Cochleotoxicity and acute kidney injury secondary to parenteral gentamicin administration in a dog.

A 5-year-old neutered male Labrador retriever dog was presented on referral for anuric acute kidney injury (AKI) presumed secondary to parenteral gentamicin administration. Initial management of AKI included a high dose of furosemide for 16 hours which may have contributed to the renal and cochlear damage. The dog received a total of 8 intermittent hemodialysis sessions during hospitalization. While in hospital, the dog became deaf, and brainstem auditory evoked response testing revealed absence of waveforms in both ears, consistent with bilateral deafness due to severe cochleotoxicity. After 33 days of hospitalization, the dog was discharged with persistent deafness, confirmed by a second brainstem auditory evoked response.

Cochléotoxicité et dommage rénal aigu secondaires à l'administration parentérale de gentamicine à un chien. Un chien mâle castré de race Labrador âgé de 5 ans a été présenté en référence pour dommage rénal aigu anurique (AKI) présumé secondaire à l'administration parentérale de gentamicine. La gestion initiale de l'AKI incluait une dose élevée de furosémide pour 16 heures, ce qui pourrait avoir contribué aux dommages rénaux et cochléaire. Le chien a reçu un total de huit sessions intermittentes d'hémodialyse pendant son hospitalisation. Durant son séjour à l'hôpital, le chien est devenu sourd, et un test pour les potentiels évoqués auditifs du tronc cérébral a révélé l'absence d'ondes dans les deux oreilles, ce qui est cohérent avec une surdité bilatérale due à une cochléotoxicité sévère. Après 33 jours d'hospitalisation, le chien a obtenu son congé malgré une surdité persistante, confirmée par un deuxième test de potentiels évoqués auditifs du tronc cérébral.(Traduit par Dr Serge Messier).

Pneumatosis Coli in a Dog.

The objective of this report is to document a case of pneumatosis coli in an immunosuppressed dog successfully treated with supportive care that included hyperbaric oxygen. A 9 yr old, neutered male Maltese was presented for hematochezia of ∼36 h duration. The dog had a history of immune-mediated thrombocytopenia that was well managed with prednisone and azathioprine. Initial evaluation was unremarkable except for increased rectal temperature and hematochezia on digital rectal examination. Abdominal radiographs revealed diffuse gas within the colonic wall consistent with pneumatosis coli. Scant-free air was also appreciated in the peritoneal and retroperitoneal cavities. The dog was managed for 4 days in hospital with broad spectrum antibiotic, anthelminthic, and gastroprotectant therapy. He received one session of hyperbaric oxygen therapy while in hospital. Repeat abdominal radiographs after 72 hr of medical management showed improvement of the pneumatosis coli. After 4 days of hospitalization, he was discharged with resolution of clinical signs. Pneumatosis coli is rarely diagnosed in dogs but should be considered in cases with clinical signs of colorectal disease.