharmacokinetic parameters such as plasma and intrinsic clearance were derived, which substantiated the apparently rapid distribution of [18F]7b in and elimination from the organisms. A TGase 2-mediated uptake of [18F]7b in different tumor cell lines could not be proven. Moreover, evaluation of [18F]7b in melanoma tumor xenograft models based on A375-hS100A4 (TGase 2 +) and MeWo (TGase 2 -) cells by ex vivo biodistribution and PET imaging studies were not indicative for a specific targeting. CONCLUSION: [18F]7b is a valuable radiometric tool to study TGase 2 in vitro under various conditions. However, its suitability for targeting tumor-associated TGase 2 is strongly limited due its unfavorable pharmacokinetic properties as demonstrated in rodents. Consequently, from a radiochemical perspective [18F]7b requires appropriate structural modifications to overcome these limitations.
RESUMEN
In recent years, the potential of lignins as a resource for material-based applications has been highlighted in many scientific and nonscientific publications. But still, to date, a lack of detailed structural knowledge about this ultracomplex biopolymer undermines its great potential. The chemical complexity of lignin demands a combination of different, powerful analytical methods, in order to obtain these necessary information. In this paper, we demonstrate a multispectroscopic approach using liquid-state and solid-state Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR-MS) and nuclear magnetic resonance (NMR) spectroscopy to characterize a fractionated LignoBoost lignin. Individual FT-ICR-MS, tandem MS, and NMR results helped to determine relevant information about the different lignin fractions, such as molecular weight distributions, oligomer sizes, linkage types, and presence of specific functional groups. In addition, a hetero spectroscopic correlation approach was applied to chemometrically combine MS, MS/MS, and NMR data sets. From these correlation analyses, it became obvious that a combination of tandem MS and NMR data sets gives the opportunity to comprehensively study and describe the general structure of complex biopolymer samples. Compound-specific structural information are obtainable, if this correlation approach is extended to 1D-MS and NMR data, as specific functional groups or linkages are verifiable for a defined molecular formula. This enables structural characterization of individual lignin compounds without the necessity for tandem MS experiments. Hence, these correlation results significantly improve the depth of information of each individual analysis and will hopefully help to structurally elucidate entire lignin structures in the near future.